Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Lisinopril?

Hydrochlorothiazide, Lisinopril brand names: Zestoretic, Prinzide. Every interaction below applies to the brands too.

236 Interactions 10 Major 199 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Lisinopril? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Lisinopril against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

I would not add a supplement casually alongside hydrochlorothiazide and lisinopril (Zestoretic, Prinzide). This combination lowers blood pressure with a water pill plus an ACE inhibitor, and most interacting ingredients either drag pressure down too far or push back against the drug, while smaller groups strain the kidneys, drain potassium, or carry heart toxicity of their own. Even ordinary activated charcoal earns a major rating because it can keep the tablet from absorbing.

Calcium is another everyday one to watch, since the thiazide half holds calcium in the body and large doses risk a harmful buildup. Twenty of the herbs also raise sun sensitivity, a side effect hydrochlorothiazide can cause on its own. Space other oral products well apart from your dose and check the serious entries against whatever you already take. The full list runs 236 ingredients, 199 rated moderate and 27 minor, with ten majors that deserve your attention first.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 199 Minor 27 No known interaction 1,216

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Lisinopril: Top Interactions at a Glance

The Hydrochlorothiazide, Lisinopril supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 236 interacting ingredients — plus 1,216 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Lisinopril Combinations Today

The Hydrochlorothiazide, Lisinopril + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Nattokinase + Hydrochlorothiazide, Lisinoprili

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible N-acetyl Cysteine (nac) + Hydrochlorothiazide, Lisinoprili

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Berberine + Hydrochlorothiazide, Lisinoprili

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Celery + Hydrochlorothiazide, Lisinoprili

Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Goji + Hydrochlorothiazide, Lisinoprili

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Read the full interaction Moderate Likelihood Possible Danshen + Hydrochlorothiazide, Lisinoprili

Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Lisinopril

All 1,452 ingredients in our database, ranked by severity — 236 with a Hydrochlorothiazide, Lisinopril interaction on file and 1,216 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Lisinopril?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Nattokinase with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Hydrochlorothiazide, Lisinopril answer

Can you take N-acetyl Cysteine (nac) with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Full N-acetyl Cysteine (nac) + Hydrochlorothiazide, Lisinopril answer

Can you take Berberine with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Hydrochlorothiazide, Lisinopril answer

Can you take Celery with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Hydrochlorothiazide, Lisinopril answer

Can you take Goji with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Full Goji + Hydrochlorothiazide, Lisinopril answer

Can you take Niacin with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Hydrochlorothiazide, Lisinopril answer

Can you take Noni with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Full Noni + Hydrochlorothiazide, Lisinopril answer

Can you take Octopamine with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.

Full Octopamine + Hydrochlorothiazide, Lisinopril answer

Can you take Oolong Tea with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.

Full Oolong Tea + Hydrochlorothiazide, Lisinopril answer

Can you take Oregon Grape with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.

Full Oregon Grape + Hydrochlorothiazide, Lisinopril answer

Can you take Parsley with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Hydrochlorothiazide, Lisinopril answer

Can you take Pheasant's Eye with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Pheasant's Eye + Hydrochlorothiazide, Lisinopril answer

Can you take Phellodendron with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.

Full Phellodendron + Hydrochlorothiazide, Lisinopril answer

Can you take Pleurisy Root with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Hydrochlorothiazide, Lisinopril answer

Can you take Pomegranate with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Hydrochlorothiazide, Lisinopril answer

Can you take Quassia with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of quassia might compound diuretic-induced potassium loss.

Full Quassia + Hydrochlorothiazide, Lisinopril answer

Can you take Quercetin with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Full Quercetin + Hydrochlorothiazide, Lisinopril answer

Can you take Rauvolfia Vomitoria with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.

Full Rauvolfia Vomitoria + Hydrochlorothiazide, Lisinopril answer

Can you take Rehmannia with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.

Full Rehmannia + Hydrochlorothiazide, Lisinopril answer

Can you take Reishi Mushroom with Hydrochlorothiazide, Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Reishi Mushroom + Hydrochlorothiazide, Lisinopril answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Lisinopril is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Lisinopril, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Lisinopril sits in 10 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Lisinopril through this category.

Lisinopril 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrochlorothiazide, Lisinopril through this category.

About Hydrochlorothiazide, Lisinopril

Lisinopril and hydrochlorothiazide is a combination ACE inhibitor and diuretic (water pill) used to treat high blood pressure.

Generic name: Hydrochlorothiazide, Lisinopril  ·  Brand names: Zestoretic, Prinzide.

See the full Lisinopril and Hydrochlorothiazide drug information

Related: does Hydrochlorothiazide, Lisinopril deplete any nutrients?

Hydrochlorothiazide, Lisinopril has 18 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Lisinopril nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Lisinopril

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Lisinopril.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Lisinopril & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Lisinopril?
In our interaction database, 236 supplement and herbal ingredients have an interaction with Hydrochlorothiazide, Lisinopril on file — 10 rated major, 199 moderate, and 27 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Lisinopril supplement interactions are the most serious?
The 10 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Lisinopril?
That depends entirely on which supplement. The honest answer for Hydrochlorothiazide, Lisinopril is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zestoretic have the same supplement interactions as Hydrochlorothiazide, Lisinopril?
Yes — Zestoretic, Prinzide all contain Hydrochlorothiazide, Lisinopril, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Lisinopril deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Lisinopril has 18 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Lisinopril nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Lisinopril and my other medications?
This page covers Hydrochlorothiazide, Lisinopril against supplements and herbal ingredients. Checking Hydrochlorothiazide, Lisinopril against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lisinopril and Hydrochlorothiazide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.