Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.
Walgreens Anti Itch Cream 20 mg/g; 1 mg/g Cream — NDC 0363-2315-28 (Billing 00363-2315-28)
by Walgreens Company · 1 TUBE in 1 CARTON / 28 g in 1 TUBE
This is a package of Walgreens Anti Itch Cream 20 mg/g; 1 mg/g Cream from Walgreens Company, marketed since May 2014 and currently FDA-listed. It is this product's only package size.
NDC 00363-2315-28
🏷️ FDA NDC (as labeled)
0363-2315-28
billing pads the labeler segment with a zero
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
0363-2315-28
Product NDC
0363-2315
11-digit billing NDC
00363231528
RxCUI
1087026
UNII
TC2D6JAD40, FM5526K07A
UPC
0311917164106
Application #
M017
SPL Set ID
b545553a-283a-48af-adc5-763758a9ff24
Established class (EPC)
Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action
Histamine H1 Receptor Antagonists
Physiologic effect
Decreased Copper Ion Absorption
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2014-05-05
Route
TOPICAL
Dosage form
CREAM
Substance
DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Quick answers
- RxCUI (RxNorm): 1087026
Why two NDCs?
The FDA registers this code as 0363-2315-28 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00363-2315-28. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Pharmacologic class
Histamine-1 Receptor Antagonist
Drug family (ATC)
Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works
Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
📖 About the active ingredient: Diphenhydramine Hydrochloride; Zinc Acetate MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗🧪 What is this product?
Walgreens Anti Itch Cream is a topical cream made available as an over-the-counter monograph product containing diphenhydramine hydrochloride and zinc acetate. Diphenhydramine is an antihistamine commonly used in topical products to help reduce itching and skin irritation. Zinc acetate functions as an astringent and is often included in anti-itch formulations to help soothe and dry irritated skin. This product is applied directly to the skin to temporarily help relieve minor itching.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
💬 Questions about Anti Itch Cream?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 2, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 00363-2315-28 You're viewing this Main listing | 1 TUBE in 1 CARTON / 28 g in 1 TUBE | 2014-05-05 | — | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense itch relief 2 g/100g; .1 g/100g 00113-0622-64 | L. | 1 tube | $0.058 | — | Availability likely | — |
| Banophen 2 g/100g; .1 g/100g 00904-5354-31 | Major | 1 tube | $0.058 | — | Availability likely | — |
| diphenhydramine hcl and zinc acetate 2 g/100g; .1 g/100g 45802-0358-03 | Padagis | 1 tube | $0.058 | — | Availability likely | — |
| GNP Extra Strength Anti-Itch Cream .1 g/100g; 2 g/100g 46122-0804-36 | Amerisource | 1 tube | $0.058 | — | Availability likely | — |
| leader anti itch 2 g/100g; .1 g/100g 70000-0388-01 | Cardinal | 1 tube | $0.058 | — | Availability likely | — |
| foster and thrive anti itch cream 2 g/100g; .1 g/100g 70677-1289-01 | Strategic | 1 tube | $0.058 | — | Availability likely | — |
| Anti-Itch 20 mg/g; 1 mg/g 24385-0210-03 | Amerisource | 1 tube | $0.130 | — | Discontinued | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 70677-1213-01 | STRATEGIC | 1 tube | $0.130 | — | FDA listed | — |
| Walgreens Anti Itch Cream 20 mg/g; 1 mg/gthis 00363-2315-28 | Walgreens | 1 tube | — | — | FDA listed | — |
| Dr. Sheffield Anti Itch Cream 20 mg/g; 1 mg/g 11527-0069-04 | Sheffield | 1 tube | — | — | FDA listed | — |
| Anti-itch 20 mg/g; 1 mg/g 11673-0895-28 | Target | 1 tube | — | — | FDA listed | — |
| Rite Aid Extra Strength Itch Stopping 1 mg/g; 20 mg/g 11822-6614-01 | Rite | 1 tube | — | — | FDA listed | — |
| signature care itch relief 2 g/100g; .1 g/100g 21130-0154-64 | Safeway | 1 tube | — | — | FDA listed | — |
| anti itch 2 g/100g; .1 g/100g 30142-0582-64 | Kroger | 1 tube | — | — | FDA listed | — |
| Shopko Anti-Itch 20 mg/g; 1 mg/g 37012-0089-02 | Shopko | 1 tube | — | — | FDA listed | — |
| itch relief 2 g/100g; .1 g/100g 37808-0622-64 | H | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 1 mg/g; 20 mg/g 41226-0888-02 | Kroger | 1 tube | — | — | FDA listed | — |
| Anti Itch 2 g/100g; .1 g/100g 41250-0622-64 | Meijer | 1 tube | — | — | FDA listed | — |
| Equate Anti Itch 2 g/100g; .1 g/100g 49035-0622-64 | Wal-Mart | 1 tube | — | — | FDA listed | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 51672-2089-02 | Sun | 1 tube | — | — | FDA listed | — |
| CAREALL Anti-Itch 20 mg/g; 1 mg/g 51824-0088-01 | New | 35 g | — | — | FDA listed | — |
| Extra Strength Itch Stopping 20 mg/g; 1 mg/g 52000-0071-02 | Universal | 1 tube | — | — | FDA listed | — |
| Discount Drug Mart Extra Strength Itch Stopping 20 mg/g; 1 mg/g 53943-0258-01 | Discount | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100g 55621-0007-01 | Zhejiang | 1 tube | — | — | FDA listed | — |
| ItchZap 20 mg/g; 1 mg/g 57237-0352-28 | Rising | 1 tube | — | — | FDA listed | — |
| Itch Relief 2 g/100g; .1 g/100g 59779-0708-64 | CVS | 1 tube | — | — | FDA listed | — |
| Itch Relief Cream 2 g/100g; .1 g/100g 68016-0163-01 | Pharmacy | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100g 69396-0025-05 | Trifecta | 1 tube | — | — | FDA listed | — |
| Itch stopping Cream 2 g/100g; .1 g/100g 69396-0150-01 | Trifecta | 1 tube | — | — | FDA listed | — |
| itch relief 1 mg/g; 20 mg/g 69452-0449-37 | Bionpharma | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100g 69571-0005-02 | FRONT | 1 tube | — | — | FDA listed | — |
| CVS Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69842-0321-28 | CVS | 1 tube | — | — | FDA listed | — |
| Benadryl Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69968-0223-01 | Kenvue | 1 tube | — | — | FDA listed | — |
| TheraCare 2% Diphenhydramine Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0014-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Caring Mill Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0055-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100g 83324-0039-01 | Chain | 1 tube | — | — | FDA listed | — |
| Savvy Itch Stopping 2 g/100g; .1 g/100g 83650-0102-01 | Savvy | 35.4 g | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
2014
On the market since
May 2014
📍
2026
Currently FDA-listed
12 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Sep 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII 936JST6JCN
Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
-
UNII 2968PHW8QP
A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
-
UNII H5RIZ3MPW4
A chemical preservative used to prevent bacterial and fungal growth in medicines. It helps extend shelf life and maintain product safety during storage and use.
-
UNII A2I8C7HI9T
Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
-
UNII NBX892EA57
A synthetic compound made by combining polyethylene glycol with stearic acid. It acts as an emulsifier and surfactant to help mix oil and water-based ingredients, and improves how the medicine dissolves and spreads in the body.
-
UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
-
UNII MZM1I680W0
Propylene glycol stearate is a waxy substance made by combining stearic acid with propylene glycol. It acts as an emulsifier to help blend oil and water ingredients, and also serves as a thickener or stabilizer in the medicine.
-
UNII Z8IX2SC1OH
Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
-
UNII 1Q73Q2JULR
Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
-
UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
10 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesCetyl Alcohol, Citric Acid, Diazolldinyl Urea, Glyceral Stearate, Methylparaben, Polyethylene Glycol Monsterate 1000, Sodium Citrate, Water (Purified)
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerWalgreens Company
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code00363
First marketedMay 2014
Product typeHuman Otc Drug
Portfolio62 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
📄 Keep Out of Reach of Children
📄 Questions or Comments
📄 Package Label / Principal Display Panel
🎯 Indications and Usage ▾
Uses For temporary relief from pain and itching associated with : insect bites minor burns sunburn minor skin irritations rashes due to poison ivy, poison oak, and poison sumac Dries the oozing and weeping of poison ivy oak sumac
⏱️ Dosage and Administration ▾
Directions do not use more than directed adults and children 2 years of age and older; apply to affected areas not more than 3 to 4 times daily children under 2 years of age , consult a doctor Other Information Store at controlled room temperature 20°-25°C (68° - 77°F) Close the cap tightly after use
⚠️ Warnings ▾
Warnings For external use only Do not use on large areas of the body with any other product containing diphenhydramine , even one taken by the mouth. Ask a Doctor before use on chicken pox on measles When using this product avoid contact with eyes. Stop use and ask a doctor if conditions worsen or does not improve within 7 days symptoms persist for more than 7 days or clear up and occur agian within a few days
🧪 Active Ingredient ▾
Active ingredients Diphenhydramine hydrochloride 2% Zinc Acetate 0.1%
🧪 Inactive Ingredients ▾
Inactive ingredients Cetyl Alcohol, Citric Acid, Diazolldinyl Urea, Glyceral Stearate, Methylparaben, Polyethylene Glycol Monsterate 1000, Sodium Citrate, Water (Purified)
🎯 Purpose ▾
Purpose Topical analgesic Skin protectant
📄 Keep Out of Reach of Children ▾
Keep this and all drugs out of the reach of children. If swallowed get medical help or contact a Poison Control Center immediately.
📄 Questions or Comments ▾
Other Information Store at controlled room temperature 20° -25°C (68°-77°F) Close Cap tightly after use
📄 Package Label / Principal Display Panel ▾
Principal Display Panel Walgreens NDC 0363-2315-28 Anti Itch Cream Diphenhydramine HCL 2.0% Topical Analgesic Zinc Acetate 0.1% Skin Protectant NET WT 1.0 oz (28g) 5551974_AntiItchCream_BOX 2802478_AntiItchCream_TUBE
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Anti Itch Cream — the ingredient across all brands.
Top reported reactions
Age at onset
Reporter sex
Male · 42%
Female · 58%
Unknown · 0%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Walgreens Company. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Walgreens Company is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.