Norethindrone

53 interactions 3 explained in plain English

Also sold as: Aygestin Gallifrey

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Penicillin G Procaine Injection Colesevelam Cefprozil Meropenem Injection Bexarotene Topical

41 Major 12 Moderate

All (53) Major (41) Moderate (12)

Major

Norethindrone Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Norethindrone Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Norethindrone Ampicillin Amcill® Decreased contraceptive effectiveness Details Norethindrone Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Norethindrone Bexarotene Targretin Decreased contraceptive effectiveness Details Norethindrone Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Norethindrone Cefaclor Ceclor® Decreased contraceptive effectiveness Details Norethindrone Cefadroxil Duricef® Decreased contraceptive effectiveness Details Norethindrone Cefdinir Omnicef® Decreased contraceptive effectiveness Details Norethindrone Cefixime Suprax Decreased contraceptive effectiveness Details Norethindrone Cefprozil Cefzil® Decreased contraceptive effectiveness Details Norethindrone Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Norethindrone Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Norethindrone Colesevelam Welchol Decreased contraceptive effectiveness Details Norethindrone Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norethindrone Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norethindrone Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norethindrone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norethindrone Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Norethindrone Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Norethindrone Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Norethindrone Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Norethindrone Felbamate Felbatol Reduced norethindrone exposure, reduced efficacy of norethindrone and an increased risk of breakthrough bleeding/contraceptive fai... Details Norethindrone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Norethindrone Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norethindrone Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norethindrone Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Norethindrone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Norethindrone Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norethindrone Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norethindrone Methylergonovine Methergine Increased methylergonovine exposure Details Norethindrone Minocycline Amzeeq Decreased contraceptive efficacy Details Norethindrone Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Norethindrone Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Norethindrone Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Norethindrone Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Norethindrone Nifedipine Adalat® Increased NIFEdipine exposure Details Norethindrone Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norethindrone Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norethindrone Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.