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Dietary supplement

Vitamin B2 Ingredients & Drug Interactions

by BioCare

Vitamin B2 label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin B2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitamin B2 is a dietary supplement by BioCare with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin B2 by BioCare

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B2 by BioCare — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin B2 by BioCare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Vitamin B2, also called riboflavin. B2 is a B vitamin your body uses for energy and cell health.

The inactive ingredients are cellulose, hydroxypropyl methylcellulose, and magnesium stearate — standard capsule fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy metabolism and nervous system function.
  • We looked for evidence on: fatigue, tiredness, nervous system support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold don't include effectiveness ratings for Vitamin B2, so the evidence isn't established in our data. If you're curious whether it'll help with a specific concern — energy, migraines, or something else — that's a good question for your pharmacist or doctor.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is considered very safe; your body gets rid of excess amounts in your urine. It's generally well tolerated when taken by mouth.

The most common side effects are dose-related nausea and bright yellow urine — harmless, but noticeable. In a clinical study, one person out of 28 reported diarrhea and one reported increased urination after starting a high dose (400 mg daily), so these effects are rare.

Riboflavin is actually needed during pregnancy and breastfeeding and is generally safe at recommended amounts. If you're pregnant or nursing and thinking about a higher-dose supplement, check with your provider first.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take tetracycline antibiotics (such as doxycycline, minocycline, or tetracycline), double-check with your pharmacist before starting this supplement — there's a theoretical concern it may reduce how well they work. For any other medications, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vitamin B2 is a straightforward, well-tolerated B vitamin — a good pick if you're looking for basic nutritional support. The only real caution is if you're on a tetracycline antibiotic; run that combination by us first.

Otherwise, talk to your pharmacist if you have questions about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B2, straight from the product label.

Brand BioCare
Barcode (UPC) 5033290524302
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309765
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B2 by BioCare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
5033290524302
IngredientAmount% DV
Vitamin B250 mg3571%

Other ingredients: Cellulose, Hydroxypropyl Methylcellulose, Vitamin B2, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: 1 capsule taken daily with food, or as professionally directed.

Precautions

This product should not be used as a substitute for a varied diet and healthy lifestyle. Do not exceed the stated recommended daily intake. Do not purchase if the seal is broken. If you are under medical supervision, please consult a doctor before use.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formulation

Vegetarian & vegan

Vitamin B2 contributes to normal energy-yielding metabolism, the reduction of tiredness & fatigue & normal functioning of the nervous system.

Formula

Vitamin B2 as riboflavin for energy & nervous support

FDA Statement of Identity

Food Supplement

General Statements

NRV = Nutrient Reference value

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin B2 by BioCare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin B2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin B2 by BioCare

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Vitamin B2

Interacts with
20 drugs
50 mg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Vitamin B2 monograph & interactions

Other (inactive) ingredients: Cellulose, Hydroxypropyl Methylcellulose, Vitamin B2, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B2 by BioCare Drug Interactions

Want to check YOUR meds against Vitamin B2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Vitamin B2 20

Individual Drug Interactions

The ingredients in Vitamin B2 interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin B2 interact with drugs. Each result below shows which ingredient is responsible. Vitamin B2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B2 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B21 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Vitamin B2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin B2, from the product label.

BioCare

See all BioCare products
Name
UK - BioCare Ltd
Street Address
1 Hedera Road
State
Redditch
ZipCode
B98 9EY
Phone Number
+44 0121 433 3727
Web Address
www.biocare.co.uk
Pharmacist Counseling Corner

Vitamin B2 by BioCare: Common Questions

Does Vitamin B2 by BioCare interact with any medications?
Yes. Based on its ingredients, Vitamin B2 has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B2 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Vitamin B2 turn my urine yellow?
Yes, at higher doses it can cause bright yellow urine. That's harmless — it's just excess riboflavin your body is getting rid of. If you're taking a standard dose, you may still notice some color change.
Is it safe to take during pregnancy?
Yes, riboflavin is needed during pregnancy and is generally safe at recommended doses. If you're thinking about a higher-dose supplement, mention it to your provider first to make sure it's right for you.
Is it safe while breastfeeding?
Yes, riboflavin is needed while breastfeeding and is generally safe at recommended amounts. For higher doses, ask your provider about what's best for your situation.
What side effects should I watch for?
Riboflavin is generally well tolerated. The most common side effects are dose-related nausea and the bright yellow urine we mentioned. Diarrhea and increased urination are rare — they showed up in only one person each in a clinical study of 28 people at high doses.
Can I take this with my tetracycline antibiotic?
Check with us first. Riboflavin may theoretically lower how well tetracycline antibiotics work, though this hasn't been observed in actual patients yet. We can help you figure out the safest approach for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B2 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B2 label
Go deeper

The Full Monographs Behind Vitamin B2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Vitamin B2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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