Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG... — RxCUI 1297288
RxNorm drug concept · Semantic clinical drug
RxCUI 1297288
Semantic clinical drug · SCD
● Current RxNorm concept 73 FDA products
88 package NDCs
Snapshot Jul 14, 2026
What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.
🗂️ Key Facts
RxCUI1297288
Official nameAcetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / Dextromethorphan Hydrobromide 10 MG / doxylamine succinate 6.25 MG / Phenylephrine Hydrochloride 5 MG Oral Capsule; acetaminophen 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine HCl 5 MG Oral Capsule
FDA products mapped73
Package NDCs mapped88
RxNorm release07/06/2026
Snapshot dataJul 14, 2026
📖 Skip the Codes — Read It in Plain English.
Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.
📗 Our plain-language guide HelloPharmacist
- Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
- I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
- You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
- Can I use the nasal spray if I have high blood pressure or heart disease?
🕸️ Concept Web — How Acetaminophen 325 MG / dextromethorphan hydrobro... Connects
One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept
Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule
RxCUI 1297288 Semantic clinical drug · SCD
Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.
-
Ingredients 8
The active substance itself — no strength, form, or brand attached yet.
-
Acetaminophen
161IN -
Dextromethorphan
3289IN -
Doxylamine
3642IN -
Phenylephrine
8163IN -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine
1008701MIN -
Dextromethorphan hydrobromide
102490PIN -
Doxylamine succinate
23665PIN -
Phenylephrine hydrochloride
8164PIN
-
Acetaminophen
-
Dose forms 9
The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
-
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Capsule
1297287SCDF -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Capsule
2646252SCDFP -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product
1155896SCDG -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Pill
1297772SCDG -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Product
2660518SCDGP -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Pill
2661266SCDGP -
Oral Capsule
316965DF -
Oral Product
1151131DFG - +1 more in this family
-
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Capsule
-
Clinical & branded drugs 4
Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
-
Acetaminophen 325 MG
315263SCDC -
Dextromethorphan hydrobromide 10 MG
1014455SCDC -
Doxylamine succinate 6.25 MG
1052646SCDC -
Phenylephrine hydrochloride 5 MG
1020198SCDC
-
Acetaminophen 325 MG
-
Packs 3
Fixed collections of drugs packaged and sold together, like dose packs.
-
{1 (acetaminophen 250 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
1927849GPCK -
{1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
2634364GPCK -
{1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
2634363GPCK
-
{1 (acetaminophen 250 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
Showing up to 8 concepts per family — 23 of 24 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.
🔀 Generic ⇄ Brand Crosswalk
The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.
Generic (Clinical) Concepts
-
{1 (acetaminophen 250 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
GPCK · 1927849 -
{1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
GPCK · 2634364 -
{1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule) / 1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule) } Pack
GPCK · 2634363 -
Acetaminophen 325 MG
SCDC · 315263 -
Dextromethorphan hydrobromide 10 MG
SCDC · 1014455 -
Doxylamine succinate 6.25 MG
SCDC · 1052646 -
Phenylephrine hydrochloride 5 MG
SCDC · 1020198 -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Capsule
SCDF · 1297287 -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Capsule
SCDFP · 2646252 -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product
SCDG · 1155896
📦 FDA Products & Package NDCs
73 products · 88 package NDCs
88 package NDCs map to RxCUI 1297288 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
| Package NDC | Package | Brand / generic name | Labeler | Marketing start |
|---|---|---|---|---|
| 00280-0035-01 | 1 KIT in 1 CARTON (0280-0035-01) * 3 CAPSULE, LIQUID FILLE... | Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax | Bayer HealthCare LLC. | 2020-06-01 |
| 00280-0040-01 | 1 KIT in 1 CARTON (0280-0040-01) * 12 CAPSULE, LIQUID FILL... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu | Bayer HealthCare LLC. | 2020-10-26 |
| 00280-0062-01 | 1 KIT in 1 CARTON (0280-0062-01) * 2 CAPSULE, LIQUID FILLE... | Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night | Bayer HealthCare, LLC. | 2020-06-01 |
| 00280-0097-01 | 2 BLISTER PACK in 1 CARTON (0280-0097-01) / 8 CAPSULE, LIQU... | Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels | Bayer HealthCare LLC. | 2021-08-25 |
| 00280-0097-02 | 2 BLISTER PACK in 1 CARTON (0280-0097-02) / 12 CAPSULE, LIQ... | Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels | Bayer HealthCare LLC. | 2021-08-25 |
| 00280-0098-01 | 1 KIT in 1 CARTON (0280-0098-01) * 2 CAPSULE in 1 BLISTER... | Alka-Seltzer Plus Cold Day and Night PowerMax gels | Bayer HealthCare LLC. | 2018-09-14 |
| 00280-0099-01 | 1 KIT in 1 CARTON (0280-0099-01) * 2 CAPSULE in 1 BLISTER... | Alka-Seltzer Plus Cold Day and Night PowerMax gels | Bayer HealthCare LLC. | 2018-09-14 |
| 00280-0125-01 | 1 KIT in 1 CARTON (0280-0125-01) * 4 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | 2018-07-02 |
| 00280-0506-20 | 1 KIT in 1 CARTON (0280-0506-20) * 2 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Severe Cough Mucus and Congestion Day and Night | Bayer HealthCare LLC. | 2017-05-30 |
| 00280-1580-20 | 1 KIT in 1 CARTON (0280-1580-20) * 2 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu | Bayer HealthCare LLC. | 2017-05-22 |
| 00280-1581-40 | 1 KIT in 1 CARTON (0280-1581-40) * 4 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu | Bayer HealthCare LLC. | 2017-05-22 |
| 00280-1600-20 | 2 BLISTER PACK in 1 CARTON (0280-1600-20) / 10 CAPSULE, LIQ... | Alka-Seltzer Plus Maximum Strength Night Cold and Flu | Bayer HealthCare LLC. | 2017-06-19 |
| 00280-1610-20 | 1 KIT in 1 CARTON (0280-1610-20) * 2 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and Night | Bayer HealthCare LLC. | 2017-06-12 |
| 00280-1620-20 | 2 BLISTER PACK in 1 CARTON (0280-1620-20) / 10 CAPSULE, LIQ... | Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough | Bayer HealthCare LLC. | 2017-06-26 |
| 00280-1640-16 | 2 BLISTER PACK in 1 CARTON (0280-1640-16) / 8 CAPSULE, LIQU... | Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | 2018-07-02 |
| 00280-1640-24 | 3 BLISTER PACK in 1 CARTON (0280-1640-24) / 8 CAPSULE, LIQU... | Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | 2018-07-02 |
| 00280-1650-16 | 1 KIT in 1 CARTON (0280-1650-16) * 2 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | 2018-07-02 |
| 00280-1680-24 | 1 KIT in 1 CARTON (0280-1680-24) * 2 BLISTER PACK in 1 CAR... | Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | 2018-07-02 |
| 00280-8276-16 | 2 BLISTER PACK in 1 CARTON (0280-8276-16) / 8 CAPSULE, LIQU... | ALKA SELTZER COLD Cold and Allergy Maximum Strength Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00280-8276-24 | 2 BLISTER PACK in 1 CARTON (0280-8276-24) / 12 CAPSULE, LIQ... | ALKA SELTZER COLD Cold and Allergy Maximum Strength Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00280-8282-24 | 3 BLISTER PACK in 1 CARTON (0280-8282-24) / 8 CAPSULE, LIQU... | ALKA SELTZER COLD Cold Flu and Congestion Severe Night Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00280-8283-24 | 1 KIT in 1 CARTON (0280-8283-24) * 1 CAPSULE, LIQUID FILLE... | ALKA SELTZER COLD Cold and Sinus Maximum Strength Day Night Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00280-8286-16 | 1 KIT in 1 CARTON (0280-8286-16) * 1 CAPSULE, LIQUID FILLE... | ALKA SELTZER COLD Cold Mucus and Congestion Maximum Strength Day Night Fast Gels | Bayer HealthCare, LLC. | 2026-06-01 |
| 00280-8286-24 | 1 KIT in 1 CARTON (0280-8286-24) * 1 CAPSULE, LIQUID FILLE... | ALKA SELTZER COLD Cold Mucus and Congestion Maximum Strength Day Night Fast Gels | Bayer HealthCare, LLC. | 2026-06-01 |
| 00280-8288-16 | 1 KIT in 1 CARTON (0280-8288-16) * 1 CAPSULE, LIQUID FILLE... | ALKA SELTZER COLD Cold Flu and Congestion Maximum Strength Day Night Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00280-8288-24 | 1 KIT in 1 CARTON (0280-8288-24) * 1 CAPSULE, LIQUID FILLE... | ALKA SELTZER COLD Cold Flu and Congestion Maximum Strength Day Night Fast Gels | Bayer HealthCare LLC. | 2026-06-01 |
| 00363-0744-24 | 3 BLISTER PACK in 1 CARTON (0363-0744-24) / 1 KIT in 1 BLIS... | Daytime Nighttime Sinus Relief Maximum Strength | Walgreens | 2022-06-01 |
| 00363-0746-24 | 3 BLISTER PACK in 1 CARTON (0363-0746-24) / 1 KIT in 1 BLIS... | DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength | Walgreens | 2022-06-01 |
| 00363-0746-48 | 6 BLISTER PACK in 1 CARTON (0363-0746-48) / 1 KIT in 1 BLIS... | DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength | Walgreens | 2022-06-01 |
| 00363-0775-24 | 3 BLISTER PACK in 1 CARTON (0363-0775-24) / 1 KIT in 1 BLIS... | Daytime and Nighttime Cold and Flu Maximum Strength | Walgreens | 2022-06-01 |
| 00363-1011-24 | 2 BLISTER PACK in 1 CARTON (0363-1011-24) / 12 CAPSULE, LIQ... | NIGHTTIME COLD AND FLU Maximum Strength | WALGREENS | 2022-06-23 |
| 00363-8995-24 | 1 KIT in 1 PACKAGE, COMBINATION (0363-8995-24) * 8 CAPSULE... | SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME | Walgreens | 2021-08-23 |
| 00363-8997-24 | 2 BLISTER PACK in 1 CARTON (0363-8997-24) / 12 CAPSULE, GEL... | SEVERE NIGHTTIME COLD AND FLU | WALGREENS | 2021-08-23 |
| 00363-9077-24 | 1 KIT in 1 PACKAGE (0363-9077-24) * 2 BLISTER PACK in 1 CA... | Walgreens Maximum Strength Non Drowsy Day and Night Cold and Flu | Walgreens | 2022-09-20 |
| 00363-9080-24 | 1 KIT in 1 PACKAGE (0363-9080-24) * 2 BLISTER PACK in 1 CA... | Walgreens Maximum Strength Non-Drowsy Day and Night Sinus and Cold | Walgreens | 2022-09-20 |
| 11673-0983-08 | 1 BLISTER PACK in 1 CARTON (11673-983-08) / 8 CAPSULE, LIQU... | COLD AND FLU NIGHTTIME SEVERE | TARGET CORP | 2020-06-01 |
| 11673-0983-24 | 2 BLISTER PACK in 1 CARTON (11673-983-24) / 12 CAPSULE, LIQ... | COLD AND FLU NIGHTTIME SEVERE | TARGET CORP | 2020-06-01 |
| 11673-0984-24 | 24 BLISTER PACK in 1 CARTON (11673-984-24) / 1 KIT in 1 BLI... | COLD AND FLU DAYTIME-NIGHTTIME | TARGET CORP | 2020-06-03 |
| 35916-0167-01 | 2 BLISTER PACK in 1 CARTON (35916-0167-1) / 12 CAPSULE, LIQ... | Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | SOFTGEL HEALTHCARE PRIVATE LIMITED | 2024-08-22 |
| 35916-0186-01 | 2 POUCH in 1 BOX (35916-0186-1) / 3000 CAPSULE, LIQUID FILL... | Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | Softgel Healthcare Pvt Ltd | 2025-06-11 |
| 35916-0186-02 | 2 POUCH in 1 BOX (35916-0186-2) / 2000 CAPSULE, LIQUID FILL... | Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | Softgel Healthcare Pvt Ltd | 2025-09-25 |
| 35916-0186-03 | 2 BAG in 1 BOX (35916-0186-3) / 1500 CAPSULE, LIQUID FILLED... | Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | Softgel Healthcare Pvt Ltd | 2026-01-12 |
| 37000-0518-02 | 2 CAPSULE, LIQUID FILLED in 1 POUCH (37000-518-02) | Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2021-01-01 |
| 37000-0518-08 | 1 BLISTER PACK in 1 CARTON (37000-518-08) / 8 CAPSULE, LIQU... | Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2019-07-01 |
| 37000-0518-24 | 2 BLISTER PACK in 1 CARTON (37000-518-24) / 12 CAPSULE, LIQ... | Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2018-07-10 |
| 37000-0934-12 | 1 KIT in 1 PACKAGE (37000-934-12) * 1 BLISTER PACK in 1 CA... | Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2019-07-04 |
| 37000-0934-24 | 1 KIT in 1 PACKAGE (37000-934-24) * 1 BLISTER PACK in 1 CA... | Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2019-07-04 |
| 37000-0934-48 | 1 KIT in 1 PACKAGE (37000-934-48) * 1 BLISTER PACK in 1 CA... | Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2019-07-04 |
| 37000-0934-72 | 1 KIT in 1 PACKAGE (37000-934-72) * 1 BLISTER PACK in 1 CA... | Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu | The Procter & Gamble Manufacturing Company | 2019-07-04 |
| 41226-0627-24 | 24 BLISTER PACK in 1 CARTON (41226-627-24) / 1 KIT in 1 BLI... | DAYTIME-NIGHTTIME SEVERE COLD AND FLU | KROGER | 2020-06-03 |
Observed labelers:
Bayer HealthCare LLC. (23) ·
Walgreens (9) ·
The Procter & Gamble Manufacturing Company (7) ·
Topco Associates LLC (6) ·
Reckitt Benckiser LLC (4) ·
Bayer HealthCare, LLC. (3)
· +18 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.
🗃️ Sources & Limits
Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
- A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
- Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
- Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
- Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.