Vigor Fruit Punch Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Vigor Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vigor Fruit Punch is a dietary supplement by Leviathan Wellness with 6 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate, L-Citrulline, Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vigor Fruit Punch by Leviathan Wellness
Ask about any prescription or over-the-counter medication and we check it for interactions with Vigor Fruit Punch by Leviathan Wellness — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vigor Fruit Punch by Leviathan Wellness
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Vigor Fruit Punch is a powder with 6 ingredients, 4 of which are active. L-citrulline is an amino acid your body converts to another amino acid (L-arginine) to improve blood flow and athletic performance.
Malic acid is an organic acid that may help with dry mouth. Agmatine sulfate is a compound derived from the amino acid arginine, and glycerol (GlycerPump) is a naturally occurring compound that supports hydration and may boost athletic performance.
Two other active ingredients — VasoDrive-AP and Nitrosigine — are also present. The product also contains inactive ingredients like citric acid, flavoring, sweeteners, and silicon dioxide.
Does it work?
Moderate evidence
L-citrulline is possibly effective for athletic performance. It's rated as possibly ineffective for muscle-wasting conditions (sarcopenia), and there isn't enough reliable evidence to rate it for cardiovascular disease, heart failure, blood sugar control, or Reye syndrome.
Malic acid may be helpful for dry mouth, but evidence is insufficient for acne, GERD, fatigue, fibromyalgia, and psoriasis. Glycerol is likely effective for constipation and possibly effective for athletic performance, but likely ineffective for stroke and possibly ineffective for meningitis and prematurity.
For agmatine, the evidence we hold does not establish effectiveness for any condition listed. We have no effectiveness data on file for VasoDrive-AP or Nitrosigine.
How safe is it?
Well-documented data
L-citrulline is generally well tolerated in healthy adults, though long-term safety is not fully studied. The most common side effects are gastrointestinal discomfort and heartburn; a small number of people with pulmonary hypertension reported cough.
Malic acid is well tolerated in food amounts, but supplement-dose safety hasn't been well studied — caution is advised. Agmatine appears well tolerated short-term, but long-term safety in humans is unclear.
A small number of people in trials reported diarrhea, indigestion, or nausea within a few days of starting, which resolved when they stopped. Glycerol is generally well tolerated at normal amounts, though large doses can cause stomach upset, bloating, nausea, vomiting, dizziness, and headache.
There is not enough safety data on L-citrulline, agmatine, or glycerol during pregnancy or breastfeeding — avoid supplemental use in these situations. Malic acid is rated likely safe in pregnancy and lactation.
Meds to double-check
Moderate interaction found
Before you take Vigor Fruit Punch, double-check if you use blood pressure medications (antihypertensive drugs) — L-citrulline, malic acid, and agmatine can all lower blood pressure further. Also check for erectile dysfunction medications (phosphodiesterase-5 inhibitors), which may have additive blood-vessel-relaxing effects with L-citrulline.
If you take diabetes medications, agmatine could increase your low blood sugar risk. We could not check VasoDrive-AP or Nitrosigine for interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Vigor Fruit Punch is designed for athletic performance and circulation, mainly through L-citrulline. It's generally well tolerated, but if you take blood pressure medications, diabetes drugs, or erectile dysfunction medications, run this product and your exact prescriptions through the checker below first — the interactions can be serious.
Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or manage a chronic condition.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vigor Fruit Punch, straight from the product label.
| Brand | Leviathan Wellness |
|---|---|
| Net contents | 409.5 Gram(s); 14.44 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 322131 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vigor Fruit Punch by Leviathan Wellness, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 5000 mg | -- |
| Malic Acid | 2000 mg | -- |
| Agmatine Sulfate | 500 mg | -- |
| VasoDrive-AP | 120 mg | -- |
| GlycerPump | 1500 mg | -- |
| Nitrosigine | 500 mg | -- |
Other ingredients: Silicon Dioxide, Natural & Artificial Flavors, Citric Acid, Sucralose, Acesulfame Potassium
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Suggested use: As a dietary supplement, take one (1) scoop with 8-12 fl oz of water 20-40 mins prior to train sessions.
Precautions
Warning: For use by healthy adults only, not recommended for persons under the age of 18.
Do not use if you are pregnant or nursing.
Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately.
Keep out of the reach of children.
This product is produced in a facility that also processes milk, eggs, fish, shellfish, tree nuts, peanuts, soy, wheat, and may contain trace amounts of all ingredients.
Contains: Milk (VasoDrive-AP (Casein Hydrolysate))
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Storage instructions: Store in a cool dry place.
Brand IP Statement(s)
GlycerPump is a registered trademark of Pinnacle Ingredients Pty Ltd. Nitrosigine and Nitrosigine logo are registered trademarks of Nutrition 21, LLC. Nitrosigine is patent protected. VasoDrive-AP is the registered trademark of Nova Nutra LLC.
Seals/Symbols
GMP Good Manufacturing Practice Made in USA from Global Materials
Formulation
Stimulant free nitric oxide boosting pre-workout Increased muscle fullness Boost nitric oxide Supports blood flow Increase endurance
Stimulant free
Formula
Fruit punch Naturally & artificially flavored
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vigor Fruit Punch by Leviathan Wellness label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vigor Fruit Punch by Leviathan Wellness
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size13.86 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsMalic Acid
Interacts with172 drugs
Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....
Malic Acid monograph & interactionsAgmatine Sulfate
Interacts with258 drugs
Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...
Agmatine Sulfate monograph & interactionsVasoDrive-AP
GlycerPump
No knowninteractions
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...
GlycerPump monograph & interactionsNitrosigine
Other (inactive) ingredients: Silicon Dioxide, Natural & Artificial Flavors, Citric Acid, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.
Vigor Fruit Punch by Leviathan Wellness Drug Interactions
HelloPharmacist Interaction Report
Vigor Fruit Punch by Leviathan Wellness contains several ingredients that interact with common medications, and you'll want to check your specific drugs before starting.
Read the full breakdown — every affected drug type, severity by severity
L-citrulline is the main concern. It can lower blood pressure (hypotension) when combined with blood pressure medications (antihypertensive drugs), and it may amplify the effects of erectile dysfunction drugs (phosphodiesterase-5 inhibitors like sildenafil) in ways that increase dizziness or dangerously low blood pressure.
Both are Moderate-severity interactions.
Two other active ingredients also interact with blood pressure drugs. Malic acid and agmatine sulfate can each theoretically add to the blood-pressure-lowering effect of antihypertensive medications, raising the risk of low blood pressure.
Agmatine has an additional Moderate interaction: it may increase the risk of low blood sugar (hypoglycemia) when taken with diabetes medications.
We could not check VasoDrive-AP or Nitrosigine — we hold no interaction data for these ingredients. Glycerol, which we did check, shows no interactions in our data, but that isn't a guarantee none exist.
Altogether, these interactions span 261 individual medications. Use the medication checker on this page to verify your specific prescriptions before you add this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vigor Fruit Punch?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vigor Fruit Punch interact with 264 drugs. Click any drug to see the details.
3 of the 6 ingredients in Vigor Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate L-Citrulline Malic Acid
Bendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Nadolol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bendroflumethiazide, Nadolol interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bendroflumethiazide, Rauwolfia Serpentina interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Rauwolfia Serpentina interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benzthiazide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Benzthiazide interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Betaxolol interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Betaxolol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bisoprolol interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Malic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bisoprolol, Hydrochlorothiazide interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bisoprolol, Hydrochlorothiazide interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bosentan interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bosentan interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bumetanide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bumetanide interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Malic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bumetanide (iv) interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bumetanide (iv) interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bumetanide (oral) interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Bumetanide (oral) interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Bumetanide (oral) interactionCanagliflozinInvokana
How Canagliflozin interacts with Vigor Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Agmatine SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Agmatine Sulfate + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Vigor Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Agmatine SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Agmatine Sulfate + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Vigor Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Agmatine SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Agmatine Sulfate + Canagliflozin, Metformin Hydrochloride interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Candesartan Cilexetil interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Candesartan Cilexetil interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Candesartan Cilexetil, Hydrochlorothiazide interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Candesartan Cilexetil, Hydrochlorothiazide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Captopril interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Captopril interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Captopril, Hydrochlorothiazide interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Captopril, Hydrochlorothiazide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Carteolol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Carteolol interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Carvedilol interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Carvedilol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Celiprolol interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Celiprolol interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Chlorothiazide interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Chlorothiazide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Chlorothiazide, Methyldopa interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Chlorothiazide, Methyldopa interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Chlorothiazide, Reserpine interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Chlorothiazide, Reserpine interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Chlorothiazide, Reserpine interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Vigor Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Agmatine SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Agmatine Sulfate + Chlorpropamide interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Chlorthalidone interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Chlorthalidone interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Chlorthalidone, Clonidine interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Chlorthalidone, Clonidine interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Cilazapril interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Cilazapril interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Cilazapril interactionClevidipineCleviprex
How Clevidipine interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Clevidipine interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Clevidipine interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Clevidipine interactionClonidineCatapres
How Clonidine interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Agmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Clonidine interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Clonidine interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Vigor Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Cryptenamine, Methyclothiazide interactionMalic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Cryptenamine, Methyclothiazide interactionAgmatine SulfateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine Sulfate + Cryptenamine, Methyclothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vigor Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Agmatine Sulfate
Antidiabetes Drugs
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.
Antihypertensive Drugs
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Malic Acid
Antihypertensive Drugs
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.
Brand information
Manufacturer and brand details for Vigor Fruit Punch, from the product label.
Leviathan Wellness
See all Leviathan Wellness products- Name
- Leviathan Wellness
- Street Address
- 1504 Union Ave
- City
- Natrona Heights
- State
- PA
- ZipCode
- 15065
- Phone Number
- 724-236-5015
- Web Address
- leviathansupps.com
Vigor Fruit Punch by Leviathan Wellness: Common Questions
Does Vigor Fruit Punch by Leviathan Wellness interact with any medications?
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What are the most common side effects?
Does this actually improve athletic performance?
Can I take this if I have high blood pressure?
What is L-citrulline and why is it in here?
Is this a complete pre-workout, or do I need other supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vigor Fruit Punch’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographMalic Acid
Interacts with 172 drugsMalic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...
Read the full Malic Acid monograph → Herb & supplement monographAgmatine
Interacts with 258 drugsAgmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...
Read the full Agmatine monograph → Herb & supplement monographGlycerol
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...
Read the full Glycerol monograph →Sources & How We Checked
Vigor Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Malic Acid 7 references
- Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
- Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
- Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
- Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
- CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
- Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.
Agmatine 3 references
- Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
- Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
- Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed
Glycerol 8 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
- Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
- Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
- Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
- Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
- Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
- Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC