Triflupromazine
30 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Nasal Spray
Metoclopramide Injection
Octreotide Injection
Hydromorphone Rectal
Butorphanol Injection
Butorphanol Nasal Spray
Contraindicated
Triflupromazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Triflupromazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Triflupromazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Triflupromazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Triflupromazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Triflupromazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Triflupromazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Triflupromazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Triflupromazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Triflupromazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Triflupromazine Diazepam Rectal Diastat Increased risk of CNS depression Details Triflupromazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Triflupromazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Triflupromazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Triflupromazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Triflupromazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Triflupromazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Triflupromazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Triflupromazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Triflupromazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Triflupromazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Triflupromazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) DetailsModerate
Triflupromazine Atenolol Tenormin Explained Hypotension and/or phenothiazine toxicity Details Triflupromazine Clonidine Transdermal Patch Catapres Induction or exacerbation of orthostatic regulation disturbances and an increased risk of sedation and somnolence Details Triflupromazine Diphenhydramine Injection Banophen Anticholinergic effects (dry mouth, urinary retention, altered mental status) Details Triflupromazine Diphenhydramine Topical Afterbite with Antihistamine Anticholinergic effects (dry mouth, urinary retention, altered mental status) Details Triflupromazine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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