Dolasetron

332 interactions 1 explained in plain English 421 cited references

Also sold as: Anzemet Anzemet®

About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Phenelzine Saquinavir Pimozide Mesoridazine Sparfloxacin

16 Contraindicated 314 Major 1 Moderate 1 Minor

All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Major

Dolasetron Lidoflazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Linezolid Zyvox Increased risk of serotonin syndrome Details Dolasetron Lisdexamfetamine Arynta An increased risk of serotonin syndrome Details Dolasetron Lithium Increased risk of serotonin syndrome Details Dolasetron Lofepramine Increased risk of serotonin syndrome Details Dolasetron Lofexidine Increased risk of QT interval prolongation Details Dolasetron Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Dolasetron Lopinavir An increased risk of QT interval prolongation Details Dolasetron Lorcainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Lorcaserin Increased risk of serotonin syndrome Details Dolasetron Lumefantrine An increased risk of QT interval prolongation Details Dolasetron Macimorelin Increased risk of QT interval prolongation Details Dolasetron Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Melitracen Increased risk of serotonin syndrome Details Dolasetron Meperidine Demerol Increased risk of serotonin syndrome Details Dolasetron Metaxalone Skelaxin Increased risk of serotonin syndrome Details Dolasetron Methadone Diskets Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Methamphetamine Desoxyn An increased risk of serotonin syndrome Details Dolasetron Methylene Blue Provayblue Increased risk of serotonin syndrome Details Dolasetron Metronidazole Flagyl An increased risk of QT interval prolongation Details Dolasetron Mifepristone Korlym An increased risk of QT interval prolongation Details Dolasetron Milnacipran Savella Increased risk of serotonin syndrome Details Dolasetron Milsaperidone An increased risk of QT interval prolongation Details Dolasetron Mirtazapine Mirataz Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Dolasetron Mobocertinib Exkivity An increased risk of QT interval prolongation Details Dolasetron Moclobemide Increased risk of serotonin syndrome Details Dolasetron Morphine Increased risk of serotonin syndrome Details Dolasetron Morphine Sulfate Liposome Increased risk of serotonin syndrome Details Dolasetron Moxifloxacin Avelox Increased risk of QT interval prolongation Details Dolasetron Nalbuphine Increased risk of serotonin syndrome Details Dolasetron Naratriptan Increased risk of serotonin syndrome Details Dolasetron Nefazodone Increased risk of serotonin syndrome Details Dolasetron Nelfinavir Viracept Increased risk of QT interval prolongation Details Dolasetron Nilotinib An increased risk of QT interval prolongation Details Dolasetron Norfloxacin An increased risk of QT interval prolongation Details Dolasetron Nortriptyline Increased risk of serotonin syndrome Details Dolasetron Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Ofloxacin Floxin® An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.