Metronidazole 7.5 mg/g Gel
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Nitroimidazole Antimicrobial class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Metronidazole topical is used to treat rosacea (a skin disease that causes redness, flushing, and pimples on the face). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria.
Read the full MedlinePlus article ↗- This is one of the most important things to know about metronidazole. If you drink alcohol — or consume products containing propylene glycol — while taking it, you can have a prett...
- Why do I have to avoid alcohol while taking this?
- Yes, completely normal and actually really important. Trichomoniasis is a sexually transmitted infection, so even if your partner has no symptoms, they can still carry the parasite...
- My partner and I both have to take this for trichomoniasis — is that normal?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Metronidazole — tap one for details:
Metronidazole may be associated with lower levels of 7 nutrients — worth a chat with your pharmacist, not a cause for alarm.
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Where does this data come from?
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII 4Q93RCW27E
A synthetic polymer made from acrylic acid that's crosslinked for stability. It acts as a thickener and gelling agent in creams and gels, helping the medicine spread evenly and maintain its texture.
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UNII 7FLD91C86K
Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
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UNII A2I8C7HI9T
Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
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UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
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UNII Z8IX2SC1OH
Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
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UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
7 inactive ingredients listed in the exact product block matched to this NDC.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.221 | $9.94 / 45 g |
| Medicaid paysCMS SDUD · 12 mo | $0.6820 | $30.69 / 45 g |
| Medicare drug plans payPart D · Q2 2026 | $0.7576 | $34.09 / 45 g |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Metronidazole 7.5 mg/g 00713-0637-37 | Cosette | 1 tube | $0.221 | AB | Availability likely | — |
| Metronidazole 7.5 mg/g 21922-0070-06 | Encube | 1 tube | $0.221 | AB | Availability likely | — |
| Metronidazole 7.5 mg/gthis 51672-4116-06 | Sun | 1 tube | $0.221 | AB | Availability likely | — |
| Metronidazole 7.5 mg/g 72578-0209-04 | Viona | 1 tube | $0.221 | AB | Availability likely | — |
| Metronidazole 7.5 mg/g 00713-0633-37 | Cosette | 1 tube | $0.268 | AB | Availability likely | +22% |
| Metronidazole 7.5 mg/g 68308-0711-45 | Mayne | 1 tube | $0.268 | AB | Availability likely | +22% |
| Metronidazole 7.5 mg/g 00168-0323-46 | Fougera | 45 g | $0.268 | AB | Availability likely | +22% |
| Metronidazole 7.5 mg/g 59651-0770-46 | Aurobindo | 1 tube | $0.268 | AB | Availability likely | +22% |
| Metronidazole 7.5 mg/g 66993-0960-45 | Prasco | 1 tube | $0.268 | AB | Availability likely | +22% |
| Metronidazole 7.5 mg/g 72578-0129-08 | Viona | 1 tube | $0.268 | BX | Availability likely | +22% |
| metronidazole 7.5 mg/g 68308-0712-59 | Mayne | 1 bottle | $1.792 | AB | Availability likely | +711% |
| Metronidazole 7.5 mg/g 67296-2121-04 | Redpharm | 1 tube | — | AB | FDA listed | — |
| Metronidazole 7.5 mg/g 70771-1978-04 | Zydus | 1 tube | — | AB | FDA listed | — |
| Metronidazole 7.5 mg/g 70771-1834-04 | Zydus | 1 tube | — | BX | FDA listed | — |
| Metronidazole 7.5 mg/g 68788-8552-04 | Preferred | 1 tube | — | BX | FDA listed | — |
| Metronidazole 7.5 mg/g 72162-2259-02 | Bryant | 45 g | — | AB | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
🗺️ Medicaid utilization & spend
💊 Medicaid utilization by pack size
📊 Medicare Part D spend CMS · PART D · 2026 (Q1)
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Status |
|---|---|---|---|---|---|
| 51672-4116-02 | 1 TUBE in 1 CARTON (51672-4116-2) / 30 g in 1 TUBE | — | — | 2006-07-18 | Active |
| 51672-4116-05 | 5 g in 1 TUBE (51672-4116-5) | — | — | 2006-07-18 | Active |
| 51672-4116-06 You're viewing this | 1 TUBE in 1 CARTON (51672-4116-6) / 45 g in 1 TUBE | $0.2209 / g | $9.94 | 2006-07-18 | Active |
In Medicaid, this is the most-dispensed pack of this product — about 100% of fills over the last four reported quarters. See all packs ↓
Pack size FAQ
What quantity is in NDC 51672-4116-06?
What NDC number is used to bill for this package of Metronidazole 7.5 mg/g Gel?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
📄 Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATIONS AND USAGE Metronidazole gel is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION Apply and rub in a thin film of metronidazole gel twice daily, morning and evening, to entire affected areas after washing. Areas to be treated should be cleansed before application of metronidazole gel. Patients may use cosmetics after application of metronidazole gel.
⛔ Contraindications ▾
CONTRAINDICATIONS Metronidazole gel is contraindicated in individuals with a history of hypersensitivity to metronidazole, parabens, or other ingredients of the formulation.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS The following adverse experiences have been reported with the topical use of metronidazole: burning, skin irritation, dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.
🔄 Drug Interactions ▾
Drug interactions Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin time is not known.
🤰 Pregnancy ▾
Pregnancy Teratogenic effects Pregnancy category B There has been no experience to date with the use of metronidazole gel in pregnant patients. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice.
However, because animal reproduction studies are not always predictive of human response and since oral metronidazole has been shown to be a carcinogen in some rodents, this drug should be used during pregnancy only if clearly needed.
🧒 Pediatric Use ▾
Pediatric use Safety and effectiveness in pediatric patients have not been established.
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY Bioavailability studies on the topical administration of 1 gram of metronidazole gel (7.5 mg of metronidazole) to the face of 10 rosacea patients showed a maximum serum concentration of 66 nanograms per milliliter in one patient. This concentration is approximately 100 times less than concentrations afforded by a single 250 mg oral tablet. The serum metronidazole concentrations were below the detectable limits of the assay at the majority of time points in all patients.
Three of the patients had no detectable serum concentrations of metronidazole at any time point. The mean dose of gel applied during clinical studies was 600 mg which represents 4.5 mg of metronidazole per application. Therefore, under normal usage levels, the formulation affords minimal serum concentrations of metronidazole.
The mechanisms by which metronidazole gel acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED Metronidazole Gel USP, 0.75% is supplied in aluminum tubes containing: 5 g NDC 51672-4116-5 (physician sample, tube only) 30 g NDC 51672-4116-2 45 g NDC 51672-4116-6 Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].
📦 Storage and Handling ▾
Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].
📋 Description ▾
DESCRIPTION Metronidazole gel contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in a gel consisting of carbomer 940, edetate disodium, methylparaben, propylene glycol, propylparaben, purified water, and sodium hydroxide. Metronidazole is classified therapeutically as an antiprotozoal and antibacterial agent. Chemically, metronidazole is named 2-methyl-5-nitro-1 H -imidazole-1-ethanol and has the following structure: Chemical Structure
💬 Information for Patients ▾
Information for patients This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.