Nalidixic Acid

Name: Nalidixic Acid Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Disopyramide Hydroxychloroquine

2 Major 6 Moderate

All (8) Major (2) Moderate (6)

Major

Nalidixic Acid Disopyramide Norpace Increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nalidixic Acid Hydroxychloroquine Plaquenil An increased risk of seizures Details

Moderate

Nalidixic Acid Cyclosporine Injection Atopica Increased cycloSPORINE serum concentrations and risk of toxicity Details Nalidixic Acid Cyclosporine Ophthalmic Cequa Increased cycloSPORINE serum concentrations and risk of toxicity Details Nalidixic Acid Didanosine Videx® Decreased nalidixic acid serum concentrations by buffered didanosine preparations Details Nalidixic Acid Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details Nalidixic Acid Melphalan Alkeran An increased risk of hemorrhagic necrotic enterocolitis Details Nalidixic Acid Melphalan Injection Alkeran An increased risk of hemorrhagic necrotic enterocolitis Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.