Rifapentine

92 interactions 6 explained in plain English
Also sold as: Priftin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Rifapentine Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Rifapentine Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Rifapentine Alpelisib Piqray Reduced alpelisib exposure and reduced efficacy of alpelisib Details Rifapentine Apixaban Eliquis Explained Reduced apixaban exposure Details Rifapentine Apremilast Otezla Reduced apremilast exposure and an reduced efficacy of apremilast Details Rifapentine Aripiprazole Injection Abilify Reduced ARIPiprazole exposure Details Rifapentine Asciminib Scemblix Reduced asciminib exposure and reduced efficacy of asciminib Details Rifapentine Atogepant Qulipta Reduced atogepant exposure Details Rifapentine Belumosudil Rezurock Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Rifapentine Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Rifapentine Abiraterone Abirtega Reduced abiraterone exposure and reduced efficacy of abiraterone Details Rifapentine Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Rifapentine Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Rifapentine Bosutinib Bosulif Reduced bosutinib exposure and reduced efficacy of bosutinib Details Rifapentine Brexpiprazole Rexulti Reduced brexpiprazole exposure Details Rifapentine Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifapentine Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifapentine Cyclosporine Injection Atopica Reduced cycloSPORINE exposure and reduced cycloSPORINE efficacy Details Rifapentine Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure and reduced cycloSPORINE efficacy Details Rifapentine Dasatinib Phyrago Reduced dasatinib exposure and reduced efficacy of dasatinib Details Rifapentine Docetaxel Beizray Reduced docetaxel exposure Details Rifapentine Docetaxel Injection Beizray Reduced docetaxel exposure Details Rifapentine Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Rifapentine Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Rifapentine Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Rifapentine Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Rifapentine Erdafitinib Balversa Reduced erdafitinib exposure Details Rifapentine Erlotinib Tarceva Decreased erlotinib exposure and potential loss of efficacy Details Rifapentine Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifapentine Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifapentine Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifapentine Everolimus Afinitor Reduced everolimus exposure and reduced efficacy of everolimus Details Rifapentine Exemestane Aromasin Reduced exemestane exposure Details

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