Drug & supplement interaction

American Spikenard + Mitotane

Mitotane brand name: Lysodren.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between American Spikenard and Mitotane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mitotane states a food rule worth keeping to.

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Interaction report

American Spikenard and Mitotane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mitotane and American Spikenard in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Spikenard safety at a glance

American Spikenard overall Use caution Little is known about its safety from modern studies, so use cautiously and short-term.
Pregnancy Possibly Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding due to a lack of safety information.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mitotane and American Spikenard? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mitotane

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mitotane is filed under a single classification — oral drugs. American Spikenard has documented interactions with 1 drug class — the most serious being diuretic drugs (minor) — and none of Mitotane’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Spikenard Does Interact With Other Medications

American Spikenard has 75 minor known drug interactions in our database — Mitotane isn’t one of them. If you take anything else, check it against the full list below.

Minor 75 No known interaction 2,755 (incl. Mitotane)
Taking anything else?

Check Another of Your Medications Against American Spikenard

Covers the 2,830 medications we’ve checked against American Spikenard. Pick one to open its full report.

What to actually watch for

What Mitotane’s Own FDA Label Lists

This is not an interaction — none of it involves American Spikenard. These are the most notable effects listed in the ADVERSE REACTIONS section of Mitotane’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • Muscle weakness Worth acting on
  • Unsteadiness Worth acting on
  • Confusion Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on

Showing the 10 most notable of 29 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mitotane. Read the label on DailyMed › American Spikenard’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Spikenard side to compare — that is a limit of the record, not a statement that American Spikenard has no side effects.

Special populations

American Spikenard in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Mitotane Products Have a Food Rule — American Spikenard Should Not Break It

At least one FDA label for a product containing Mitotane says to take it with food. If you take American Spikenard on an empty stomach out of habit, keep them separate — and take Mitotane with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mitotane products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended initial dose of LYSODREN is 2000 mg to 6000 mg orally, in three or four divided doses per day with food.

From the Dosage and Administration section of the FDA label we read for Mitotane — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mitotane

This page covers American Spikenard only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mitotane page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Mitotane page

“Mitotane (Lysodren) is chemotherapy for adrenal cancer, and doses are adjusted based on blood levels, so a supplement list like this one deserves genuine attention rather than a shrug. All 17 entries work the same basic way, by changing how much mitotane your gut actually takes in.”

Reviewed by 2 · Jul 18, 2026

Open the Mitotane interaction page

How much people look this up

Where American Spikenard and Mitotane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Spikenard
Steady interest

#822 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mitotane
Top half

#1,183 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Spikenard reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The American Spikenard and Mitotane records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Spikenard

What is American Spikenard?

American Spikenard
  • Cough and chest congestion
  • Common cold
  • Asthma symptoms
  • Promoting sweating
  • Skin and wound support (topical)

American spikenard is a traditional North American herb used mainly as an expectorant and to ease coughs and colds, but there is no reliable human research to confirm it works. If you choose to try it, use it short-term, follow the product label, and check with a pharmacist or doctor first—especially if you are pregnant, breastfeeding, or have a health condition.

Aralia racemosa · Araliaceae · Root and rhizome · Tea, tincture, dried root, capsules, syrup

An interaction check asks whether these two react with each other — it does not ask whether American Spikenard is a good idea for someone in your situation. Here is what our American Spikenard record says about it on its own.

American Spikenard: dosing

There is no established or standardized dose for American spikenard. Traditional preparations include teas made from the dried root, tinctures, and syrups, but reliable dosing guidelines based on research do not exist.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our American Spikenard monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Spikenard monograph & all interactions
Medication

About Mitotane

What Is Mitotane Used For?

Brand name: Lysodren

Lysodren (mitotane) tablets are indicated for the treatment of inoperable adrenocortical carcinoma (ACC) — a rare cancer of the adrenal gland's outer layer (the cortex). It can be used whether or not the tumor is actively producing hormones (functional or nonfunctional).

Because the cancer cannot be removed surgically in these patients, Lysodren works to suppress and damage the adrenal tissue itself, helping to control the disease.

See full Mitotane drug information
Keep checking

Other Drugs & American Spikenard

Browse every other medication we’ve checked against American Spikenard — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
75Minor
2,754No known interaction
75 Minor 2,754 No interaction
Minor

75 interactions

Showing 60 of 75 minor interactions — see all 75 on the American Spikenard page.

No interaction 2,754 drugs checked — show the list

We also checked American Spikenard against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,754 medications checked with no known interaction — see the full American Spikenard list.

See the full American Spikenard interactions page
See every supplement checked against Mitotane, ranked by severity
Evidence & sources

American Spikenard References

The 1 references that drive our American Spikenard monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Spikenard and Mitotane Together: Common Questions

Is it safe to take American Spikenard with Mitotane?
We do not list a known interaction between American Spikenard and Mitotane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take American Spikenard and Mitotane at the same time of day?
At least one FDA label for a product containing Mitotane says to take it with food. If you take American Spikenard on an empty stomach out of habit, keep them separate and take Mitotane with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Mitotane products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the American Spikenard and Mitotane combination checked?
Interactions in our licensed database are recorded against drug classes. Mitotane is filed under 1 classification, and American Spikenard has documented interactions with 1 drug class — none of Mitotane's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Spikenard interact with any other medications?
Yes. American Spikenard has 75 documented drug interactions in our database — Mitotane is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mitotane interact with any supplements?
Yes. Mitotane has documented interactions with 17 supplements in our database — American Spikenard is not one of them. The Mitotane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Spikenard monograph Uses, safety profile, and every drug interaction in one place Mitotane drug information The full plain-English guide to this medication Mitotane supplement interactions Every supplement checked against Mitotane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mitotane and American Spikenard?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.