Drug & supplement interaction

Adenosine + Paclitaxel

Paclitaxel brand names: Taxol, Abraxane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Adenosine and Paclitaxel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Adenosine and Paclitaxel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paclitaxel and Adenosine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Adenosine safety at a glance

Adenosine overall Use caution Oral supplement evidence is limited; the prescription injectable form is powerful and must only be given by medical professionals.
Pregnancy Avoid There is not enough safety information for supplement use, so it is best avoided.
Breastfeeding Avoid Safety has not been established, so avoid supplement use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paclitaxel and Adenosine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Paclitaxel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Paclitaxel is filed under 6 classifications — including cytochrome p450 2c8 (cyp2c8) substrates, organic anion-transporting polypeptide substrates (oatp), p-glycoprotein substrates. Adenosine has documented interactions with 3 drug classes — the most serious being dipyridamole (persantine) (major), carbamazepine (tegretol) (moderate) and methylxanthines (minor) — and none of Paclitaxel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Adenosine Does Interact With Other Medications

Adenosine has 2 major, 1 moderate, 44 minor known drug interactions in our database — Paclitaxel isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 1 Minor 44 No known interaction 2,783 (incl. Paclitaxel)
Taking anything else?

Check Another of Your Medications Against Adenosine

Covers the 2,830 medications we’ve checked against Adenosine. Pick one to open its full report.

What to actually watch for

What Adenosine Itself Has Been Linked To

This is not an interaction — nothing below involves Paclitaxel. It is the side-effect record for Adenosine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Adenosine, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • A heart attack / An irregular heartbeat / Chest pain Worth acting on Additional detail

    “Intravenously, adenosine causes chest pain, palpitations, hypotension, and supraventricular tachycardia (15,9148). Intravenous adenosine has also been associated with arrhythmias, fatal or nonfatal cardiac arrest, ventricular tachycardia, and myocardial infarction (15). Intravenously, adenosine triphosphate (ATP) causes chest pain, particularly at doses greater than 50 mcg/kg per minute.”

    Adenosine · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 9148. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
    3. 9154. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  • Seizures Worth acting on Additional detail

    “Rapid intravenous injection of adenosine can cause headache, lightheadedness, insomnia, and anxiety. New onset seizures, including tonic-clonic seizures, have also occurred (15). Intrathecally, adenosine has been reported to cause headache.”

    Adenosine · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 9148. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
    2. 9151. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
    3. 9152. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
    4. 9154. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
    5. 9158. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
    6. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  • Shortness of breath / An allergic reaction Worth acting on Additional detail

    Recorded for Adenosine in the same Natural Medicines adverse-effect record shown under A heart attack / An irregular heartbeat / Chest pain above.

  • Flushing Additional detail

    “Intravenously, adenosine causes flushing in up to 44% of patients in clinical research (15). Topically, folliculitis and pruritus can occur after application of adenosine to the scalp.”

    Adenosine · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 93689. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.
  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Recorded for Adenosine in the same Natural Medicines adverse-effect record shown under A heart attack / An irregular heartbeat / Chest pain above.

  • Numbness or tingling Additional detail

    Recorded for Adenosine in the same Natural Medicines adverse-effect record shown under A heart attack / An irregular heartbeat / Chest pain above.

Showing the 10 most notable of 16 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Adenosine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Paclitaxel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Paclitaxel column appears here.

Overlapping uses

What Paclitaxel Is Prescribed For, and What Adenosine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Paclitaxel is a prescription medicine with approved uses on its FDA label. Adenosine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Paclitaxel is prescribed for: Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is used to treat three types of cancer. It treats metastatic breast cancer in patients whose prior chemotherapy has stopped working or who relapsed within 6 months of completing adjuvant (post-surgery) chemotherapy. It is also used as a first-line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC) — given together with carboplatin — in patients who cannot have surgery or radiation therapy. Additionally, it is approved as a first-line treatment for metastatic adenocarcinoma of the pancreas, given in combination with gemcitabine.

Read the rest of what Paclitaxel is prescribed for

All three uses apply specifically to Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound), including the brands Abraxane and related albumin-bound formulations.

Adenosine has been studied for:

  • Lung cancer studied, not established Adenosine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Adenosine for lung cancer

    Intravenous adenosine triphosphate does not seem to be beneficial in patients with advanced non-small-cell lung cancer (NSCLC). Oral adenosine has not been evaluated for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Paclitaxel on your own; if you are taking Adenosine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Paclitaxel

This page covers Adenosine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paclitaxel page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Grapefruit (major), St. John's Wort (major) and Sweet Orange (major).

By severity: 5 major · 108 moderate · 39 minor.

Open the Paclitaxel interaction page

One more smart check

Taking Adenosine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 66 real supplement products containing Adenosine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Adenosine. Even though Adenosine itself has no known interaction with Paclitaxel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Adenosine and Paclitaxel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Adenosine
Top 25%

#290 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paclitaxel
Steady interest

#1,884 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Adenosine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Adenosine and Paclitaxel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Adenosine

What is Adenosine?

Adenosine
  • Energy and cellular function support
  • Athletic performance and muscle energy
  • Circulation support
  • General wellness

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-the-counter supplement (often sold as AMP or ATP), there is little strong evidence that swallowing it boosts energy or performance, and quality can vary. Talk to your pharmacist before using adenosine supplements, especially if you have a heart condition.

Naturally occurring purine nucleoside found in all body cells; supplement forms are made synthetically · Tablets, capsules, sublingual tablets, powders (often as AMP or ATP); prescription injectable form (separate from supplements)

An interaction check asks whether these two react with each other — it does not ask whether Adenosine is a good idea for someone in your situation. Here is what our Adenosine record says about it on its own.

Adenosine: dosing

There is no established standard dose for adenosine supplements. Products vary widely in form (AMP, ATP, or adenosine) and in the amounts they contain.If you choose to use a supplement, follow the directions on the product label and do not take more than recommended. Because supplements are not tightly regulated, quality and actual content can differ between brands; choosing products that have been independently tested can help.The prescription injectable dose is determined and given by a doctor and does not apply to supplement use.

From our Adenosine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Adenosine monograph & all interactions
Medication

About Paclitaxel (with albumin) Injection

What Is Paclitaxel (with albumin) Injection Used For?

Brand names: Taxol, Abraxane

Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is used to treat three types of cancer. It treats metastatic breast cancer in patients whose prior chemotherapy has stopped working or who relapsed within 6 months of completing adjuvant (post-surgery) chemotherapy. It is also used as a first-line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC) — given together with carboplatin — in patients who cannot have surgery or radiation therapy.

Additionally, it is approved as a first-line treatment for metastatic adenocarcinoma of the pancreas, given in combination with gemcitabine. All three uses apply specifically to Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound), including the brands Abraxane and related albumin-bound formulations.

Most-Reported Side Effects for Paclitaxel

From FAERS, the FDA’s public side-effect reporting system (98,465 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 5,500 reports
Neutropenia 5,424 reports
Diarrhea 5,152 reports
Dyspnea 5,113 reports
Anemia 4,794 reports
See full Paclitaxel (with albumin) Injection drug information
Keep checking

Other Drugs & Adenosine

Browse every other medication we’ve checked against Adenosine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
1Moderate
44Minor
2,782No known interaction
2 Major 1 Moderate 44 Minor 2,782 No interaction
Major

2 interactions

Moderate

1 interaction

Minor

44 interactions

No interaction 2,782 drugs checked — show the list

We also checked Adenosine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,782 medications checked with no known interaction — see the full Adenosine list.

See the full Adenosine interactions page
See every supplement checked against Paclitaxel, ranked by severity
Evidence & sources

Adenosine References

The 10 references that drive our Adenosine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Adenosine and Paclitaxel Together: Common Questions

Is it safe to take Adenosine with Paclitaxel?
We do not list a known interaction between Adenosine and Paclitaxel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Adenosine and Paclitaxel used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Adenosine in each. That is a conversation for your prescriber, especially if Paclitaxel is being adjusted to a target.
How was the Adenosine and Paclitaxel combination checked?
Interactions in our licensed database are recorded against drug classes. Paclitaxel is filed under 6 classifications, and Adenosine has documented interactions with 3 drug classes — none of Paclitaxel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Adenosine interact with any other medications?
Yes. Adenosine has 47 documented drug interactions in our database — Paclitaxel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Paclitaxel interact with any supplements?
Yes. Paclitaxel has documented interactions with 152 supplements in our database — Adenosine is not one of them. The Paclitaxel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Adenosine monograph Uses, safety profile, and every drug interaction in one place Paclitaxel (with albumin) Injection drug information The full plain-English guide to this medication Paclitaxel supplement interactions Every supplement checked against Paclitaxel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paclitaxel and Adenosine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.