Baclofen

23 interactions 3 explained in plain English
Also sold as: Fleqsuvy Gablofen Lioresal Lyvispah Ozobax
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Hydroxychloroquine Butorphanol Injection Butorphanol Nasal Spray Morphine Injection Nalbuphine Injection
21 Major 1 Moderate 1 Minor
All (23) Major (21) Moderate (1) Minor (1)

Major

Baclofen Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of profound sedation, respiratory depression, coma and death Details Baclofen Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Baclofen Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Baclofen Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Baclofen Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Baclofen Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Baclofen Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Baclofen Diazepam Rectal Diastat Increased risk of CNS depression Details Baclofen Esketamine Nasal Spray Spravato Increased risk of sedation Details Baclofen Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Baclofen Hydromorphone Injection Dilaudid Increased risk of profound sedation, respiratory depression, coma and death Details Baclofen Hydromorphone Rectal available generically Increased risk of profound sedation, respiratory depression, coma and death Details Baclofen Hydroxychloroquine Plaquenil An increased risk of seizures Details Baclofen Lacosamide Injection Motpoly An increased risk of CNS depression Details Baclofen Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Baclofen Metoclopramide Injection Gimoti Increased risk of CNS depression Details Baclofen Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Baclofen Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Baclofen Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Baclofen Morphine Injection Astramorph® PF Increased risk of profound sedation, hypotension, coma and respiratory depression Details Baclofen Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Baclofen Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

Minor

Baclofen Amitriptyline Elavil Explained Memory loss, loss of muscle tone Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.