Melphalan Hydrochloride Injection shortage
Melphalan Hydrochloride Injection is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Sep 18, 2026.
The FDA shortage report covers 1 product of Melphalan Hydrochloride Injection (being discontinued) — but other makers (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., Sagent Pharmaceuticals and others ) haven’t reported a shortage, so it may still be available.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Melphalan Hydrochloride Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Sep 16, 2026Currently in shortage1 of 1 product affected.
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Sep 16, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 1 NDC click to expand
| Status | NDC / product | Strength / size | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Melphalan Hydrochloride, Injection, Kit (NDC 63323-760-20) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Melphalan Hydrochloride Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Melphalan Hydrochloride Injection? options further down this page.
Why is Melphalan Hydrochloride Injection in shortage?
- Discontinuation of the manufacture of the drug
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Melphalan Hydrochloride Injection. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Melphalan Hydrochloride Injection?
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Melphalan Hydrochloride Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Melphalan Hydrochloride Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Melphalan Hydrochloride | Kit | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 23155-0355-41 | |
| Melphalan Hydrochloride | Kit · Intravenous | Sagent Pharmaceuticals | 25021-0258-61 | |
| Melphalan Hydrochloride | Kit · Intravenous | Dr.Reddy's Laboratories Inc | 43598-0392-48 | |
| Melphalan Hydrochloride | Kit | BPI Labs LLC | 54288-0109-02 | |
| Melphalan Hydrochloride | Kit | Mylan Institutional LLC | 67457-0195-01 | |
| Melphalan Hydrochloride | Kit · Intravenous | Meitheal Pharmaceuticals Inc. | 71288-0132-90 | |
| Melphalan Hydrochloride | Kit | Fosun Pharma USA Inc | 72266-0128-01 | |
| Hepzato Kit | Kit · Intra-Arterial | Delcath Systems, Inc. | 75833-0601-01 | |
| Melphalan Hydrochloride | Kit · Intravenous | Avenacy Inc. | 83634-0202-61 |
Alternative dosage forms of Melphalan Hydrochloride
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 16 productsclick to expand
Orange Book–rated equivalents of the affected strengths / sizes, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Melphalan hydrochloride | Heritage | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Sagent | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Camber | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Dr.Reddy's | 1 kit | — | AP | FDA listed |
| Melphalan hydrochloride | BPI | 1 kit | — | AP | FDA listed |
| Melphalan | Fresenius | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Qilu | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Mylan | 1 kit | — | AP | FDA listed |
| Melphalan hydrochloride | Gland | 1 kit | — | AP | FDA listed |
| Melphalan hydrochloride | Meitheal | 1 kit | — | AP | FDA listed |
| Melphalan hydrochloride | Fosun | 1 kit | — | AP | FDA listed |
| Evomela 50 mg/10mL | Acrotech | 1 vial | — | — | FDA listed |
| Hepzato Kit | Delcath | 1 kit | — | — | FDA listed |
| Melphalan Hydrochloride | Dr.Reddy's | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Avenacy | 1 kit | — | AP | FDA listed |
| Melphalan Hydrochloride | Arthur | 1 kit | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Melphalan Hydrochloride Injection — that fall in the same broad treatment class (antineoplastic - alkylating agents) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
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Melphalan Hydrochloride Injection shortage FAQs
Is Melphalan Hydrochloride Injection in shortage?
Which products are affected?
When will Melphalan Hydrochloride Injection be available again?
Can I still get Melphalan Hydrochloride somewhere?
What should I do if I take Melphalan Hydrochloride Injection?
Still have a question about the Melphalan Hydrochloride Injection shortage?
Ask a pharmacist about this shortage →View Melphalan Hydrochloride Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.