Triflupromazine

30 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Triflupromazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Triflupromazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Triflupromazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Triflupromazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Triflupromazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Triflupromazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Triflupromazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Triflupromazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Triflupromazine Diazepam Rectal Diastat Increased risk of CNS depression Details Triflupromazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Triflupromazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Triflupromazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Triflupromazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Triflupromazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Triflupromazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Triflupromazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Triflupromazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Triflupromazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Triflupromazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Triflupromazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Triflupromazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.