Zafirlukast

13 interactions
Also sold as: Accolate Accolate®
About Zafirlukast

Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways. Read the full Zafirlukast drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Capecitabine Fluorouracil Fluorouracil Injection Fluorouracil Topical Meloxicam
10 Major 3 Minor
All (13) Major (10) Minor (3)

Major

Zafirlukast Azathioprine Azasan An increased risk of hepatotoxicity Details Zafirlukast Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Zafirlukast Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Zafirlukast Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Zafirlukast Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Zafirlukast Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Zafirlukast Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Zafirlukast Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Zafirlukast Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Zafirlukast Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Minor

Zafirlukast Aspirin Acuprin® An increased risk of zafirlukast adverse effects Details Zafirlukast Aspirin Rectal Aspirin An increased risk of zafirlukast adverse effects Details Zafirlukast Dofetilide Tikosyn Increased plasma concentration of dofetilide Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.