Drug & supplement interaction

Acai + Hydrochlorothiazide, Lisinopril

Hydrochlorothiazide, Lisinopril brand names: Zestoretic, Prinzide.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Acai and Hydrochlorothiazide, Lisinopril in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Acai and Hydrochlorothiazide, Lisinopril

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide, Lisinopril and Acai in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Acai safety at a glance

Acai overall Use caution Acai is generally well tolerated as a food, but supplement quality and high-dose effects are not well studied.
Pregnancy Use caution Acai as a food is likely fine, but concentrated supplements have not been studied in pregnancy, so it is best to use caution.
Breastfeeding Use caution There is not enough safety information on acai supplements during breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide, Lisinopril and Acai? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Hydrochlorothiazide, Lisinopril

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hydrochlorothiazide, Lisinopril is filed under 10 classifications — including lisinopril, ace inhibitors (aceis), thiazide diuretics. Acai has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Hydrochlorothiazide, Lisinopril’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Acai Does Interact With Other Medications

Acai has 86 moderate known drug interactions in our database — Hydrochlorothiazide, Lisinopril isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Hydrochlorothiazide, Lisinopril)
Taking anything else?

Check Another of Your Medications Against Acai

Covers the 2,830 medications we’ve checked against Acai. Pick one to open its full report.

What to actually watch for

What Hydrochlorothiazide, Lisinopril’s Own FDA Label Lists

This is not an interaction — none of it involves Acai. These are the most notable effects listed in the ADVERSE REACTIONS section of Hydrochlorothiazide, Lisinopril’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Unsteadiness Worth acting on
  • A slow heartbeat Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on

Showing the 10 most notable of 76 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Lisinopril. Read the label on DailyMed › Where a percentage is shown, it is the share of 10,177 voluntary FDA FAERS reports for Hydrochlorothiazide, Lisinopril that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Acai’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Acai side to compare — that is a limit of the record, not a statement that Acai has no side effects.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Lisinopril

This page covers Acai only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Lisinopril page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Lisinopril page

“I would not add a supplement casually alongside hydrochlorothiazide and lisinopril (Zestoretic, Prinzide). This combination lowers blood pressure with a water pill plus an ACE inhibitor, and most interacting ingredients either drag pressure down too far or push back against the drug, while smaller groups strain the kidneys, drain potas…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Lisinopril interaction page

One more smart check

Taking Acai as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,313 real supplement products containing Acai, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Acai. Even though Acai itself has no known interaction with Hydrochlorothiazide, Lisinopril, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Acai and Hydrochlorothiazide, Lisinopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acai
Top 10%

#100 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Lisinopril
Top 25%

#690 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acai reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Acai and Hydrochlorothiazide, Lisinopril records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Acai

What is Acai?

Acai
  • Antioxidant support
  • Weight loss
  • Energy and vitality
  • Heart health
  • General wellness ('superfood')

Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often attached to acai supplements, including weight loss and disease prevention.

Euterpe oleracea · Arecaceae · Fruit (berry) and its pulp · Juice, frozen pulp, smoothie packs, powder, capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Acai is a good idea for someone in your situation. Here is what our Acai record says about it on its own.

Acai: dosing

There is no officially established or standardized dose for acai. Amounts used in studies and products vary widely depending on the form (juice, pulp, powder, or capsule).The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Acai monograph — the full record covers uses, side effects and every documented interaction.

Read the full Acai monograph & all interactions
Medication

About Lisinopril and Hydrochlorothiazide

What Is Lisinopril and Hydrochlorothiazide Used For?

Brand names: Zestoretic, Prinzide

Lisinopril and hydrochlorothiazide tablets — sold as the brand Zestoretic and as the generic combination — are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious cardiovascular events such as stroke and heart attack.

This is a fixed-dose combination product and is not intended as a first-line (initial) treatment for high blood pressure. It is typically prescribed for patients whose blood pressure is not adequately controlled on a single medication alone.

See full Lisinopril and Hydrochlorothiazide drug information
Keep checking

Other Drugs & Acai

Browse every other medication we’ve checked against Acai — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Acai page.

No interaction 2,743 drugs checked — show the list

We also checked Acai against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Acai list.

See the full Acai interactions page
See every supplement checked against Hydrochlorothiazide, Lisinopril, ranked by severity
Evidence & sources

Acai References

The 2 references that drive our Acai monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Acai and Hydrochlorothiazide, Lisinopril Together: Common Questions

Is it safe to take Acai with Hydrochlorothiazide, Lisinopril?
We do not list a known interaction between Acai and Hydrochlorothiazide, Lisinopril. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Acai and Hydrochlorothiazide, Lisinopril combination checked?
Interactions in our licensed database are recorded against drug classes. Hydrochlorothiazide, Lisinopril is filed under 10 classifications, and Acai has documented interactions with 1 drug class — none of Hydrochlorothiazide, Lisinopril's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Acai interact with any other medications?
Yes. Acai has 86 documented drug interactions in our database — Hydrochlorothiazide, Lisinopril is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Hydrochlorothiazide, Lisinopril interact with any supplements?
Yes. Hydrochlorothiazide, Lisinopril has documented interactions with 236 supplements in our database — Acai is not one of them. The Hydrochlorothiazide, Lisinopril interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Acai monograph Uses, safety profile, and every drug interaction in one place Lisinopril and Hydrochlorothiazide drug information The full plain-English guide to this medication Hydrochlorothiazide, Lisinopril supplement interactions Every supplement checked against Hydrochlorothiazide, Lisinopril, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide, Lisinopril and Acai?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.