Drug & supplement interaction

Clove + Insulin Aspart, Insulin Degludec

Insulin Aspart, Insulin Degludec brand name: Ryzodeg 70/30.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Clove has a moderate interaction with Insulin Aspart, Insulin Degludec. Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Clove and Insulin Aspart, Insulin Degludec

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Aspart, Insulin Degludec

Insulin Aspart, Insulin Degludec falls under ANTIDIABETES DRUGS — the group Clove interacts with.

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Ryzodeg (insulin aspart and insulin degludec). This combo already lowers your blood sugar, and concentrated clove extracts may nudge it down a little further. If both push in the same direction, you could end up with low blood sugar (hypoglycemia), which can show up as shakiness, sweating, a racing heart, dizziness, confusion, or feeling suddenly very hungry.

I want to keep this in perspective. This is a theoretical concern based on how clove behaves in lab and early research, not something proven in people. The clove in your cooking won't matter here. The caution is really for concentrated clove oil or supplement doses. If you want to add those, check your blood sugar more closely at first and chat with your pharmacist or doctor before changing any insulin dose.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mohan R, Jose S, Mulakkal J, Karpinsky-Semper D, Swick AG, Krishnakumar IM. Water-soluble polyphenol-rich clove extract lowers pre- and post-prandial blood glucose levels in healthy and prediabetic volunteers: an open label pilot study. BMC Complement Alt PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Clove Also Interacts With Other Medications

Clove has 918 moderate, 60 minor known drug interactions in our database — the Insulin Aspart, Insulin Degludec one above is one of them. If you take anything else, check it against the full list below.

Moderate 918 Minor 60 No known interaction 1,852 (incl. Insulin Aspart, Insulin Degludec)
Taking anything else?

Check Another of Your Medications Against Clove

Covers the 2,830 medications we’ve checked against Clove. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Aspart, Insulin Degludec

This page covers Clove only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Aspart, Insulin Degludec page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Aspart, Insulin Degludec page

“Siberian cocklebur belongs at the top of any warning for people using Ryzodeg 70/30 (insulin aspart with insulin degludec). It has caused severe low blood sugar in humans, it is the one major-rated entry among the 239 ingredients on this page, and the documentation is strong enough that the safest course is simply not to take it.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Aspart, Insulin Degludec interaction page

One more smart check

Taking Clove as Part of a Dietary Supplement Product? Check It for Interactions

We hold 59 real supplement products containing Clove, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clove. Your product may carry other ingredients that interact with Insulin Aspart, Insulin Degludec too, on top of Clove — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clove and Insulin Aspart, Insulin Degludec Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clove
Top 25%

#159 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Aspart, Insulin Degludec
Top 5%

#75 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Clove

What is Clove?

Clove
  • Toothache and oral pain
  • Digestive upset
  • Antimicrobial and antifungal
  • Cough and respiratory complaints
  • Flavoring in food and drinks

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are generally safe, but concentrated clove oil and supplements can be irritating or toxic if overused, and human evidence for most health claims is limited. Talk to your pharmacist or doctor before using clove medicinally, especially in children or during pregnancy.

Read the full Clove monograph & all interactions
Keep checking

Other Drugs & Clove

Browse every other medication we’ve checked against Clove — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
918Moderate
60Minor
1,851No known interaction
918 Moderate 60 Minor 1,851 No interaction
Moderate

918 interactions

Showing 60 of 918 moderate interactions — see all 918 on the Clove page.

Minor

60 interactions

No interaction 1,851 drugs checked — show the list

We also checked Clove against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,851 medications checked with no known interaction — see the full Clove list.

See the full Clove interactions page
See every supplement checked against Insulin Aspart, Insulin Degludec, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Clove monograph › Uses, safety, and every drug interaction in one place Insulin Aspart, Insulin Degludec supplement interactions › Every supplement checked against Insulin Aspart, Insulin Degludec, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Clove and Insulin Aspart, Insulin Degludec Together: Common Questions

Can you take Clove with Insulin Aspart, Insulin Degludec?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Clove and Insulin Aspart, Insulin Degludec interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Aspart, Insulin Degludec and Clove?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.