Medication interaction hub

What Supplements Interact with Esomeprazole, Naproxen?

Esomeprazole, Naproxen brand name: Vimovo. Every interaction below applies to the brands too.

348 Interactions 9 Major 283 Moderate 56 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Esomeprazole, Naproxen? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Esomeprazole, Naproxen against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bleeding risk is the thread running through nearly this whole page. Vimovo pairs naproxen, an anti-inflammatory that already makes stomach bleeding more likely, with esomeprazole on board to shield the gut, and most of the supplements flagged here could push that bleeding risk higher still. Even beer and wine qualify, since alcohol taken alongside an NSAID raises the odds of a stomach bleed. These combinations call for real care, not casual mixing.

A second cluster changes how the body handles the medicine itself. Grapefruit can drive drug levels up, St. John's wort can pull them down, and activated charcoal can simply soak up an oral dose. A few others, Siberian cocklebur among them, add strain on kidneys that naproxen already taxes. All told, 348 ingredients are on file, and while only 9 rate major, those 9 are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 283 Minor 56 No known interaction 1,104

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Esomeprazole, Naproxen: Top Interactions at a Glance

The Esomeprazole, Naproxen supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 348 interacting ingredients — plus 1,104 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Esomeprazole, Naproxen Combinations Today

The Esomeprazole, Naproxen + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Esomeprazole, Naproxeni

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Read the full interaction Moderate Likelihood Possible Cannabis + Esomeprazole, Naproxeni

Cannabis may increase levels of drugs metabolized by CYP2C19.

Read the full interaction Moderate Likelihood Probable Willow Bark + Esomeprazole, Naproxeni

Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Sea Buckthorn + Esomeprazole, Naproxeni

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Esomeprazole, Naproxeni

Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.

Read the full interaction Moderate Likelihood Possible Cabbage + Esomeprazole, Naproxeni

Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.

Read the full interaction
The complete list

Every Supplement Checked Against Esomeprazole, Naproxen

All 1,452 ingredients in our database, ranked by severity — 348 with a Esomeprazole, Naproxen interaction on file and 1,104 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Esomeprazole, Naproxen?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Esomeprazole, Naproxen?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Full Betaine Hydrochloride + Esomeprazole, Naproxen answer

Can you take Cannabis with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis may increase levels of drugs metabolized by CYP2C19.

Full Cannabis + Esomeprazole, Naproxen answer

Can you take Willow Bark with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Willow Bark + Esomeprazole, Naproxen answer

Can you take Sea Buckthorn with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Sea Buckthorn + Esomeprazole, Naproxen answer

Can you take Eucalyptus with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.

Full Eucalyptus + Esomeprazole, Naproxen answer

Can you take Lycopene with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Esomeprazole, Naproxen answer

Can you take Mace with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzym...

Full Mace + Esomeprazole, Naproxen answer

Can you take Magnolia with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Magnolia + Esomeprazole, Naproxen answer

Can you take Mangosteen with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Full Mangosteen + Esomeprazole, Naproxen answer

Can you take Maral Root with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that maral root tincture can reduce platelet aggregation.

Full Maral Root + Esomeprazole, Naproxen answer

Can you take Maritime Pine with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Maritime Pine + Esomeprazole, Naproxen answer

Can you take Marjoram with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion.

Full Marjoram + Esomeprazole, Naproxen answer

Can you take Mesoglycan with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combined use might increase bleeding risk.

Full Mesoglycan + Esomeprazole, Naproxen answer

Can you take Methoxylated Flavones with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.

Full Methoxylated Flavones + Esomeprazole, Naproxen answer

Can you take Moringa with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Esomeprazole, Naproxen answer

Can you take Mountain Ash with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Esomeprazole, Naproxen answer

Can you take N-acetyl Cysteine (nac) with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full N-acetyl Cysteine (nac) + Esomeprazole, Naproxen answer

Can you take Nattokinase with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Esomeprazole, Naproxen answer

Can you take Neem with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.

Full Neem + Esomeprazole, Naproxen answer

Can you take Niacin with Esomeprazole, Naproxen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Esomeprazole, Naproxen answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Esomeprazole, Naproxen is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Esomeprazole, Naproxen, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Esomeprazole, Naproxen sits in 15 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Proton Pump Inhibitors (Ppis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Esomeprazole, Naproxen through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Esomeprazole, Naproxen through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Esomeprazole, Naproxen through this category.

Related: does Esomeprazole, Naproxen deplete any nutrients?

Esomeprazole, Naproxen has 10 reported nutrient associations in the research literature — see the Esomeprazole, Naproxen nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Esomeprazole, Naproxen

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Esomeprazole, Naproxen.

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Pharmacist Counseling Corner

Esomeprazole, Naproxen & Supplements: Common Questions

What supplements interact with Esomeprazole, Naproxen?
More than you might expect — 348 in total, though they are far from equal: 9 are rated major, 283 moderate, and 56 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Esomeprazole, Naproxen supplement interactions are the most serious?
The 9 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Danshen — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Esomeprazole, Naproxen?
Usually yes — most people on Esomeprazole, Naproxen can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Vimovo have the same supplement interactions as Esomeprazole, Naproxen?
Yes — Vimovo all contain Esomeprazole, Naproxen, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Esomeprazole, Naproxen deplete any vitamins or nutrients?
It might — Esomeprazole, Naproxen has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Esomeprazole, Naproxen nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Esomeprazole, Naproxen and my other medications?
This page covers Esomeprazole, Naproxen against supplements and herbal ingredients. Checking Esomeprazole, Naproxen against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.