Avapritinib

126 interactions 1 explained in plain English 259 cited references
Also sold as: Ayvakit Ayvakit®
About Avapritinib

Avapritinib is used to treat a certain type of gastrointestinal stromal tumor (GIST; a type of tumor that grows in the wall of the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in adults that has spread to other parts of the body or that cannot be removed by surgery. It is a… Read the full Avapritinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Levoketoconazole Ensitrelvir Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live
11 Contraindicated 108 Major 7 Moderate
All (126) Contraindicated (11) Major (108) Moderate (7)

Major

Avapritinib Elagolix Orilissa Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Avapritinib Enzalutamide Xtandi Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Erythromycin Erythrocin Stearate Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Ethinyl Estradiol Increased ethinyl estradiol exposure and an increased risk of ethinyl estradiol-related adverse reactions Details Avapritinib Etravirine Intelence Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Avapritinib Fexinidazole An increased CYP3A4 substrate exposure Details Avapritinib Fluconazole Diflucan Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Fosamprenavir Lexiva Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Fosnetupitant Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Fosphenytoin Cerebyx Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Idelalisib Zydelig Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Imatinib Gleevec Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Indinavir Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Avapritinib Isavuconazole Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Isavuconazonium Cresemba Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Itraconazole Sporanox Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Ivosidenib Tibsovo Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Ketoconazole Extina Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Larotrectinib Increased sensitive CYP3A4 substrate exposure and increase in the incidence or severity of adverse reactions Details Avapritinib Lefamulin Xenleta Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Lenacapavir Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Avapritinib Lesinurad Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Letermovir Prevymis Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Lonafarnib Zokinvy Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Avapritinib Lopinavir Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Lorlatinib Lorbrena Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Lumacaftor Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Mifepristone Korlym Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Mitapivat Aqvesme Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Mitotane Lysodren Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Modafinil Provigil Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Nafcillin Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Nefazodone Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Nelfinavir Viracept Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Netupitant Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Nilotinib Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Nirogacestat Ogsiveo Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details

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