Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Vigor Fruit Punch Ingredients & Drug Interactions

by Leviathan Wellness

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Vigor Fruit Punch is a dietary supplement by Leviathan Wellness with 6 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate, L-Citrulline, Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vigor Fruit Punch by Leviathan Wellness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Vigor Fruit Punch is a powder with 6 ingredients, 4 of which are active. L-citrulline is an amino acid your body converts to another amino acid (L-arginine) to improve blood flow and athletic performance.

Malic acid is an organic acid that may help with dry mouth. Agmatine sulfate is a compound derived from the amino acid arginine, and glycerol (GlycerPump) is a naturally occurring compound that supports hydration and may boost athletic performance.

Two other active ingredients — VasoDrive-AP and Nitrosigine — are also present. The product also contains inactive ingredients like citric acid, flavoring, sweeteners, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Athletic performance and exercise support.
  • We looked for evidence on: Athletic performance, Fatigue, Muscle strength, Muscle endurance, Exercise recovery, Muscular power.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.
  • Also on file: L-citrulline is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

L-citrulline is possibly effective for athletic performance. It's rated as possibly ineffective for muscle-wasting conditions (sarcopenia), and there isn't enough reliable evidence to rate it for cardiovascular disease, heart failure, blood sugar control, or Reye syndrome.

Malic acid may be helpful for dry mouth, but evidence is insufficient for acne, GERD, fatigue, fibromyalgia, and psoriasis. Glycerol is likely effective for constipation and possibly effective for athletic performance, but likely ineffective for stroke and possibly ineffective for meningitis and prematurity.

For agmatine, the evidence we hold does not establish effectiveness for any condition listed. We have no effectiveness data on file for VasoDrive-AP or Nitrosigine.

The evidence, ingredient by ingredient L-citrulline Malic Acid Agmatine Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety is not fully studied. The most common side effects are gastrointestinal discomfort and heartburn; a small number of people with pulmonary hypertension reported cough.

Malic acid is well tolerated in food amounts, but supplement-dose safety hasn't been well studied — caution is advised. Agmatine appears well tolerated short-term, but long-term safety in humans is unclear.

A small number of people in trials reported diarrhea, indigestion, or nausea within a few days of starting, which resolved when they stopped. Glycerol is generally well tolerated at normal amounts, though large doses can cause stomach upset, bloating, nausea, vomiting, dizziness, and headache.

There is not enough safety data on L-citrulline, agmatine, or glycerol during pregnancy or breastfeeding — avoid supplemental use in these situations. Malic acid is rated likely safe in pregnancy and lactation.

Side effects, ingredient by ingredient L-citrulline Malic Acid Agmatine Glycerol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — L-citrulline, Malic Acid, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Vigor Fruit Punch, double-check if you use blood pressure medications (antihypertensive drugs) — L-citrulline, malic acid, and agmatine can all lower blood pressure further. Also check for erectile dysfunction medications (phosphodiesterase-5 inhibitors), which may have additive blood-vessel-relaxing effects with L-citrulline.

If you take diabetes medications, agmatine could increase your low blood sugar risk. We could not check VasoDrive-AP or Nitrosigine for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vigor Fruit Punch is designed for athletic performance and circulation, mainly through L-citrulline. It's generally well tolerated, but if you take blood pressure medications, diabetes drugs, or erectile dysfunction medications, run this product and your exact prescriptions through the checker below first — the interactions can be serious.

Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or manage a chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vigor Fruit Punch, straight from the product label.

Brand Leviathan Wellness
Net contents 409.5 Gram(s); 14.44 Ounce(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 322131
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vigor Fruit Punch by Leviathan Wellness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13.86 Gram(s)
Maximum serving Sizes:
13.86 Gram(s)
Servings per container
30
IngredientAmount% DV
L-Citrulline5000 mg--
Malic Acid2000 mg--
Agmatine Sulfate500 mg--
VasoDrive-AP120 mg--
GlycerPump1500 mg--
Nitrosigine500 mg--

Other ingredients: Silicon Dioxide, Natural & Artificial Flavors, Citric Acid, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Suggested use: As a dietary supplement, take one (1) scoop with 8-12 fl oz of water 20-40 mins prior to train sessions.

Precautions

Warning: For use by healthy adults only, not recommended for persons under the age of 18.

Do not use if you are pregnant or nursing.

Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately.

Keep out of the reach of children.

This product is produced in a facility that also processes milk, eggs, fish, shellfish, tree nuts, peanuts, soy, wheat, and may contain trace amounts of all ingredients.

Contains: Milk (VasoDrive-AP (Casein Hydrolysate))

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage instructions: Store in a cool dry place.

Brand IP Statement(s)

GlycerPump is a registered trademark of Pinnacle Ingredients Pty Ltd. Nitrosigine and Nitrosigine logo are registered trademarks of Nutrition 21, LLC. Nitrosigine is patent protected. VasoDrive-AP is the registered trademark of Nova Nutra LLC.

Seals/Symbols

GMP Good Manufacturing Practice Made in USA from Global Materials

Formulation

Stimulant free nitric oxide boosting pre-workout Increased muscle fullness Boost nitric oxide Supports blood flow Increase endurance

Stimulant free

Formula

Fruit punch Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

See for yourself

Vigor Fruit Punch by Leviathan Wellness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vigor Fruit Punch by Leviathan Wellness

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size13.86 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
5000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Malic Acid

Interacts with
172 drugs
2000 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

Malic Acid monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

VasoDrive-AP

120 mg per serving Form: Casein Hydrolysate

GlycerPump

No known
interactions
1500 mg per serving Form: Glycerol, Powder

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

GlycerPump monograph & interactions

Nitrosigine

500 mg per serving Form: Inositol Arginine Silicate

Other (inactive) ingredients: Silicon Dioxide, Natural & Artificial Flavors, Citric Acid, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vigor Fruit Punch by Leviathan Wellness Drug Interactions

Want to check YOUR meds against Vigor Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Vigor Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D

Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Vigor Fruit Punch, from the product label.

Leviathan Wellness

See all Leviathan Wellness products
Name
Leviathan Wellness
Street Address
1504 Union Ave
City
Natrona Heights
State
PA
ZipCode
15065
Phone Number
724-236-5015
Web Address
leviathansupps.com
Pharmacist Counseling Corner

Vigor Fruit Punch by Leviathan Wellness: Common Questions

Does Vigor Fruit Punch by Leviathan Wellness interact with any medications?
Yes. Based on its ingredients, Vigor Fruit Punch has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vigor Fruit Punch contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while I'm pregnant or breastfeeding?
L-citrulline, agmatine, and glycerol don't have enough safety data, so the guidance is to avoid them during pregnancy and while breastfeeding. Malic acid is rated likely safe in both. Talk with your doctor or pharmacist about your individual situation before starting.
What are the most common side effects?
L-citrulline most commonly causes gastrointestinal discomfort and heartburn. Agmatine may cause diarrhea, indigestion, or nausea, usually within a few days of starting. Glycerol can cause bloating, nausea, diarrhea, and dizziness at larger doses. Most people tolerate these ingredients well, but stomach upset is the most frequent complaint.
Does this actually improve athletic performance?
L-citrulline is possibly effective for athletic performance, meaning some evidence supports it, but it's not guaranteed. Glycerol is also possibly effective for athletic performance. The other ingredients — malic acid and agmatine — don't have established evidence for athletic performance in our data.
Can I take this if I have high blood pressure?
No — you need to check with your pharmacist or doctor first. L-citrulline, malic acid, and agmatine can all theoretically lower blood pressure further, which could be risky if you're already on blood pressure medication. Don't start this without clearance from your healthcare provider.
What is L-citrulline and why is it in here?
L-citrulline is an amino acid your body converts to L-arginine, which helps improve blood flow and relax blood vessels. It's in this product mainly because it's possibly effective for athletic performance and may support circulation.
Is this a complete pre-workout, or do I need other supplements?
Vigor Fruit Punch contains ingredients for blood flow and hydration support, but we have no data on whether it's formulated as a complete pre-workout or how it compares to other products. That's a question for the manufacturer or your trainer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vigor Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vigor Fruit Punch label
Sources

Sources & How We Checked

Vigor Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Malic Acid 7 references
  1. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  2. Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
  3. Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
  4. Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
  5. Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
  6. CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
  7. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.

See these in context on the Malic Acid monograph →

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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