Amikacin

19 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Aspirin Rectal Cefepime Injection Cidofovir Injection Colistimethate Injection Emtricitabine
8 Major 5 Moderate 6 Minor
All (19) Major (8) Moderate (5) Minor (6)

Major

Amikacin Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Amikacin Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Amikacin Cefepime Injection Maxipime® An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Amikacin Cidofovir Injection Vistide® Nephrotoxicity Details Amikacin Colistimethate Injection Coly-Mycin M® Respiratory depression Details Amikacin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Amikacin Foscarnet Injection Foscavir Nephrotoxicity Details Amikacin Furosemide Injection Disal Increased amikacin exposure and an increased risk of ototoxicity and/or nephrotoxicity Details

Moderate

Amikacin Carboplatin Kyxata Ototoxicity Details Amikacin Carboplatin Injection Kyxata Ototoxicity Details Amikacin Cyclosporine Injection Atopica Renal dysfunction or nephrotoxicity Details Amikacin Cyclosporine Ophthalmic Cequa Renal dysfunction or nephrotoxicity Details Amikacin Ibuprofen Addaprin Increase amikacin exposure Details

Minor

Amikacin Amoxicillin Amoxi Drop Loss of aminoglycoside efficacy Details Amikacin Ampicillin Amcill® Loss of aminoglycoside efficacy Details Amikacin Ampicillin Injection Omnipen-N® Loss of aminoglycoside efficacy Details Amikacin Nafcillin Injection Unipen® Injection Loss of aminoglycoside efficacy Details Amikacin Penicillin G Procaine Injection Bactracillin G Loss of aminoglycoside efficacy Details Amikacin Penicillin V Potassium Beepen-VK® Loss of aminoglycoside efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.