Drug & supplement interaction

American Spikenard + Hydrochlorothiazide, Lisinopril

Hydrochlorothiazide, Lisinopril brand names: Zestoretic, Prinzide.

Minor Interaction
Medically reviewed by · Updated February 2024
The bottom line Minor

American Spikenard has a minor interaction with Hydrochlorothiazide, Lisinopril. American spikenard is purported to have diaphoretic properties.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

American Spikenard and Hydrochlorothiazide, Lisinopril

Here is the interaction we found between these two, with the evidence behind it.

Minor

Diuretic Drugs

Why this applies to Hydrochlorothiazide, Lisinopril

Hydrochlorothiazide, Lisinopril falls under Diuretic Drugs — the group American Spikenard interacts with.

American spikenard is purported to have diaphoretic properties. Diaphoretic substances can increase sweating and fluid loss from the body, which may enhance the effects of diuretics. This interaction could potentially lead to excessive fluid loss and electrolyte imbalance, especially in individuals taking diuretic medications. Healthcare providers need to monitor patients closely for signs of dehydration or electrolyte disturbances if they are using both Aralia racemosa and diuretic drugs concurrently.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your blood pressure pill is really two medicines in one. The hydrochlorothiazide part is a water pill that already makes you pee out extra fluid and salt. American spikenard has a traditional reputation for making you sweat (what older books call a 'diaphoretic'). The worry here is simple: a water pill plus something that makes you sweat could add up to losing a little too much fluid.

If that happened, you might feel lightheaded, dizzy, very thirsty, or weak, and your potassium or sodium could drift off. Honestly, this is rated minor and rests on weak, theoretical evidence, so for most people it is not a big deal. Still, stay well hydrated, and check with your pharmacist or doctor before combining them, especially in hot weather.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

American Spikenard Also Interacts With Other Medications

American Spikenard has 74 minor known drug interactions in our database — the Hydrochlorothiazide, Lisinopril one above is one of them. If you take anything else, check it against the full list below.

Minor 74 No known interaction 2,756 (incl. Hydrochlorothiazide, Lisinopril)
Taking anything else?

Check Another of Your Medications Against American Spikenard

Covers the 2,830 medications we’ve checked against American Spikenard. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Lisinopril

This page covers American Spikenard only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Lisinopril page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Lisinopril page

“I would not add a supplement casually alongside hydrochlorothiazide and lisinopril (Zestoretic, Prinzide). This combination lowers blood pressure with a water pill plus an ACE inhibitor, and most interacting ingredients either drag pressure down too far or push back against the drug, while smaller groups strain the kidneys, drain potas…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Lisinopril interaction page

How much people look this up

Where American Spikenard and Hydrochlorothiazide, Lisinopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Spikenard
Top half

#378 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Lisinopril
Top 25%

#698 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About American Spikenard

What is American Spikenard?

American Spikenard
  • Cough and chest congestion
  • Common cold
  • Asthma symptoms
  • Promoting sweating
  • Skin and wound support (topical)

American spikenard is a traditional North American herb used mainly as an expectorant and to ease coughs and colds, but there is no reliable human research to confirm it works. If you choose to try it, use it short-term, follow the product label, and check with a pharmacist or doctor first—especially if you are pregnant, breastfeeding, or have a health condition.

Read the full American Spikenard monograph & all interactions
Medication

About Lisinopril and Hydrochlorothiazide

What Is Lisinopril and Hydrochlorothiazide Used For?

Brand names: Zestoretic, Prinzide

Lisinopril and hydrochlorothiazide tablets — sold under the brand name Zestoretic and as the generic combination — are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events, including strokes and heart attacks.

This combination is not intended as a first-line starting treatment. It is typically used when a single blood pressure medication alone has not been enough to reach target blood pressure goals.

See full Lisinopril and Hydrochlorothiazide drug information
Keep checking

Other Drugs & American Spikenard

Browse every other medication we’ve checked against American Spikenard — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
74Minor
2,755No known interaction
74 Minor 2,755 No interaction
Minor

74 interactions

Showing 60 of 74 minor interactions — see all 74 on the American Spikenard page.

No interaction 2,755 drugs checked — show the list

We also checked American Spikenard against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,755 medications checked with no known interaction — see the full American Spikenard list.

See the full American Spikenard interactions page
See every supplement checked against Hydrochlorothiazide, Lisinopril, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
American Spikenard monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Lisinopril supplement interactions › Every supplement checked against Hydrochlorothiazide, Lisinopril, ranked by severity Lisinopril and Hydrochlorothiazide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking American Spikenard and Hydrochlorothiazide, Lisinopril Together: Common Questions

Can you take American Spikenard with Hydrochlorothiazide, Lisinopril?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the American Spikenard and Hydrochlorothiazide, Lisinopril interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrochlorothiazide, Lisinopril and American Spikenard?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.