Drug & supplement interaction

Adenosine + Sotatercept-csrk

Sotatercept-csrk brand name: Winrevair.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Adenosine and Sotatercept-csrk in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Adenosine and Sotatercept-csrk

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sotatercept-csrk and Adenosine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Adenosine safety at a glance

Adenosine overall Use caution Oral supplement evidence is limited; the prescription injectable form is powerful and must only be given by medical professionals.
Pregnancy Avoid There is not enough safety information for supplement use, so it is best avoided.
Breastfeeding Avoid Safety has not been established, so avoid supplement use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sotatercept-csrk and Adenosine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Adenosine Does Interact With Other Medications

Adenosine has 2 major, 1 moderate, 44 minor known drug interactions in our database — Sotatercept-csrk isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 1 Minor 44 No known interaction 2,783 (incl. Sotatercept-csrk)
Taking anything else?

Check Another of Your Medications Against Adenosine

Covers the 2,830 medications we’ve checked against Adenosine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Adenosine and Sotatercept-csrk May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness / Headache reported in 13.4% of FDA reports for Sotatercept-csrk Additional detail

    Adenosine

    “Rapid intravenous injection of adenosine can cause headache, lightheadedness, insomnia, and anxiety. New onset seizures, including tonic-clonic seizures, have also occurred (15). Intrathecally, adenosine has been reported to cause headache.”

    Adenosine · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 9148. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
    2. 9151. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
    3. 9152. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
    4. 9154. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
    5. 9158. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
    6. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

    Sotatercept-csrk

    Listed in the ADVERSE REACTIONS section of the FDA label for Sotatercept-csrk, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Adenosine but not commonly for Sotatercept-csrk: an irregular heartbeat, a heart attack, an allergic reaction and flushing.

Effects for Sotatercept-csrk come from the ADVERSE REACTIONS section of its FDA label; effects for Adenosine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,905 voluntary FDA FAERS reports for Sotatercept-csrk that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Sotatercept-csrk Is Prescribed For, and What Adenosine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Sotatercept-csrk is a prescription medicine with approved uses on its FDA label. Adenosine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Sotatercept-csrk is prescribed for: Sotatercept-csrk (sold as Winrevair) treats adults with pulmonary arterial hypertension (PAH, also called WHO Group 1 pulmonary hypertension). This is high blood pressure in the arteries of the lungs. It is used to improve exercise capacity and WHO functional class (a rating of how much PAH limits daily activity). It also lowers the risk of clinical worsening events, including hospitalization for PAH, lung transplantation and death.

Adenosine has been studied for:

  • Pulmonary hypertension studied, not established Adenosine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Adenosine for pulmonary hypertension

    Adenosine given by central venous infusion might be beneficial in patients who develop pulmonary hypertension during cardiac surgery.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sotatercept-csrk on your own; if you are taking Adenosine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Adenosine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 66 real supplement products containing Adenosine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Adenosine. Even though Adenosine itself has no known interaction with Sotatercept-csrk, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Adenosine and Sotatercept-csrk Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Adenosine
Top half

#379 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sotatercept-csrk
Top half

#812 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Adenosine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Adenosine and Sotatercept-csrk records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Adenosine

What is Adenosine?

Adenosine
  • Energy and cellular function support
  • Athletic performance and muscle energy
  • Circulation support
  • General wellness

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-the-counter supplement (often sold as AMP or ATP), there is little strong evidence that swallowing it boosts energy or performance, and quality can vary. Talk to your pharmacist before using adenosine supplements, especially if you have a heart condition.

Naturally occurring purine nucleoside found in all body cells; supplement forms are made synthetically · Tablets, capsules, sublingual tablets, powders (often as AMP or ATP); prescription injectable form (separate from supplements)

An interaction check asks whether these two react with each other — it does not ask whether Adenosine is a good idea for someone in your situation. Here is what our Adenosine record says about it on its own.

Adenosine: dosing

There is no established standard dose for adenosine supplements. Products vary widely in form (AMP, ATP, or adenosine) and in the amounts they contain.If you choose to use a supplement, follow the directions on the product label and do not take more than recommended. Because supplements are not tightly regulated, quality and actual content can differ between brands; choosing products that have been independently tested can help.The prescription injectable dose is determined and given by a doctor and does not apply to supplement use.

From our Adenosine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Adenosine monograph & all interactions
Medication

About Sotatercept-Csrk

What Is Sotatercept-Csrk Used For?

Brand name: Winrevair

Sotatercept-csrk (sold as Winrevair) treats adults with pulmonary arterial hypertension (PAH, also called WHO Group 1 pulmonary hypertension). This is high blood pressure in the arteries of the lungs.

It is used to improve exercise capacity and WHO functional class (a rating of how much PAH limits daily activity). It also lowers the risk of clinical worsening events, including hospitalization for PAH, lung transplantation and death.

Most-Reported Side Effects for Sotatercept-csrk

From FAERS, the FDA’s public side-effect reporting system (5,010 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 668 reports
Dyspnea 544 reports
Diarrhea 521 reports
Epistaxis 443 reports
Fatigue 416 reports
See full Sotatercept-Csrk drug information
Keep checking

Other Drugs & Adenosine

Browse every other medication we’ve checked against Adenosine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
1Moderate
44Minor
2,782No known interaction
2 Major 1 Moderate 44 Minor 2,782 No interaction
Major

2 interactions

Moderate

1 interaction

Minor

44 interactions

No interaction 2,782 drugs checked — show the list

We also checked Adenosine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,782 medications checked with no known interaction — see the full Adenosine list.

See the full Adenosine interactions page
See every supplement checked against Sotatercept-csrk, ranked by severity
Evidence & sources

Adenosine References

The 10 references that drive our Adenosine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Adenosine and Sotatercept-csrk Together: Common Questions

Is it safe to take Adenosine with Sotatercept-csrk?
We do not list a known interaction between Adenosine and Sotatercept-csrk. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Adenosine and Sotatercept-csrk have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Adenosine and Sotatercept-csrk used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Adenosine in each. That is a conversation for your prescriber, especially if Sotatercept-csrk is being adjusted to a target.
Does Adenosine interact with any other medications?
Yes. Adenosine has 47 documented drug interactions in our database — Sotatercept-csrk is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Adenosine monograph Uses, safety profile, and every drug interaction in one place Sotatercept-Csrk drug information The full plain-English guide to this medication Sotatercept-csrk supplement interactions Every supplement checked against Sotatercept-csrk, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sotatercept-csrk and Adenosine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.