Home › NDC Lookup › Ingredients › Naproxen Sodium › 45802-0490-75
Naproxen Sodium 220 mg Tablet, Film Coated, 90-count — NDC 45802-0490-75 package photo

Naproxen Sodium 220 mg Tablet, Film Coated, 90-count

by Padagis Israel Pharmaceuticals Ltd · 1 BOTTLE in 1 CARTON (45802-490-75) / 90 TABLET, FILM COATED in 1 BOTTLE
NDC 45802-0490-75
🏷️ FDA NDC (as labeled) 45802-490-75 billing pads the product segment with a zero
This package
Contains90-count Cost per ea$0.0669 NADAC Per package$6.02 / 90 tablets Pack sizes3 compare ↓
Also priced by: Medicaid pays $0.1777/unit — full pricing hub ↓
Also comes in: 50 tablets 45802-0490-71 100 tablets 45802-0490-78
OTC Generic On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Naproxen Sodium (different manufacturers) — 2 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Mar 13, 2025 — CGMP Deviations (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0346-2025
Class II · Nov 7, 2023 — Labeling: Label Mix-Up-Indomethacin bottles may be labeled as Naproxen (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0124-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

🆔 Identity & classification

FDA NDC (as labeled) 45802-490-75
Product NDC 45802-490
11-digit billing NDC 45802049075
NCPDP billing unit EA — each (per item)
RxCUI 849574
UNII 9TN87S3A3C
Application # ANDA074661
SPL Set ID cdb60f74-ce23-4015-90eb-b23a2275f6cb
Established class (EPC) Anti-Inflammatory Agents; Nonsteroidal Anti-inflammatory Drug
Mechanism of action Cyclooxygenase Inhibitors
Chemical class Non-Steroidal
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2014-04-11
Route ORAL
Dosage form TABLET, FILM COATED
Substance NAPROXEN SODIUM
GPI-14 66100060100303
GPI class Naproxen Sodium
GCN Seq No 021980
GCN 47132
HICL code 003726
Ingredient (HICL) Naproxen Sodium
HIC1 code S
Therapeutic class — broad (HIC1) Locomotor System
HIC2 code S2
Therapeutic class — intermediate (HIC2) Drugs Acting Principally On Joints
HIC3 code S2B
Therapeutic class — specific (HIC3) Nsaids, Cyclooxygenase Inhibitor Type Analgesics
AHFS code 28:08.04.04
AHFS class Reversible Cox-1/Cox-2 Inhibitors
FDB label name NAPROXEN SODIUM 220 MG TABLET
FDB brand name Naproxen Sodium
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 45802-490-75 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 45802-0490-75. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Nonsteroidal Anti-inflammatory Drug class.

Pharmacologic class Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Propionic acid derivatives, Antiinflammatory products for vaginal administration, Antiinflammatory preparations, non-steroids for topical use
How it works Cyclooxygenase Inhibitors
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerPadagis Israel Pharmaceuticals Ltd
Application holderL PERRIGO CO
FDA applicationANDA074661 (ANDA)
Labeler code45802
First marketedApr 2014
Product typeHuman Otc Drug
Portfolio175 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name NAPROXEN SODIUM 220 MG TABLET Ingredient Naproxen Sodium
📖 What it is MedlinePlus · NLM

Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription naproxen tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of th...

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • They're very similar — naproxen sodium is just the salt form of naproxen, and it dissolves in water more quickly. That means your body absorbs naproxen sodium a bit faster, so it t...
  • What's the difference between naproxen and naproxen sodium — are they the same thing?
  • You can take it either way, but taking it with food, milk, or a full glass of water is a good idea because it helps protect your stomach. Naproxen can irritate the lining of your s...
  • Can I take naproxen on an empty stomach, or do I need to eat first?
📖 Read our full Naproxen guide →
1
Nutrient depletion considerations

Naproxen Sodium may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Naproxen Sodium nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color Blue
ShapeRound
ImprintL490
Size1 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 4AQJ3LG584
    A synthetic blue dye combined with aluminum to create a stable colorant. It's used in medicines and supplements to add blue color or create specific shades for product identification and appearance.
  • UNII 3NXW29V3WO
    Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII 3WJQ0SDW1A
    Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 7SEV7J4R1U
    A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
  • UNII 15FIX9V2JP
    Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesFD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.067 $6.02 / 90 tablets
Medicaid paysCMS SDUD · 12 mo $0.1777 $15.99 / 90 tablets
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Sep 2022 Jan 2024 Mar 2026 Aug 2026 $0.068 $0.059
▲ Up 6% over the last 15 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leader All Day Pain Relief 220 mg 70000-0171-01 Cardinal 100 tablets $0.059 — Discontinued save 12%
Rugby All Day Relief 220 mg 00536-1093-01 Rugby 100 tablets $0.063 — Discontinued save 7%
rugby all day relief 220 mg 00536-1094-01 Rugby 100 tablets $0.065 — Discontinued save 3%
Naproxen Sodium 220 mg 63868-0465-01 Chain 100 tablets $0.065 — FDA listed save 3%
Good Sense Naproxen Sodium 220 mg 00113-0901-62 L. 24 tablets $0.067 — Availability likely —
Good Sense Naproxen Sodium 220 mg 00113-4368-62 L. 24 tablets $0.067 — Availability likely —
Naproxen Sodium 220 mgthis 45802-0490-75 Padagis 90 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0562-71 Amerisource 50 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0564-71 Amerisource 50 tablets $0.067 — Availability likely —
Naproxen sodium 220 mg 69230-0329-01 Camber 100 tablets $0.067 — Availability likely —
Leader All Day Pain Relief 220 mg 70000-0201-02 Cardinal 50 tablets $0.067 — Availability likely —
foster and thrive all day pain relief 220 mg 70677-1137-01 Strategic 50 tablets $0.067 — Availability likely —
good sense naproxen sodium 220 mg 00113-1412-71 L. 50 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0041-01 Bayer 175 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-0111-01 Bayer 10 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0112-01 Bayer 175 tablets — — FDA listed —
Aleve 220 mg 00280-0113-01 Bayer 10 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-0114-01 Bayer 200 tablets — — FDA listed —
Aleve Caplets Soft Grip Arthritis 220 mg 00280-0115-01 Bayer 270 tablets — — FDA listed —
Aleve Caplets Easy Open Arthritis 220 mg 00280-0130-01 Bayer 90 tablets — — FDA listed —
Aleve Easy Open Arthritis 220 mg 00280-0131-01 Bayer 200 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-6000-01 Bayer 24 tablets — — FDA listed —
Aleve 220 mg 00280-6010-01 Bayer 100 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6020-02 Bayer 90 tablets — — FDA listed —
Aleve Caplets - Easy Open Arthritis Cap 220 mg 00280-6050-01 Bayer 100 tablets — — FDA listed —
Aleve Easy Open Arthritis Cap 220 mg 00280-6060-20 Bayer 200 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6070-40 Bayer 40 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-6092-02 Bayer 130 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-8252-10 Bayer 10 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-0368-61 Walgreen 600 tablets — — Discontinued —
all day pain relief 200 mg 00363-0938-82 Walgreen 200 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-6099-01 WALGREENS 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-9608-01 WALGREENS 100 tablets — — FDA listed —
Back And Muscle Pain 220 mg 00363-9609-01 WALGREENS 100 tablets — — FDA listed —
Bayer Aleve 220 mg 00924-6000-00 Acme 1 tablet — — FDA listed —
up and up naproxen sodium 220 mg 11673-0368-71 Target 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 11673-0764-05 TARGET 50 tablets — — FDA listed —
up and up naproxen sodium 220 mg 11673-0909-75 Target 90 tablets — — FDA listed —
Back and Muscle Pain 220 mg 11822-4170-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 11822-4171-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 11822-6040-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 21130-0061-05 Safeway, 50 tablets — — FDA listed —
Naproxen 220 mg 21130-0062-05 Safeway, 50 tablets — — FDA listed —
signature care naproxen sodium 220 mg 21130-0180-62 Safeway 24 tablets — — Discontinued —
Naproxen Sodium 220 mg 21130-0593-79 Safeway 400 tablets — — FDA listed —
Pain Relief 220 mg 21130-0608-05 BETTER 50 tablets — — FDA listed —
Naproxen 220 mg 21130-0674-52 Better 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0690-05 BETTER 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0856-52 Better 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 25000-0141-02 MARKSANS 3840 tablets — — FDA listed —
Naproxen Sodium 220 mg 25000-0144-02 MARKSANS 3840 tablets — — FDA listed —
Flanax 220 mg 27854-0160-00 Belmora 100 tablets — — Discontinued —
Flanax Menstrual Pain Reliever 220 mg 27854-0165-10 Belmora 10 tablets — — FDA listed —
AnaDent 220 mg 27854-0170-01 Belmora 24 tablets — — FDA listed —
Flanax Pain Reliever/Fever reducer 220 mg 27854-0505-01 Belmora 24 tablets — — FDA listed —
Belmora Flanax 220 mg 27854-0555-01 Belmora 24 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 27854-0700-01 Belmora 24 tablets — — FDA listed —
Ana-Dent PAIN RELIEF 220 mg 27854-0701-01 Belmora 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 30142-0954-10 Kroger 100 tablets — — FDA listed —
Topcare All Day Pain Relief 220 mg 36800-0140-82 Topco 200 tablets — — FDA listed —
TopCare All Day Pain Relief 220 mg 36800-0368-62 Topco 24 tablets — — FDA listed —
Topcare All Day Pain Relief 220 mg 36800-0490-62 Topco 24 tablets — — FDA listed —
topcare back and muscle pain 220 mg 36800-0696-75 Topco 90 tablets — — FDA listed —
All Day Pain Relief 220 mg 37808-0068-24 H 24 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0631-82 H 200 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0652-62 H 24 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0713-79 H 400 tablets — — FDA listed —
Naproxen Sodium 220 mg 37835-0594-01 Bi-Mart 100 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0511-62 United 24 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0707-71 United 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 41226-0609-05 Kroger 50 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0313-82 Meijer 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0477-62 Meijer 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0680-71 Meijer 50 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0818-62 Meijer 24 tablets — — FDA listed —
Care One Naproxen Sodium 220 mg 41520-0349-82 American 200 tablets — — FDA listed —
CareOne Naproxen Sodium 220 mg 41520-0507-48 American 90 tablets — — Discontinued —
Care One Naproxen Sodium 220 mg 41520-0533-71 American 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0245-01 HYVEE 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0844-01 HYVEE 24 tablets — — FDA listed —
First Aid Direct All Day Pain Relief 220 mg 42961-0122-02 Cintas 1 tablet — — FDA listed —
Naproxen Sodium 220 mg 43063-0909-20 PD-Rx 20 tablets — — FDA listed —
Naproxen Sodium Caplets 220 mg 43598-0058-29 Dr 200 tablets — — FDA listed —
Naproxen Sodium Headache Pain Caplets 220 mg 43598-0059-52 Dr.Reddy's 225 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain Caplets 220 mg 43598-0060-52 Dr.Reddy's 225 tablets — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0072-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0074-01 Dr.Reddy's 100 tablets — — FDA listed —
Belmora Flanax 220 mg 47682-0037-50 Unifirst 1 tablet — — FDA listed —
Medique Mediproxen 220 mg 47682-0237-33 Unifirst 1 tablet — — FDA listed —
Bayer Aleve 220 mg 47682-0488-50 Unifirst 50 tablets — — FDA listed —
Medique at Home Mediproxen 220 mg 47682-0737-50 Unifirst 1 tablet — — FDA listed —
Calmadol Pain Reliever 220 mg 48201-0007-24 GRANDALL 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 49483-0608-00 TIME 6500 tablets — — FDA listed —
Naproxen Sodium 220 mg 49483-0609-00 TIME 6500 tablets — — FDA listed —
Naproxen Sodium 220 mg 50090-0685-01 A-S 10 tablets — — FDA listed —
Medique Mediproxen 220 mg 50090-2388-00 A-S 1 tablet — — FDA listed —
rugby all day relief 220 mg 50090-3356-00 A-S 30 tablets — — FDA listed —
Naproxen 220 mg 50844-0261-08 L.N.K. 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 50844-0417-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Headache Pain 220 mg 50844-0471-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Sodium 220 mg 50844-0604-09 L.N.K. 5 tablets — — FDA listed —
Naproxen Back and Muscle Pain 220 mg 50844-0714-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0608-90 CVS 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0761-20 CVS 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0762-70 CVS 270 tablets — — FDA listed —
Back and Muscle Pain 220 mg 51316-0817-08 CVS 24 tablets — — FDA listed —
CAREALL Naproxen 220 mg 51824-0072-01 New 100 tablets — — FDA listed —
CAREALL Naproxen Sodium 220 mg 51824-0109-01 New 100 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 53185-0394-50 Athlete's 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 53185-0604-12 Athlete's 100 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 53329-0688-30 Medline 100 tablets — — Discontinued —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0191-05 Amneal 500 tablets — — FDA listed —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0192-05 Amneal 500 tablets — — FDA listed —
Naproxen 220 mg 53943-0144-02 DISCOUNT 50 tablets — — FDA listed —
Naproxen 220 mg 53943-0145-02 DISCOUNT 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0272-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0273-01 Dr. 100 tablets — — FDA listed —
exchange select naproxen sodium 220 mg 55301-0368-71 Army 50 tablets — — FDA listed —
Naproxen 220 mg 55319-0406-52 Family 90 tablets — — Discontinued —
Naproxen 220 mg 55319-0717-08 Family 24 tablets — — FDA listed —
Rapidol Naproxen 220 mg 55758-0048-24 Pharmadel 24 tablets — — FDA listed —
DG Health Naproxen Sodium 220 mg 55910-0481-62 Dolgencorp 24 tablets — — FDA listed —
DG Health Naproxen Sodium 220 mg 55910-0490-62 Dolgencorp 24 tablets — — FDA listed —
dg health naproxen sodium 220 mg 55910-0500-71 Dolgencorp 50 tablets — — Discontinued —
dg health naproxen sodium 220 mg 55910-0729-62 Dolgencorp 24 tablets — — FDA listed —
All Day Relief 220 mg 56062-0368-62 Publix 24 tablets — — FDA listed —
all day relief 220 mg 56062-0490-71 Publix 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 57344-0145-01 AAA 24 tablets — — FDA listed —
Naproxen 220 mg 57896-0954-01 Geri-Care 100 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0735-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0736-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0737-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0738-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0739-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0819-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0845-21 Aurohealth 100 tablets — — FDA listed —
Artridol 220 mg 59428-0604-08 Zapotol 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 59726-0169-15 P 15 tablets — — FDA listed —
naproxen sodium 220 mg 59779-0914-75 CVS 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 61504-0145-02 AMERIFOODS 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0327-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0328-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0728-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0729-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0761-42 Granules 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0762-42 Granules 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 63187-0596-24 Proficient 24 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 63187-0794-20 Proficient 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 63868-0466-01 Chain 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0144-01 VALU 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0245-01 VALU 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0444-01 VALU 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0445-01 VALU 24 tablets — — FDA listed —
kirkland signature naproxen sodium 220 mg 63981-0368-79 Costco 400 tablets — — FDA listed —
Aleve 220 mg 66715-5103-00 Lil' 60 tablets — — FDA listed —
24/7 Life by 7-Eleven Naproxen Sodium 220 mg 66715-5428-04 Lil' 24 tablets — — FDA listed —
Aleve 220 mg 66715-6402-08 Lil' 30 tablets — — FDA listed —
Aleve, TRAVEL BASIX 220 mg 66715-6411-02 Lil' 2 tablets — — FDA listed —
Aleve 220 mg 66715-6502-02 Lil' 2 tablets — — FDA listed —
Aleve 220 mg 66715-9702-01 Lil' 1 tablet — — Discontinued —
Lil Drug Store Pain Relief All Day 220 mg 66715-9740-04 Lil' 12 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0138-50 WinCo 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0140-10 WinCo 100 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 67751-0125-01 Navajo 2 tablets — — FDA listed —
Aleve 220 mg 67751-0144-03 Navajo 1 tablet — — FDA listed —
Naproxen 220 mg 68071-5039-01 NuCare 21 tablets — — FDA listed —
Naproxen Sodium 220 mg 68196-0255-20 SAM'S 400 tablets — — FDA listed —
Berkley and Jensen Naproxen Sodium 220 mg 68391-0368-79 BJWC 400 tablets — — FDA listed —
Naproxen 220 mg 68788-7572-02 Preferred 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 68788-8443-02 Preferred 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 68998-0144-03 Marc 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 68998-0145-03 Marc 100 tablets — — FDA listed —
Naproxen Caplets All day relief for pain 220 mg 69168-0362-07 Allegiant 10 tablets — — FDA listed —
Naproxen Caplets 220 mg 69168-0394-24 Allegiant 24 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 69168-0395-17 Allegiant 300 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 69197-0394-24 Command 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 69517-0109-02 HealthLife 32 tablets — — FDA listed —
Proxen Np 660 220 mg 69729-0123-12 OPMX 12 tablets — — FDA listed —
Naproxen Sodium 220 mg 69842-0811-62 CVS 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 69848-0010-01 Granules 10 tablets — — FDA listed —
Aleve 220 mg 70264-0011-01 R 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 71141-0182-32 Lidl 100 tablets — — FDA listed —
Naproxen 220 mg 71205-0595-30 Proficient 30 tablets — — FDA listed —
Naproxen Sodium 220 mg 71335-1061-01 Bryant 20 tablets — — FDA listed —
Naproxen 220 mg 71335-1282-01 Bryant 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 71335-2584-01 Bryant 20 tablets — — FDA listed —
Rugby All Day Relief 220 mg 71335-3009-01 Bryant 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0144-01 Harris 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0145-01 Harris 24 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0331-62 Amazon.com 24 tablets — — Discontinued —
Amazon Basic Care Naproxen Sodium 220 mg 72288-0366-20 Amazon.com 200 tablets — — FDA listed —
basic care naproxen sodium 220 mg 72288-0368-75 Amazon.com 90 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0489-75 Amazon.com 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 72789-0543-14 PD-Rx 14 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0005-10 WALMART 40 tablets — — Discontinued —
Naproxen Sodium 220 mg 79903-0231-50 WALMART 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 79903-0232-90 WALMART 90 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0389-50 Walmart 50 tablets — — FDA listed —
All Day Back and Muscle Pain Relief 220 mg 79903-0609-09 Walmart 90 tablets — — FDA listed —
betr headache pain relief 220 mg 80267-0001-71 Live 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 81522-0045-05 FSA 200 tablets — — FDA listed —
Pain Relief 220 mg 82501-1576-01 Gobrands, 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0108-01 CHAIN 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0109-01 CHAIN 100 tablets — — FDA listed —
Aleve Caplets 220 mg 85237-1832-01 Select 1 tablet — — FDA listed —
Medique Mediproxen 220 mg 85766-0121-01 Sportpharm 1 tablet — — FDA listed —
Dr Simi All Day Pain Relief 220 mg 85786-0104-24 Farmacias 24 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 85828-0394-92 Grocery 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 00363-7510-20 Walgreens 20 tablets — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0071-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0073-01 Dr.Reddy's 100 tablets — — FDA listed —
naproxen sodium 220 mg 72288-0988-75 Amazon.com 90 tablets — — FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2014
On the market since
Apr 2014
📍
2026
Currently FDA-listed
12 years listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🗺️ Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 45802-0490-75, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q4 2025 · 4 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
5.4K
Units reimbursed last 4 qtrs
270.9K
Gross reimbursed last 4 qtrs
$48.2K
Avg / prescription
$8.86
Avg / unit
$0.1777
Latest quarter Q4 2025
1.5KRx
Medicaid pays / ea
$0.1777
gross reimbursed
vs
NADAC / ea
$0.0669
acquisition cost
=
Spread
+$0.1108
+166% vs cost
What Medicaid paid per ea (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
49% FFS 51% MCO
Fee-for-service · 2,676 Rx Managed care · 2,756 Rx
State Medicaid map
Alaska: no data reported AK Maine: 5,080 units · 364 per 100k residents ME Washington: 18,858 units · 241 per 100k residents WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 25,861 units · 451 per 100k residents MN Wisconsin: 30,238 units · 512 per 100k residents WI Michigan: 10,936 units · 109 per 100k residents MI New York: no data reported NY Vermont: 1,422 units · 220 per 100k residents VT New Hampshire: 831 units · 59.3 per 100k residents NH Oregon: 20,146 units · 476 per 100k residents OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: 4,893 units · 39.0 per 100k residents IL Indiana: 22,554 units · 329 per 100k residents IN Ohio: 19,300 units · 164 per 100k residents OH Pennsylvania: 14,912 units · 115 per 100k residents PA New Jersey: 2,668 units · 28.7 per 100k residents NJ Massachusetts: 10,229 units · 146 per 100k residents MA California: 36,666 units · 94.1 per 100k residents CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 6,987 units · 353 per 100k residents NE Missouri: 11,439 units · 185 per 100k residents MO Kentucky: 12,065 units · 267 per 100k residents KY West Virginia: no data reported WV Virginia: 3,993 units · 45.8 per 100k residents VA Maryland: no data reported MD Connecticut: 2,659 units · 73.5 per 100k residents CT Rhode Island: no data reported RI Arizona: 3,825 units · 51.5 per 100k residents AZ New Mexico: no data reported NM Kansas: 5,334 units · 181 per 100k residents KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: no data reported DC Hawaii: no data reported HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
28.7512
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Wisconsin 512 /100k
2 Oregon 476 /100k
3 Minnesota 451 /100k
4 Maine 364 /100k
5 Nebraska 353 /100k
6 Indiana 329 /100k
7 Kentucky 267 /100k
8 Washington 241 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

💊 Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
90 tablets this page45802-0490-75 5,432 Rx · $48,150
50 tablets45802-0490-71 978 Rx · $8,258
100 tablets45802-0490-78 No Medicaid data
Drug total (last 4 qtrs): 6,410 Rx · 315,663 units · $56,408 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

📊 Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Naproxen Sodium — the program that covers self-administered drugs. 4 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Naproxen Sodium. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$441.8K
Claims incl. refills
15.2K
Beneficiaries
11.4K
Spend / beneficiary
$38.70
Spend / claim
$29.13
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
45802-0490-71 1 BOTTLE in 1 CARTON (45802-490-71) / 50 TABLET, FILM COATED in 1 BOTTLE $0.0590 / ea $2.95 2014-04-11 Discontinued by firm
45802-0490-75 You're viewing this 1 BOTTLE in 1 CARTON (45802-490-75) / 90 TABLET, FILM COATED in 1 BOTTLE $0.0669 / ea $6.02 2021-12-02 Active
45802-0490-78 1 BOTTLE in 1 CARTON (45802-490-78) / 100 TABLET, FILM COATED in 1 BOTTLE $0.0648 / ea $6.48 2014-04-11 Discontinued by firm

Per ea, this pack runs about 13% above the cheapest pack (NDC 45802-0490-71, $0.0590 vs $0.0669 NADAC).

In Medicaid, this is the most-dispensed pack of this product — about 85% of fills over the last four reported quarters. See all packs ↓

Pack size FAQ

What quantity is in NDC 45802-0490-75?
NDC 45802-0490-75 is a 90-count package — 1 bottle in 1 carton / 90 tablet, film coated in 1 bottle.
What is the difference between NDC 45802-0490-75 and NDC 45802-0490-71?
Both are Naproxen Sodium 220 mg Tablet, Film Coated — the drug itself is identical. NDC 45802-0490-75 is the 90-count package, while NDC 45802-0490-71 is the 50 tablets package. Per-ea NADAC also differs: $0.0669 here vs $0.0590 for the 50 tablets pack.
What NDC number is used to bill for this package of Naproxen Sodium 220 mg Tablet, Film Coated?
Bill NDC 45802-0490-75 — the 11-digit billing format is 45802049075. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 35 words ▾

Uses • temporarily relieves minor aches and pains due to: • minor pain of arthritis • muscular aches • backache • menstrual cramps • headache • toothache • the common cold • temporarily reduces fever

⏱️ Dosage and Administration 89 words ▾

Directions • do not take more than directed • the smallest effective dose should be used • drink a full glass of water with each dose Adults and children 12 years and older • take 1 tablet every 8 to 12 hours while symptoms last • for the first dose you may take 2 tablets within the first hour • do not exceed 2 tablets in any 8- to 12-hour period • do not exceed 3 tablets in a 24-hour period Children under 12 years • ask a doctor

⚠️ Warnings ~2 min read ▾

Warnings Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you: • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Heart attack and stroke warning : NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.

Do not use • if you have ever had an allergic reaction to any other pain reliever/fever reducer • right before or after heart surgery Ask a doctor before use if • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic • you have problems or serious side effects from taking pain relievers or fever reducers Ask a doctor or pharmacist before use if you are • under a doctor’s care for any serious condition • taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin • taking any other drug When using this product • take with food or milk if stomach upset occurs Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • you have symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • you have difficulty swallowing • it feels like the pill is stuck in your throat • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use.

It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

📦 Storage and Handling 23 words ▾

Other information • each tablet contains: sodium 22 mg • store at 20-25°C (68-77°F). Avoid high humidity and excessive heat above 40°C (104°F).

🧪 Active Ingredient 16 words ▾

Active ingredient (in each tablet) Naproxen sodium 220 mg (naproxen 200 mg) (NSAID)* *nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 19 words ▾

Inactive ingredients FD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

🎯 Purpose 4 words ▾

Purposes Pain reliever/fever reducer

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 45802-0486-78 · Padagis 45802-0491-84 · Padagis →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.