Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Yohimbine+ Rauwolscine Ingredients & Drug Interactions

by ALLMAX

Yohimbine+ Rauwolscine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yohimbine+ Rauwolscine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Yohimbine+ Rauwolscine is a dietary supplement by ALLMAX with 2 active ingredients. Its ingredients are commonly taken for erectile dysfunction, low sex drive, sexual performance.Based on those ingredients, 1,294 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yohimbine Hydrochloride, Rauwolscine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Yohimbine+ Rauwolscine by ALLMAX

Ask about any prescription or over-the-counter medication and we check it for interactions with Yohimbine+ Rauwolscine by ALLMAX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Yohimbine+ Rauwolscine by ALLMAX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Yohimbine+ Rauwolscine contains 2 active ingredients. Yohimbine hydrochloride is an alkaloid derived from yohimbe bark; rauwolscine is a structurally related compound.

Both are stimulant-type substances that work on your nervous system and cardiovascular system. The product also contains inactive ingredients — bovine gelatin (the capsule), magnesium stearate (a binder), and rice flour (a filler) — to hold the capsule together and allow it to be manufactured.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: rapid fat loss and lipolysis support.
  • We looked for evidence on: Obesity, Athletic performance, Weight management, Fat metabolism.
  • The closest evidence on file: Yohimbe is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Yohimbe is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Rauwolscine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Obesity.

The evidence we hold does not establish that either ingredient is reliably effective for any of its proposed uses. Yohimbine has insufficient reliable evidence for obesity, orthostatic hypotension (dizziness when standing), and antidepressant-induced sexual dysfunction.

Rauwolscine likewise shows insufficient reliable evidence for athletic performance, obesity, and sexual arousal. In short, the data does not support specific health claims for this product.

The evidence, ingredient by ingredient Yohimbe Rauwolscine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Yohimbine can cause serious heart and blood pressure effects, and the potency of yohimbe supplements is unpredictable — this makes dosing uncertain and side effects harder to forecast. Common adverse effects from yohimbine include anxiety, agitation, sweating, diarrhea, flushing, headache, increased blood pressure, increased urination, nausea, rapid heart rate, tremors, dizziness, and vomiting.

Serious but rare effects include loss of consciousness, paralysis, and seizures. Rauwolscine has very limited human safety data; no adverse effects have been formally reported orally, but because it's structurally similar to yohimbine, it could theoretically cause similar effects.

Regarding pregnancy and breastfeeding: yohimbine is considered unsafe during pregnancy (it may affect the uterus) and unsafe while breastfeeding. Rauwolscine has not been studied enough in pregnancy or lactation to know either way — the data advises against use in both situations.

If you are pregnant, planning to become pregnant, or breastfeeding, talk with your own doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Yohimbe Rauwolscine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Yohimbe, Rauwolscine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications.
  • For scale: 1,295 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your own doctor or pharmacist if you take monoamine oxidase inhibitors (MAOIs) — this is a Major severity interaction and can be dangerous. You should also review it if you take blood pressure medications (antihypertensives), tricyclic antidepressants, stimulant drugs, seizure threshold-lowering drugs, blood thinners (anticoagulants or antiplatelet drugs), calcium channel blockers, or clonidine — all are Moderate severity concerns.

The product's effect on liver enzyme activity means it can raise levels of many other drugs as well; use the search tool on this page with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is a potent stimulant with a long list of potential medication interactions and a safety profile that depends heavily on dose and individual response. If you take any prescription medications — especially blood pressure drugs, antidepressants, seizure medications, or MAOIs — you'll need to clear it with your own doctor or pharmacist before starting.

Those who are pregnant or breastfeeding should avoid it unless their healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yohimbine+ Rauwolscine, straight from the product label.

Brand ALLMAX
Barcode (UPC) 665553223537
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 296149
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yohimbine+ Rauwolscine by ALLMAX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
665553223537
IngredientAmount% DV
Yohimbine Hydrochloride3 mg--
Rauwolscine0.5 mg--

Other ingredients: Bovine Gelatin, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Professional grade supplements

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule daily just prior to exercise. Do not exceed 2 capsules daily.

Formula

Allmax Yohimbine + Rauwolscine (Alpha-Yohimbine) are the pure synthetic versions of Pausinystalia Yohimbine and Rauwolfia serpentina; thousands of times more powerful than the original herbal extracts from which they were isolated.

Formulation

Most frequently used for rapid fat loss due to its targeted ability to act on store fat, Yohimbine + Rauwolscine limits fat storage and boosts lipolysis; the release of fatty acids within stored fat. Yohimbine has an extremely high affinity for the Alpha 2-adrenoreceptor (Alpha 2-AR). These receptors (primarily in fat cells) control the rate of release of stored fat. As antagonists, Yohimbine & Rauwolscine lock on to Alpha 2 fat cell receptors. Fat storage is deactivated and rapid release of stored fat in initiated. Rauwolscine (or Alpha-Yohimbine), is an extremely rare variation of Yohimbine with a longer half-life and a more powerful Alpha 2-AR affinity. This means you need less of it to create a greater effect; it lasts longer and is the perfect complement to Yohimbine. Yohimbine + Rauwolscine is one of the most effective and efficient fat loss aids. Widely praised for its unique MOA (mechanism of action), Yohimbine + Rauwolscine is radically different than caffeine.

While caffeine is one of the best fat loss analogs out there, those who are looking to "cycle off" caffeine can use Yohimbine + Rauwolscine to affect fat loss in a completely different way.

Product of USA

Supports fat-burning Suppresses appetite

Seals/Symbols

cGMP Registered Facility

Quality Guarantee Purity & Potency Tested

Brand IP Statement(s)

Copyright 2021 Allmax Nutrition Inc. All rights reserved. Trademarks are property of their respective owners.

ALLMAX ESSENTIALS Science Innovation Quality Results

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warnings: Do not use if pregnant or nursing. Consult a medical doctor before use if you have been treated for, or diagnose with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors or any other prescription drug.

Discontinue use and consult a medical doctor if you experience unusual symptoms. Discontinue use two weeks prior to surgery. Consult a medical doctor before use if you have been treated for, or diagnose with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid or psychiatric disease, anxiety, depression, seizure disorder or stroke. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Improper use of this product will not improve results, is not advised and may cause adverse reactions listed in the warning. Consult a medical doctor before starting any diet or exercise. Do not use if inner seal is broken.

Keep out of reach of children.

California Warning: Lead is known to the State of California to cause birth defects or reproductive harm. Consuming this product can expose you to more than 0.0000005 g of lead. For more information go to www.P65Warnings.ca.gov. Prop 65

Allergen Warning: Produced in a facility that also handles milk, soy, wheat, egg, peanut, tree nuts, fish, crustacean and shellfish products.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yohimbine+ Rauwolscine by ALLMAX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yohimbine+ Rauwolscine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yohimbine+ Rauwolscine by ALLMAX

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Yohimbine Hydrochloride

Interacts with
1,125 drugs
3 mg per serving

Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription...

Yohimbine Hydrochloride monograph & interactions

Rauwolscine

Interacts with
677 drugs
0.5 mg per serving Form: Alpha-Yohimbine

Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements....

Rauwolscine monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yohimbine+ Rauwolscine by ALLMAX Drug Interactions

Want to check YOUR meds against Yohimbine+ Rauwolscine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,294Drugs
9 Major 968 Moderate 317 Minor

Ingredients driving the most interactions

Yohimbine Hydrochloride 1,125
Rauwolscine 677

Individual Drug Interactions

The ingredients in Yohimbine+ Rauwolscine interact with 1,294 drugs. Click any drug to see the details.

2 of the 2 ingredients in Yohimbine+ Rauwolscine interact with drugs. Each result below shows which ingredient is responsible. Yohimbine Hydrochloride Rauwolscine

Each ingredient & the kinds of drugs it affects

For each ingredient in Yohimbine+ Rauwolscine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Yohimbine Hydrochloride13 drug types · 1,125 drugs

Monoamine Oxidase Inhibitors (Maois)

Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.

Likelihood Likely Evidence D
Antihypertensive Drugs

Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.

Likelihood Probable Evidence D
Clonidine (Catapres)

Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Inhibitors

CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..

Likelihood Probable Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.

Likelihood Possible Evidence D
Paroxetine (Paxil)

Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.

Likelihood Probable Evidence B
Phenothiazines

Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.

Likelihood Possible Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Yohimbine Hydrochloride full monograph & interactions

Rauwolscine6 drug types · 677 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, rauwolscine may have additive coronary vasodilatory effects if used with calcium channel blockers.
In vitro, rauwolscine inhibits calcium influx in aortic smooth muscle cells.

Likelihood Possible Evidence D
Clonidine (Catapres)

Theoretically, rauwolscine may inhibit the effects of clonidine.
In animal research, rauwolscine antagonized the effects of clonidine.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.

Likelihood Possible Evidence D
Seizure Threshold Lowering Drugs

Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
In animal research, intraperitoneal rauwolscine lowered the seizure threshold level of the drug metrazol.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Rauwolscine has demonstrated stimulant effects in animal research.

Likelihood Possible Evidence D
Rauwolscine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yohimbine+ Rauwolscine, from the product label.

ALLMAX

Name
HBS INTERNATIONAL CORP.
Street Address
711 S. Carson St., Suite 4
City
Carson City
State
NV
Web Address
www.ALLMAXNUTRITION.com
Pharmacist Counseling Corner

Yohimbine+ Rauwolscine by ALLMAX: Common Questions

Does Yohimbine+ Rauwolscine by ALLMAX interact with any medications?
Yes. Based on its ingredients, Yohimbine+ Rauwolscine has a known interaction with 1,294 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yohimbine+ Rauwolscine contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does yohimbine actually do in the body?
Yohimbine is an alkaloid that acts as an alpha-2 adrenergic antagonist — it stimulates your nervous system and increases blood pressure and heart rate in a dose-dependent way. Because it also has some monoamine oxidase inhibitor activity at higher doses, it affects your brain chemistry. The result is a stimulant effect, but the potency varies widely between supplements.
Will this help me lose weight or boost athletic performance?
The evidence we have does not establish that yohimbine is reliably effective for weight loss, athletic performance, or any of its other proposed uses. For rauwolscine, the evidence is similarly insufficient. Neither ingredient has proven effectiveness in our data.
What are the most common side effects I might feel?
The most commonly reported side effects from yohimbine include anxiety, agitation, sweating, diarrhea, flushing, headache, increased blood pressure, increased urination, nausea, rapid heart rate, tremors, and dizziness. Serious but rare effects include seizures, loss of consciousness, and paralysis. Rauwolscine has not been formally studied for side effects in humans, but because it is structurally related to yohimbine, it may cause similar effects.
Can I take this if I'm on an antidepressant?
It depends on which one. Tricyclic antidepressants (a class of older antidepressants like amitriptyline or nortriptyline) have a documented Moderate interaction with yohimbine — a small clinical study showed that yohimbine doses caused severe anxiety, agitation, and tremor in people taking them. For other antidepressants and all your medications, you'll need to check with your own doctor or pharmacist before starting this product.
What is rauwolscine, and why is it in this product if there's so little data on it?
Rauwolscine is a compound structurally related to yohimbine. It has demonstrated stimulant effects in animal research but has not been formally evaluated for safety or effectiveness in humans. Manufacturers include it as a complementary stimulant ingredient, but the limited human safety data means you and your healthcare provider should treat it as an unknown element in the product.
Is this safe to take while I'm pregnant or breastfeeding?
No. Yohimbine is considered unsafe during pregnancy (it may affect the uterus) and while breastfeeding. Rauwolscine has not been studied enough to know either way, but the safety data advises against it in both situations. Talk with your own doctor or pharmacist if you are pregnant, planning to become pregnant, or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yohimbine+ Rauwolscine label
Go deeper

The Full Monographs Behind Yohimbine+ Rauwolscine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Yohimbe

Interacts with 1,125 drugs

Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...

Read the full Yohimbe monograph → Herb & supplement monograph

Rauwolscine

Interacts with 677 drugs

Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very...

Read the full Rauwolscine monograph →
Sources

Sources & How We Checked

Yohimbine+ Rauwolscine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 94 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Yohimbe 66 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  6. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  7. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
  8. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
  9. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
  10. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
  11. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
  12. Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent.Hyg. 2003;77(1):37-46.
  13. Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
  14. Cameron, O. G., Zubieta, J. K., Grunhaus, L., and Minoshima, S. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom.Med 2000;62(4):549-559. PubMed
  15. Bowes, M. P., Peters, R. H., Kernan, W. J., Jr., and Hopper, D. L. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol.Biochem.Behav. 1992;41(4):707-713.
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  11. Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. PubMed
  12. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
  13. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
  14. Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
  15. Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
  16. Swann, A. C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol.Psichiatr.Soc. 2010;19(2):120-130.
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See these in context on the Rauwolscine monograph →

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