Drug & supplement interaction

Acai + Insulin Aspart, Insulin Degludec

Insulin Aspart, Insulin Degludec brand name: Ryzodeg 70/30.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Acai has a moderate interaction with Insulin Aspart, Insulin Degludec. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Acai and Insulin Aspart, Insulin Degludec

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Aspart, Insulin Degludec

Insulin Aspart, Insulin Degludec falls under ANTIDIABETES DRUGS — the group Acai interacts with.

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing acai with Ryzodeg (which combines fast-acting insulin aspart and long-acting insulin degludec): the concern is mostly theoretical. Some early research in healthy people suggests acai might nudge fasting blood sugar in either direction, up or down. We don't have solid data showing it meaningfully changes how insulin works.

Because insulin already lowers your blood sugar, the worry is that a concentrated acai supplement could add an unpredictable shift on top of that. If your sugar dropped too low, you might feel shaky, sweaty, dizzy, or confused. Enjoying acai as a food (like in a smoothie bowl) is generally not a concern. If you want to take acai supplements regularly, check in with your pharmacist or doctor first and keep monitoring your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Acai Also Interacts With Other Medications

Acai has 85 moderate known drug interactions in our database — the Insulin Aspart, Insulin Degludec one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Insulin Aspart, Insulin Degludec)
Taking anything else?

Check Another of Your Medications Against Acai

Covers the 2,830 medications we’ve checked against Acai. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Aspart, Insulin Degludec

This page covers Acai only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Aspart, Insulin Degludec page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), African Wild Potato (moderate), Agaricus Mushroom (moderate), Agmatine (moderate) and Agrimony (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Aspart, Insulin Degludec page

“Siberian cocklebur belongs at the top of any warning for people using Ryzodeg 70/30 (insulin aspart with insulin degludec). It has caused severe low blood sugar in humans, it is the one major-rated entry among the 239 ingredients on this page, and the documentation is strong enough that the safest course is simply not to take it.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Aspart, Insulin Degludec interaction page

One more smart check

Taking Acai as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,313 real supplement products containing Acai, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Acai. Your product may carry other ingredients that interact with Insulin Aspart, Insulin Degludec too, on top of Acai — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Acai and Insulin Aspart, Insulin Degludec Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acai
Top 10%

#98 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Aspart, Insulin Degludec
Top 5%

#124 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Acai

What is Acai?

Acai
  • Antioxidant support
  • Weight loss
  • Energy and vitality
  • Heart health
  • General wellness ('superfood')

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often attached to acai supplements, including weight loss and disease prevention.

Read the full Acai monograph & all interactions
Keep checking

Other Drugs & Acai

Browse every other medication we’ve checked against Acai — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Acai page.

No interaction 2,744 drugs checked — show the list

We also checked Acai against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Acai list.

See the full Acai interactions page
See every supplement checked against Insulin Aspart, Insulin Degludec, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Acai monograph › Uses, safety, and every drug interaction in one place Insulin Aspart, Insulin Degludec supplement interactions › Every supplement checked against Insulin Aspart, Insulin Degludec, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Acai and Insulin Aspart, Insulin Degludec Together: Common Questions

Can you take Acai with Insulin Aspart, Insulin Degludec?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Acai and Insulin Aspart, Insulin Degludec interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Aspart, Insulin Degludec and Acai?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.