Loperamide

429 interactions 426 cited references

Also sold as: Diamode Imodium Imodium® Imodium® AD Imotil® K-Pek II® Kao-Paverin® Kaopectate 1-D® Maalox® Anti-Diarrheal Pepto® Diarrhea Control

About Loperamide

Loperamide is an antidiarrheal medication used to control acute diarrhea and reduce bowel movements. Read the full Loperamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Mesoridazine Levoketoconazole Posaconazole Ketoconazole Piperaquine

16 Contraindicated 406 Major 7 Moderate

All (429) Contraindicated (16) Major (406) Moderate (7)

Major

Loperamide Lomitapide Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Lonafarnib Zokinvy Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Lumateperone Caplyta Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Lumefantrine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Lurasidone Latuda Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Macimorelin An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Maribavir Livtencity An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Mavorixafor Xolremdi An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Loperamide Medroxyprogesterone Amen® Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Mefloquine Lariam® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Mestranol Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Methadone Diskets An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Methotrimeprazine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Metronidazole Flagyl An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Mibefradil Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Midostaurin Rydapt Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Mifepristone Korlym An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Loperamide Milk Thistle Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Milsaperidone An increased risk of QT interval prolongation Details Loperamide Mirabegron Myrbetriq Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Mirtazapine Mirataz An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Mizolastine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Mobocertinib Exkivity An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Moricizine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Moxifloxacin Avelox An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Nafarelin An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Nefazodone An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Nelfinavir Viracept An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Loperamide Neratinib Nerlynx Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Netupitant Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Nifedipine Adalat® Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Nilotinib Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Nirmatrelvir Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Nirogacestat Ogsiveo Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Nomegestrol Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Norelgestromin Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Norethindrone Aygestin Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Norfloxacin An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Norgestimate Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Norgestrel Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details

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