Lurasidone and Voriconazole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Voriconazole
Lurasidone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased lurasidone exposure and an increased voriconazole exposure
Interaction Deep Dive
Concomitant use of lurasidone and voriconazole (strong CYP3A4 inhibitor) is contraindicated as coadministration may increase lurasidone exposure1 and the potential for serious or life-threatening reactions 234. Concomitant use of voriconazole and lurasidone (CYP3A4 inhibitor) may also increase the exposure of voriconazole. Reduce dosage of these drugs and monitor for adverse reactions 5.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of lurasidone; inhibition of CYP3A4-mediated metabolism of voriconazole
Literature reports
2 reports — tap to read
a) Coadministration of a single dose of lurasidone 10 mg with ketoconazole 400 mg/day at steady state (for 5 days) resulted in an increase in lurasidone Cmax and AUC by 6.9 and 9 times the levels relative to lurasidone administration alone, respectively 1.
b) Concurrent administration of oral voriconazole (400 mg every 12 hours for 1 day, then 200 mg every 12 hours for 2.5 days) and oral fluconazole (CYP3A4 inhibitor) (400 mg on day 1, then 200 mg every 24 hours for 4 days) to 6 healthy male subjects resulted in an increase in Cmax and AUC(tau) of voriconazole by an average of 57% (90% CI: 20%, 107%) and 79% (90% CI: 40%, 128%), respectively 5.
Common questions
Can I take Lurasidone and Voriconazole together?
Increased lurasidone exposure and an increased voriconazole exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lurasidone and Voriconazole interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Lurasidone or Voriconazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (5)
- Product Information: LATUDA(R) oral tablets, lurasidone HCl oral tablets. Sunovion Pharmaceuticals Inc (per FDA), Marlborough, MA, 2019. DailyMed
- Product Information: NORVIR(R) oral tablets, oral solution, ritonavir oral tablets, oral solution. AbbVie Inc. (per manufacturer), North Chicago, IL, 2016. DailyMed
- Product Information: NORVIR(R) oral capsules, ritonavir oral capsules. AbbVie Inc (per manufacturer), North Chicago, IL, 2016. DailyMed
- Product Information: KALETRA(R) oral tablets, oral solution, lopinavir ritonavir oral tablets, oral solution. AbbVie Inc (per FDA), North Chicago, IL, 2019. DailyMed
- Product Information: VFEND(R) oral tablets, oral suspension, intravenous injection, voriconazole oral tablets, oral suspension, intravenous injection. Roerig (per FDA), New York, NY, 2025. DailyMed
Keep reading about Voriconazole
Keep reading about Lurasidone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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