Cimetidine

83 interactions 6 explained in plain English
Also sold as: Tagamet
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Cimetidine Amitriptyline Elavil Explained Amitriptyline toxicity (dry mouth, blurred vision, urinary retention) Details Cimetidine Sertraline Explained Elevated sertraline serum concentrations and increased risk of adverse side effects Details Cimetidine Azelastine Nasal Spray Astelin® Nasal Spray An increased risk of azelastine adverse effects (increased somnolence, headache, bitter taste) Details Cimetidine Azelastine Ophthalmic Optivar® An increased risk of azelastine adverse effects (increased somnolence, headache, bitter taste) Details Cimetidine Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Cimetidine Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Cimetidine Dutasteride Avodart Increase in dutasteride plasma concentrations Details Cimetidine Epirubicin Ellence An increased risk of epirubicin toxicity (myelosuppression, cardiotoxicity) Details Cimetidine Flecainide Tambocor® Elevated flecainide serum levels and increased risk of flecainide toxicity (cardiac arrhythmias, neurologic effects, exacerbation... Details Cimetidine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Cimetidine Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Cimetidine Glipizide Glucotrol Hypoglycemia Details Cimetidine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cimetidine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cimetidine Labetalol Normodyne® Increased labetalol serum levels, bradycardia, and hypotension Details Cimetidine Memantine Namenda Altered plasma levels of memantine and cimetidine Details Cimetidine Midazolam Nasal Spray Nayzilam Midazolam toxicity (CNS depression, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance) Details Cimetidine Midazolam Injection Nayzilam Midazolam toxicity (CNS depression, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance) Details Cimetidine Nebivolol Bystolic Increased nebivolol plasma levels Details Cimetidine Nicardipine Cardene An increase in plasma concentrations of niCARdipine Details Cimetidine Nimodipine Nimotop Increased nimodipine serum levels Details Cimetidine Nisoldipine Sular Increased bioavailability of nisoldipine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.