Drug & supplement interaction

Beet + Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate brand name: Viread.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Beet and Tenofovir Disoproxil Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beet and Tenofovir Disoproxil Fumarate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tenofovir Disoproxil Fumarate and Beet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beet safety at a glance

Beet overall Generally safe Beet is widely eaten as a food and is generally well tolerated for most adults.
Pregnancy Use caution Beet as a food is fine, but concentrated supplements lack safety data, so use caution.
Breastfeeding Use caution Beet as a food is fine, but there is not enough data on concentrated supplements.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tenofovir Disoproxil Fumarate and Beet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tenofovir Disoproxil Fumarate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tenofovir Disoproxil Fumarate is filed under 4 classifications — including nucleoside reverse transcriptase inhibitors (nrtis), nephrotoxic drugs, oral drugs. Beet has documented interactions with 3 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), antihypertensive drugs (minor) and cytochrome p450 1a2 (cyp1a2) substrates (minor) — and none of Tenofovir Disoproxil Fumarate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Beet Does Interact With Other Medications

Beet has 645 moderate, 218 minor known drug interactions in our database — Tenofovir Disoproxil Fumarate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 645 Minor 218 No known interaction 1,967 (incl. Tenofovir Disoproxil Fumarate)
Taking anything else?

Check Another of Your Medications Against Beet

Covers the 2,830 medications we’ve checked against Beet. Pick one to open its full report.

What to actually watch for

What Beet Itself Has Been Linked To

This is not an interaction — nothing below involves Tenofovir Disoproxil Fumarate. It is the side-effect record for Beet on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Beet, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut / Anemia Worth acting on Additional detail

    “Orally, beet juice may cause red stools. This red coloring of the stools is not harmful. Additionally, beet supplementation has been reported to cause black stools. In one case, a 79-year-old male on apixaban and clopidogrel presented with black stools, nausea, and vomiting after taking beet pills 2-3 days prior.”

    Beet · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 94470. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
    2. 97726. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
    3. 100142. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
    4. 100145. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
    5. 105762. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
    6. 113426. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed
  • Kidney problems Worth acting on Additional detail

    “Orally, beet seems to be well tolerated when used for medicinal purposes, short term.

    Most Common Adverse Effects:

    Orally: Red stools and red urine.

    Serious Adverse Effects (Rare):

    Orally: Hypocalcemia and kidney damage when ingested in large amounts.”

    Beet · Natural Medicines adverse-effect record, reported in hypocalcemia.

  • Constipation / Diarrhea / Vomiting / Nausea Additional detail

    Recorded for Beet in the same Natural Medicines adverse-effect record shown under Bleeding in the gut / Anemia above.

Everything above comes from the Natural Medicines adverse-effect record for Beet — expand a row for the licensed statement it rests on. We haven’t matched Tenofovir Disoproxil Fumarate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tenofovir Disoproxil Fumarate.

Overlapping uses

What Tenofovir Disoproxil Fumarate Is Prescribed For, and What Beet Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tenofovir Disoproxil Fumarate is a prescription medicine with approved uses on its FDA label. Beet is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Beet has been studied for:

  • Liver disease studied, not established Beet has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Beet for liver disease

    Although there has been interest in using oral beet for liver disease, there is insufficient reliable information about the clinical effects of beet for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tenofovir Disoproxil Fumarate on your own; if you are taking Beet for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Tenofovir Disoproxil Fumarate

This page covers Beet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tenofovir Disoproxil Fumarate page lists 28 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Calcium (moderate).

By severity: 3 major · 15 moderate · 10 minor.

Open the Tenofovir Disoproxil Fumarate interaction page

One more smart check

Taking Beet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,786 real supplement products containing Beet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beet. Even though Beet itself has no known interaction with Tenofovir Disoproxil Fumarate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beet and Tenofovir Disoproxil Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beet
Top 5%

#39 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tenofovir Disoproxil Fumarate
Steady interest

#1,911 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Beet and Tenofovir Disoproxil Fumarate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beet

What is Beet?

Beet
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Beta vulgaris · Amaranthaceae · Root and leaves (greens) · Juice, powder, capsules, tablets, whole food, concentrated shots, gels

An interaction check asks whether these two react with each other — it does not ask whether Beet is a good idea for someone in your situation. Here is what our Beet record says about it on its own.

Beet: dosing

There is no official standardized dose of beet for supplement use. Studies have used a range of amounts of beetroot juice or powder, often based on nitrate content, but the best dose is not firmly established.If you choose a beet supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Beet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beet monograph & all interactions
Medication

About Tenofovir disoproxil fumarate/Tenofovir alafenamide

What Is Tenofovir disoproxil fumarate/Tenofovir alafenamide Used For?

Brand name: Viread

  • Tenofovir disoproxil fumarate (DF) (Viread) is used along with other medications to treat HIV infection in adults and children 2 years of age and older weighing 22 pounds (10 kilograms) or more. Tenofovir DF is also used to treat chronic (long term) HBV in adults and children 2 years of age and older weighing 22 pounds (10 kilograms) or more. Tenofovir alafenamide (AF) (Vemlidy) is used to treat chronic (long term) HBV in adults and children 12 years of age and older who have stable liver disease. Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV and HBV in the blood. Although tenofovir will not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. Tenofovir will not cure hepatitis B and may not prevent complications of chronic hepatitis B such as cirrhosis of the liver or liver cancer. Tenofovir may not prevent the spread of hepatitis B to other people.

See full Tenofovir disoproxil fumarate/Tenofovir alafenamide drug information
Keep checking

Other Drugs & Beet

Browse every other medication we’ve checked against Beet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
645Moderate
218Minor
1,966No known interaction
645 Moderate 218 Minor 1,966 No interaction
Moderate

645 interactions

Showing 60 of 645 moderate interactions — see all 645 on the Beet page.

Minor

218 interactions

Showing 60 of 218 minor interactions — see all 218 on the Beet page.

No interaction 1,966 drugs checked — show the list

We also checked Beet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,966 medications checked with no known interaction — see the full Beet list.

See the full Beet interactions page
See every supplement checked against Tenofovir Disoproxil Fumarate, ranked by severity
Evidence & sources

Beet References

The 10 references that drive our Beet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  3. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  4. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  5. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  6. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  7. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  8. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  9. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  10. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beet and Tenofovir Disoproxil Fumarate Together: Common Questions

Is it safe to take Beet with Tenofovir Disoproxil Fumarate?
We do not list a known interaction between Beet and Tenofovir Disoproxil Fumarate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Beet and Tenofovir Disoproxil Fumarate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Beet in each. That is a conversation for your prescriber, especially if Tenofovir Disoproxil Fumarate is being adjusted to a target.
How was the Beet and Tenofovir Disoproxil Fumarate combination checked?
Interactions in our licensed database are recorded against drug classes. Tenofovir Disoproxil Fumarate is filed under 4 classifications, and Beet has documented interactions with 3 drug classes — none of Tenofovir Disoproxil Fumarate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Beet interact with any other medications?
Yes. Beet has 863 documented drug interactions in our database — Tenofovir Disoproxil Fumarate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tenofovir Disoproxil Fumarate interact with any supplements?
Yes. Tenofovir Disoproxil Fumarate has documented interactions with 28 supplements in our database — Beet is not one of them. The Tenofovir Disoproxil Fumarate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Beet monograph Uses, safety profile, and every drug interaction in one place Tenofovir disoproxil fumarate/Tenofovir alafenamide drug information The full plain-English guide to this medication Tenofovir Disoproxil Fumarate supplement interactions Every supplement checked against Tenofovir Disoproxil Fumarate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tenofovir Disoproxil Fumarate and Beet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.