Nalbuphine

36 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nalbuphine Acetaminophen And Codeine Capital® & Codeine Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Nalbuphine Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Nalbuphine Sertraline Explained Increased risk of serotonin syndrome Details Nalbuphine Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Nalbuphine Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Nalbuphine Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Nalbuphine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Nalbuphine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Nalbuphine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Nalbuphine Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Nalbuphine Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Nalbuphine Diphenhydramine Injection Banophen Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details Nalbuphine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details Nalbuphine Dolasetron Anzemet Increased risk of serotonin syndrome Details Nalbuphine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Nalbuphine Esketamine Nasal Spray Spravato Increased risk of sedation Details Nalbuphine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Nalbuphine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Nalbuphine Hydromorphone Injection Dilaudid Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Nalbuphine Hydromorphone Rectal available generically Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Nalbuphine Hydroxychloroquine Plaquenil An increased risk of seizures Details Nalbuphine Lacosamide Injection Motpoly An increased risk of CNS depression Details Nalbuphine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Nalbuphine Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Nalbuphine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Nalbuphine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Nalbuphine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Nalbuphine Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Nalbuphine Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details Nalbuphine Morphine Injection Astramorph® PF Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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