Drug & supplement interaction

American Ivy + Esomeprazole, Naproxen

Esomeprazole, Naproxen brand name: Vimovo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between American Ivy and Esomeprazole, Naproxen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Esomeprazole, Naproxen states a food rule worth keeping to.

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Interaction report

American Ivy and Esomeprazole, Naproxen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esomeprazole, Naproxen and American Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ivy safety at a glance

American Ivy overall Use caution Little safety data exists, and the berries are toxic, so use it cautiously and avoid eating any part of the plant.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esomeprazole, Naproxen and American Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Esomeprazole, Naproxen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Esomeprazole, Naproxen is filed under 15 classifications — including proton pump inhibitors (ppis), cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 1a2 (cyp1a2) inducers. American Ivy has documented interactions with 1 drug class — the most serious being thiazide diuretics (moderate) — and none of Esomeprazole, Naproxen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Ivy Does Interact With Other Medications

American Ivy has 56 moderate known drug interactions in our database — Esomeprazole, Naproxen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 56 No known interaction 2,774 (incl. Esomeprazole, Naproxen)
Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

What to actually watch for

What Esomeprazole, Naproxen’s Own FDA Label Lists

This is not an interaction — none of it involves American Ivy. These are the most notable effects listed in the ADVERSE REACTIONS section of Esomeprazole, Naproxen’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low magnesium Worth acting on
  • Bone thinning Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Heart failure Worth acting on
  • A severe skin reaction Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on

Showing the 10 most notable of 33 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Esomeprazole, Naproxen. Read the label on DailyMed › American Ivy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Ivy side to compare — that is a limit of the record, not a statement that American Ivy has no side effects.

How to take them

Some Esomeprazole, Naproxen Products Have a Food Rule — American Ivy Should Not Break It

At least one FDA label for a product containing Esomeprazole, Naproxen says to take it on an empty stomach. Most supplements — American Ivy included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Esomeprazole, Naproxen on its own and move American Ivy to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Esomeprazole, Naproxen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Take naproxen and esomeprazole magnesium delayed-release tablets at least 30 minutes before meals.

From the Dosage and Administration section of the FDA label we read for Esomeprazole, Naproxen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Esomeprazole, Naproxen

This page covers American Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esomeprazole, Naproxen page lists 348 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Grapefruit (major).

By severity: 9 major · 283 moderate · 56 minor.

From our pharmacist’s overview on the Esomeprazole, Naproxen page

“Bleeding risk is the thread running through nearly this whole page. Vimovo pairs naproxen, an anti-inflammatory that already makes stomach bleeding more likely, with esomeprazole on board to shield the gut, and most of the supplements flagged here could push that bleeding risk higher still.”

Reviewed by 2 · Jul 18, 2026

Open the Esomeprazole, Naproxen interaction page

How much people look this up

Where American Ivy and Esomeprazole, Naproxen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy
Steady interest

#1,243 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esomeprazole, Naproxen
Steady interest

#1,641 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Ivy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ivy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Ivy and Esomeprazole, Naproxen records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Ivy

What is American Ivy?

American Ivy
  • Digestive upset
  • To stimulate sweating
  • Traditional tonic use
  • Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Parthenocissus quinquefolia · Vitaceae · Bark, leaves, and stems (berries are considered poisonous) · Dried bark, tinctures, teas; rarely sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether American Ivy is a good idea for someone in your situation. Here is what our American Ivy record says about it on its own.

American Ivy: dosing

There is no established safe or effective dose for American Ivy. It is not a standardized supplement, so the strength of any product can vary a lot.If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Never make a home preparation from the raw plant or its berries.

From our American Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ivy monograph & all interactions
Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
56Moderate
0Minor
2,773No known interaction
56 Moderate 2,773 No interaction
Moderate

56 interactions

No interaction 2,773 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,773 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page
See every supplement checked against Esomeprazole, Naproxen, ranked by severity
Evidence & sources

American Ivy References

The 1 sources that drive our American Ivy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Ivy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Oxalates — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ivy and Esomeprazole, Naproxen Together: Common Questions

Is it safe to take American Ivy with Esomeprazole, Naproxen?
We do not list a known interaction between American Ivy and Esomeprazole, Naproxen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take American Ivy and Esomeprazole, Naproxen at the same time of day?
At least one FDA label for a product containing Esomeprazole, Naproxen says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Esomeprazole, Naproxen on its own and move American Ivy to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the American Ivy and Esomeprazole, Naproxen combination checked?
Interactions in our licensed database are recorded against drug classes. Esomeprazole, Naproxen is filed under 15 classifications, and American Ivy has documented interactions with 1 drug class — none of Esomeprazole, Naproxen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Ivy interact with any other medications?
Yes. American Ivy has 56 documented drug interactions in our database — Esomeprazole, Naproxen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Esomeprazole, Naproxen interact with any supplements?
Yes. Esomeprazole, Naproxen has documented interactions with 348 supplements in our database — American Ivy is not one of them. The Esomeprazole, Naproxen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ivy monograph Uses, safety profile, and every drug interaction in one place Esomeprazole, Naproxen supplement interactions Every supplement checked against Esomeprazole, Naproxen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esomeprazole, Naproxen and American Ivy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.