Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Waist-Line Control Ingredients & Drug Interactions

by Life Extension

Waist-Line Control label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Waist-Line Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Waist-Line Control is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mangosteen fruit rind extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Waist-Line Control by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Waist-Line Control by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Waist-Line Control by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Meratrim Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

Waist-Line Control has two active ingredients: Meratrim Proprietary Blend and mangosteen fruit rind extract. The product also contains inactive ingredients (microcrystalline cellulose, cellulose, rice bran extract, stearate, and silica) that serve as fillers and binders.

Meratrim is a branded plant-derived blend, but we don't have its specific components listed on this page. Mangosteen is an extract from the fruit rind of the mangosteen plant, traditionally used in Asian medicine.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Mangosteen's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Waist line and weight control support.
  • We looked for evidence on: Obesity, Weight management, Body composition, Metabolic health.
  • The closest evidence on file: Mangosteen is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence for mangosteen is mixed. It's possibly effective for periodontitis (gum disease), but for androgenic alopecia (male pattern baldness) and Alzheimer's disease, the evidence isn't established well enough to rate it.

We don't hold effectiveness data for the Meratrim blend or for Indian Sphaeranthus, so we can't speak to how well those ingredients work for weight management or any other purpose.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen extract is generally well tolerated as a food, though long-term safety of concentrated supplement forms hasn't been well studied. At doses up to 560 mg daily, some people reported mild tiredness, headache, dizziness, and malaise, as well as digestive effects like constipation, nausea, bloating, or diarrhea — though it's unclear whether mangosteen caused these.

The safety data advises against using mangosteen supplements during pregnancy or breastfeeding. We don't have safety information on file for the other ingredients in this product.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Waist-Line Control, double-check blood thinners and antiplatelet drugs — aspirin, warfarin, clopidogrel, and similar medications — with your pharmacist, as mangosteen may raise bleeding risk. Also check if you're on donepezil (Aricept) for Alzheimer's disease, as mangosteen might increase its effects.

We couldn't check the Meratrim blend or Indian Sphaeranthus, so mention those to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners or donepezil, check with your pharmacist before starting this product. If you're pregnant, breastfeeding, or have a bleeding disorder, talk to your doctor first.

We couldn't fully assess all ingredients here, so a conversation with your pharmacist about your specific situation is smart.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Waist-Line Control, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870250968
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328797
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Waist-Line Control by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
737870250968
IngredientAmount% DV
Meratrim Proprietary Blend400 mg--
Mangosteen fruit rind extract0 NP--
Indian Sphaeranthus Flower Head Extract0 NP--

Other ingredients: Microcrystalline Cellulose, Cellulose, Rice Bran Extract, Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take once (1) capsule twice daily 30 minutes before meals, or as recommended by a healthcare practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten free Non GMO LE Certified

Targets weight, hips, and waist This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

Storage

Store tightly closed in a cool, dry place.

Brand IP Statement(s)

Meratrim. is a Laila Nutraceuticals trademark, registered in USA.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Waist-Line Control by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Waist-Line Control label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Waist-Line Control by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Meratrim Proprietary Blend

400 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Rice Bran Extract, Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Waist-Line Control by Life Extension Drug Interactions

Want to check YOUR meds against Waist-Line Control?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Mangosteen fruit rind extract 125

Individual Drug Interactions

The ingredients in Waist-Line Control interact with 125 drugs. Click any drug to see the details.

1 of the 2 ingredients in Waist-Line Control interact with drugs. Each result below shows which ingredient is responsible. Mangosteen fruit rind extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Waist-Line Control with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mangosteen fruit rind extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Mangosteen fruit rind extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Waist-Line Control, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Waist-Line Control by Life Extension: Common Questions

Does Waist-Line Control by Life Extension interact with any medications?
Yes. Based on its ingredients, Waist-Line Control has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Waist-Line Control contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against using mangosteen supplements during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about whether this product is right for you in those situations.
What's mangosteen and why is it in here?
Mangosteen is a tropical fruit; we use an extract from its rind. The evidence shows it's possibly effective for gum disease, but for weight management — the purpose of this product — we don't have solid data on how well it works.
What side effects might I get from mangosteen?
Some people reported mild tiredness, headache, dizziness, digestive upset (constipation, nausea, bloating, diarrhea), and cold-like symptoms at typical doses. It's not certain mangosteen caused these, and they appear to be mild.
I take a blood thinner. Is this safe for me?
Mangosteen in this product may raise your bleeding risk if you're on blood thinners like warfarin, aspirin, or clopidogrel. Check with your pharmacist before you start — don't begin it on your own.
What does Meratrim do?
Meratrim is a branded plant blend in this product, but we don't have its specific ingredients listed here. Contact the manufacturer for details on what's in it and what each component is meant to do.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Waist-Line Control is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Waist-Line Control label
Go deeper

The Full Monographs Behind Waist-Line Control’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Waist-Line Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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