Medication interaction hub

What Supplements Interact with Insulin Aspart, Insulin Degludec?

Insulin Aspart, Insulin Degludec brand name: Ryzodeg 70/30. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Aspart, Insulin Degludec? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Aspart, Insulin Degludec against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Siberian cocklebur belongs at the top of any warning for people using Ryzodeg 70/30 (insulin aspart with insulin degludec). It has caused severe low blood sugar in humans, it is the one major-rated entry among the 239 ingredients on this page, and the documentation is strong enough that the safest course is simply not to take it. The rest of the list earns genuine vigilance too, because every ingredient here can move your blood sugar one way or the other.

Most of the 208 moderate entries, ginseng among the more familiar, add to insulin's glucose-lowering effect and can tip you into a low. A smaller cluster works the opposite way; niacin, for instance, raises blood glucose and can blunt your doses, and alcohol-containing products can pull in both directions at once. The 30 minor entries echo the same themes at lower stakes. Whichever way a supplement pushes, your meter will notice before your symptoms do.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin Aspart, Insulin Degludec: Top Interactions at a Glance

The Insulin Aspart, Insulin Degludec supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin Aspart, Insulin Degludec Combinations Today

The Insulin Aspart, Insulin Degludec + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Milk Thistle + Insulin Aspart, Insulin Degludeci

Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Docosahexaenoic Acid (dha) + Insulin Aspart, Insulin Degludeci

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Insulin Aspart, Insulin Degludeci

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Galbanum + Insulin Aspart, Insulin Degludeci

Theoretically, taking galbanum with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Insulin Aspart, Insulin Degludeci

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Moderate Likelihood Probable American Ginseng + Insulin Aspart, Insulin Degludeci

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Aspart, Insulin Degludec

All 1,452 ingredients in our database, ranked by severity — 239 with a Insulin Aspart, Insulin Degludec interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Aspart, Insulin Degludec?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Milk Thistle with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Insulin Aspart, Insulin Degludec answer

Can you take Docosahexaenoic Acid (dha) with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.

Full Docosahexaenoic Acid (dha) + Insulin Aspart, Insulin Degludec answer

Can you take Eucalyptus with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.

Full Eucalyptus + Insulin Aspart, Insulin Degludec answer

Can you take Galbanum with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking galbanum with antidiabetes drugs might increase the risk of hypoglycemia.

Full Galbanum + Insulin Aspart, Insulin Degludec answer

Can you take Inulin with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.

Full Inulin + Insulin Aspart, Insulin Degludec answer

Can you take Kudzu with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Full Kudzu + Insulin Aspart, Insulin Degludec answer

Can you take Mommy's Bliss Gripe Water with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains ginger.

Full Mommy's Bliss Gripe Water + Insulin Aspart, Insulin Degludec answer

Can you take Oolong Tea with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.

Full Oolong Tea + Insulin Aspart, Insulin Degludec answer

Can you take Pu-erh Tea with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking pu-erh tea with antidiabetes drugs might interfere with blood glucose control.

Full Pu-erh Tea + Insulin Aspart, Insulin Degludec answer

Can you take Yerba Mate with Insulin Aspart, Insulin Degludec?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking yerba mate with antidiabetes drugs might interfere with blood glucose control.

Full Yerba Mate + Insulin Aspart, Insulin Degludec answer

Can you take Siberian Cocklebur with Insulin Aspart, Insulin Degludec?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Full Siberian Cocklebur + Insulin Aspart, Insulin Degludec answer

Can you take American Ginseng with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full American Ginseng + Insulin Aspart, Insulin Degludec answer

Can you take Astragalus with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Astragalus + Insulin Aspart, Insulin Degludec answer

Can you take Banaba with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Insulin Aspart, Insulin Degludec answer

Can you take Beer with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Beer + Insulin Aspart, Insulin Degludec answer

Can you take Bitter Melon with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Insulin Aspart, Insulin Degludec answer

Can you take Branched-chain Amino Acids (bcaa) with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BCAAs might alter the effects of antidiabetes medications.

Full Branched-chain Amino Acids (bcaa) + Insulin Aspart, Insulin Degludec answer

Can you take Cumin with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Insulin Aspart, Insulin Degludec answer

Can you take Ephedra with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Insulin Aspart, Insulin Degludec answer

Can you take Fenugreek with Insulin Aspart, Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Full Fenugreek + Insulin Aspart, Insulin Degludec answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Aspart, Insulin Degludec is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Aspart, Insulin Degludec, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Aspart, Insulin Degludec sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Aspart, Insulin Degludec through this category.

Related: does Insulin Aspart, Insulin Degludec deplete any nutrients?

Insulin Aspart, Insulin Degludec has 1 reported nutrient association in the research literature — see the Insulin Aspart, Insulin Degludec nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Aspart, Insulin Degludec

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Aspart, Insulin Degludec.

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Pharmacist Counseling Corner

Insulin Aspart, Insulin Degludec & Supplements: Common Questions

What supplements interact with Insulin Aspart, Insulin Degludec?
More than you might expect — 239 in total, though they are far from equal: 1 are rated major, 208 moderate, and 30 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Insulin Aspart, Insulin Degludec supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Aspart, Insulin Degludec?
Usually yes — most people on Insulin Aspart, Insulin Degludec can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ryzodeg 70/30 have the same supplement interactions as Insulin Aspart, Insulin Degludec?
Yes — Ryzodeg 70/30 all contain Insulin Aspart, Insulin Degludec, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Aspart, Insulin Degludec deplete any vitamins or nutrients?
It might — Insulin Aspart, Insulin Degludec has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Aspart, Insulin Degludec nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Aspart, Insulin Degludec and my other medications?
This page covers Insulin Aspart, Insulin Degludec against supplements and herbal ingredients. Checking Insulin Aspart, Insulin Degludec against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.