Zuo Gui Wan Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Zuo Gui Wan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Zuo Gui Wan is a dietary supplement by Princess Lifestyle with 8 active ingredients. Its ingredients are commonly taken for sexual health and impotence, energy and fatigue, kidney and reproductive support (in traditional medicine).Based on those ingredients, 1,000 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lycium, Rehmannia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Zuo Gui Wan by Princess Lifestyle
Ask about any prescription or over-the-counter medication and we check it for interactions with Zuo Gui Wan by Princess Lifestyle — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Zuo Gui Wan by Princess Lifestyle
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Zuo Gui Wan contains 8 ingredients total, delivered in a proprietary blend. The active botanicals include cuscuta (dodder), rehmannia, achyranthes, asiatic dogwood, chinese yam, and lycium (goji).
The product is encapsulated in gelatin, with cellulose and magnesium stearate as inactive ingredients.
Does it work?
Moderate evidence
The evidence for Zuo Gui Wan's ingredients is sparse. Rehmannia is possibly effective for chronic kidney disease, but for the other conditions it's been studied in—aplastic anemia, atopic disease, osteoporosis, diabetes, and diabetic nephropathy—the evidence is insufficient to rate it.
Cuscuta and goji show insufficient evidence for depression, eczema, sunburn, cardiovascular health, high blood pressure, obesity, and quality of life. No effectiveness data is on file for achyranthes, asiatic dogwood, or chinese yam.
This is a traditional formula, but the science behind it hasn't been well established in the studies we have access to.
How safe is it?
Well-documented data
Cuscuta and rehmannia both come with limited human safety data and are best avoided during pregnancy and while breastfeeding. Goji is generally safe as a food, but medicinal supplements have less safety history; avoid medicinal amounts in pregnancy due to traditional reports of uterine effects, and use caution while breastfeeding.
High doses of cuscuta may cause intestinal cramping and diarrhea. Goji has rare case reports of allergic reactions (including anaphylaxis) and, very rarely, liver injury.
Gelatin (the capsule material) is generally well tolerated but can cause belching, bloating, and indigestion; allergic reactions to gelatin are uncommon but possible. All ingredients appear generally well tolerated at typical doses.
Meds to double-check
Major interaction found
Before taking Zuo Gui Wan, check with your doctor or pharmacist if you take warfarin or any blood thinner—goji carries a Major risk of increased bleeding. You should also confirm it's safe if you're on blood pressure medications, diabetes drugs, antiarrhythmia drugs like flecainide, or any medication metabolized by CYP2D6, CYP2C19, CYP2C9, or CYP3A4 liver enzymes (a broad group that includes many common prescriptions).
Altogether, these interactions span 1,001 individual medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a traditional Chinese formula with limited modern research backing its effectiveness. The biggest concern is if you take warfarin or other blood thinners—goji's interaction is serious and documented.
If you're on blood pressure meds, diabetes drugs, or any medication processed by your liver, check with your doctor or pharmacist before starting. Consider this product only if you've discussed it with your healthcare provider and they've cleared your specific medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Zuo Gui Wan, straight from the product label.
| Brand | Princess Lifestyle |
|---|---|
| Barcode (UPC) | 687729000773 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 21, 2022 |
| DSLD ID | 268489 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Zuo Gui Wan by Princess Lifestyle, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1000 mg | -- |
| Cuscuta | 0 NP | -- |
| Rehmannia | 0 NP | -- |
| Achyranthes | 0 NP | -- |
| Asiatic Dogwood | 0 NP | -- |
| Chinese Yam | 0 NP | -- |
| Lycium | 0 NP | -- |
| Gelatin | 0 NP | -- |
| Gelatin | 0 NP | -- |
Other ingredients: Gelatin, Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Direction: As a dietary supplement. Take 2 capsules daily with a meal.
Precautions
Warning: Keep out of reach of children.
Do not use if outer seal band or inner safety seal is missing or damaged.
Storage
Store in a cool and dry place.
Formula
Achyranthes and rehmannia formula
Formulation
Supports liver, kidney and tonifies blood
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Zuo Gui Wan by Princess Lifestyle label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Zuo Gui Wan by Princess Lifestyle
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Gelatin, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Zuo Gui Wan by Princess Lifestyle Drug Interactions
HelloPharmacist Interaction Report
Zuo Gui Wan by Princess Lifestyle contains several ingredients with documented drug interactions.
Through its rehmannia and goji content, this product poses the most serious concern: goji can significantly increase the effects of warfarin (a blood thinner) and raise the risk of bleeding—we have multiple case reports of this happening. That's a Major severity interaction you need to know about.
Read the full breakdown — every affected drug type, severity by severity
Goji also interacts with several other medication types. It may lower blood pressure when combined with blood pressure drugs (a Moderate concern), and it can theoretically inhibit liver enzymes (CYP2D6, CYP2C19, CYP2C9, and CYP3A4) that break down many common medications, potentially raising their levels—including flecainide (an antiarrhythmia drug) in at least one documented case.
These are all Moderate severity. Goji may also add to the blood-sugar-lowering effects of diabetes medications, though this is rated Minor.
Rehmannia carries Moderate interactions of its own: it may lower blood pressure further if you're already on antihypertensive drugs, and it may increase the risk of low blood sugar (hypoglycemia) if you take diabetes medications.
We could not check three other ingredients—achyranthes, asiatic dogwood, and chinese yam—because we hold no interaction data for them. Use the medication checker on this page to search for your exact drugs before starting this product, and talk with your doctor or pharmacist if you take warfarin, blood pressure medications, diabetes drugs, or any medication metabolized by those liver enzymes.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Zuo Gui Wan?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Zuo Gui Wan interact with 1,000 drugs. Click any drug to see the details.
2 of the 8 ingredients in Zuo Gui Wan interact with drugs. Each result below shows which ingredient is responsible. Lycium Rehmannia
AlmotriptanAlmogran, Axert
How Almotriptan interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Read the full Lycium + Alogliptin interactionRehmanniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Rehmannia + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
RehmanniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Rehmannia + Alogliptin, Metformin interactionLyciumAntidiabetes Drugs Minor
Interaction Summary
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Read the full Lycium + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Read the full Lycium + Alogliptin, Pioglitazone interactionRehmanniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Rehmannia + Alogliptin, Pioglitazone interactionAlpelisibPiqray
How Alpelisib interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Lycium + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Ambrisentan interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
RehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amiloride interactionLyciumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amiloride, Hydrochlorothiazide interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
Read the full Lycium + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
Read the full Lycium + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amlodipine interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
RehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine Benzoate interactionLyciumAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amlodipine Besilate interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amlodipine Besylate interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amlodipine Besylate, Benazepril interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Amlodipine, Celecoxib interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
LyciumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Lycium + Ammonium Chloride interactionRehmanniaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Ammonium Chloride interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates +1 Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Lycium + Amphetamine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Lycium + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmphetamine SulfateBenzedrine, Evekeo ODT
How Amphetamine Sulfate interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Lycium + Amphetamine Sulfate interactionAmprenavirAgenerase
How Amprenavir interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Zuo Gui Wan — through 2 ingredients. Tap an ingredient for the detail:
RehmanniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Rehmannia + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionLyciumAntidiabetes Drugs Minor
Interaction Summary
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Read the full Lycium + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApalutamideErleada
How Apalutamide interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Apixaban interactionApremilastOtezla
How Apremilast interacts with Zuo Gui Wan — through 1 ingredient. Tap an ingredient for the detail:
LyciumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Lycium + Apremilast interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Zuo Gui Wan with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Lycium
Warfarin (Coumadin)
Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).
Antihypertensive Drugs
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.
Flecainide (Tambocor)
Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.
Antidiabetes Drugs
Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.
Rehmannia
Antidiabetes Drugs
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.
Antihypertensive Drugs
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).
Brand information
Manufacturer and brand details for Zuo Gui Wan, from the product label.
Princess Lifestyle
See all Princess Lifestyle products- Name
- Princess Lifestyle, LLC
- City
- Baldwin Park
- State
- CA
- ZipCode
- 91706
Zuo Gui Wan by Princess Lifestyle: Common Questions
Does Zuo Gui Wan by Princess Lifestyle interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
What is goji, and why does it interact with so many medications?
I'm on warfarin. Can I take this product?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Zuo Gui Wan’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Dodder
Dodder (Cuscuta) is a parasitic plant whose seeds are used in traditional Chinese and Middle Eastern medicine, mainly for sexual, kidney, and energy-related complaints. Human evidence for an...
Read the full Dodder monograph → Herb & supplement monographRehmannia
Interacts with 258 drugsRehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...
Read the full Rehmannia monograph → Herb & supplement monographGoji
Interacts with 1,000 drugsGoji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune supp...
Read the full Goji monograph → Herb & supplement monographGelatin
Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most health uses, the evidence is limited or mixe...
Read the full Gelatin monograph →Sources & How We Checked
Zuo Gui Wan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Dodder 3 references
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharm PubMed
- Firoozabadi A, Zarshenas MM, Salehi A, Jahanbin S, Mohagheghzadeh A. Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression: a triple-blind randomized controlled trial study. J Evid Based Complementary Altern Med
Rehmannia 3 references
- Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
- Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
- Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.
Goji 14 references
- Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
- Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
- Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
- Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
- Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
- Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
- Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
- Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
- Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
- Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
- Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
- Zhang J, Tian L, Xie B. Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.). Toxicol Rep. 2015;2:1209-1212. PubMed
Gelatin 11 references
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol 1969;33:111-25. PubMed
- Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. PubMed
- Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103:200-2.
- Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allerg PubMed
- Sakaguchi M, Inouye S. Anaphylaxis to gelatin-containing rectal suppositories. J Allergy Clin Immunol 2001;108:1033-4. PubMed
- PDR Electronic Library. Montvale, NJ: Medical Economics Company, Inc., 2001.
- de la Fuente Tornero E, Vega Castro A, de Sierra Hernández PÁ, et al. Kounis syndrome during anesthesia: Presentation of indolent systemic mastocytosis: A case report. A Case Rep. 2017;8(9):226-228. PubMed
- Ventura Spagnolo E, Calapai G, Minciullo PL, Mannucci C, Asmundo A, Gangemi S. Lethal anaphylactic reaction to intravenous gelatin in the course of surgery. Am J Ther. 2016;23(6):e1344-e1346. PubMed
- Li Y, He H, Yang L, Li X, Li D, Luo S. Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia. Int J Hematol. 2016;104(5):559-565. PubMed
- Coury JR, Skaggs KF, Marciano GF, et al. Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases. JBJS Case Connect 2022;12(1). PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC