Loperamide

429 interactions 426 cited references

Also sold as: Diamode Imodium Imodium® Imodium® AD Imotil® K-Pek II® Kao-Paverin® Kaopectate 1-D® Maalox® Anti-Diarrheal Pepto® Diarrhea Control

About Loperamide

Loperamide is an antidiarrheal medication used to control acute diarrhea and reduce bowel movements. Read the full Loperamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Mesoridazine Levoketoconazole Posaconazole Ketoconazole Piperaquine

16 Contraindicated 406 Major 7 Moderate

All (429) Contraindicated (16) Major (406) Moderate (7)

Major

Loperamide Octreotide Bynfezia An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Ofloxacin Floxin® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Olanzapine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Olaparib Lynparza Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Loperamide Omaveloxolone Skyclarys Reduced CYP3A4/CYP2C8 substrate exposure and reduced efficacy of CYP3A4/CYP2C8 substrate Details Loperamide Ondansetron An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Osilodrostat Isturisa Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Osimertinib Tagrisso Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Oxaliplatin An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Palbociclib Ibrance Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Paliperidone Erzofri An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Panobinostat Farydak An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Papaverine Pavacot® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Paritaprevir Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Paroxetine Paxil Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Pasireotide Signifor An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Pazopanib Votrient Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Pentamidine NebuPent An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Peppermint Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Perphenazine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Pexidartinib Turalio Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Pibrentasvir An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Pimavanserin Nuplazid An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Pipamperone An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Piperine An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Pirtobrutinib Jaypirca An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Pitolisant Wakix An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Ponesimod Ponvory An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Probucol An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Procainamide Procan® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Prochlorperazine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Promethazine Phenadoz An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Propafenone Rythmol Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Propofol Diprivan Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Protriptyline An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Quercetin Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Quetiapine Seroquel An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Quinidine Cardioquin® Increased loperamide exposure, an increased risk of loperamide-related adverse reactions, an increased risk of QT interval prolong... Details Loperamide Quinine Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details

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