Drug & supplement interaction

Bifidobacterium Bifidum + Pyrazinamide

Pyrazinamide brand name: Tebrazid.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Bifidobacterium Bifidum has a moderate interaction with Pyrazinamide. Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Bifidobacterium Bifidum and Pyrazinamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Pyrazinamide

Pyrazinamide falls under ANTIBIOTIC DRUGS — the group Bifidobacterium Bifidum interacts with.

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the key thing to understand: this interaction runs in one direction, and it's the probiotic that takes the hit, not your TB treatment. Pyrazinamide is an antibiotic, and antibiotics don't tell the difference between harmful germs and the helpful live bacteria in a Bifidobacterium bifidum supplement. So if you swallow them at the same time, the drug may kill off a good chunk of those friendly organisms before they can do their job.

The good news is your pyrazinamide keeps working just fine, and your TB therapy is not weakened by the probiotic. To get more value from the supplement, a simple fix is to space them out by at least 2 hours. This is a theoretical, common-sense concern, not a dangerous one. Still, run your full regimen by your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bifidobacterium Bifidum Also Interacts With Other Medications

Bifidobacterium Bifidum has 181 moderate known drug interactions in our database — the Pyrazinamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Pyrazinamide)
Taking anything else?

Check Another of Your Medications Against Bifidobacterium Bifidum

Covers the 2,830 medications we’ve checked against Bifidobacterium Bifidum. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pyrazinamide

This page covers Bifidobacterium Bifidum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pyrazinamide page lists 102 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Alfalfa (moderate).

By severity: 4 major · 86 moderate · 12 minor.

From our pharmacist’s overview on the Pyrazinamide page

“Pyrazinamide is one of the core tuberculosis drugs, and because treatment runs for months while the liver already carries the drug's own strain, the 102 supplements and herbs on file here warrant real caution. Thirty-eight of them add their own liver stress, and three of the four major-rated entries sit in that group, including somethi…”

Reviewed by 2 · Jul 18, 2026

Open the Pyrazinamide interaction page

One more smart check

Taking Bifidobacterium Bifidum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,041 real supplement products containing Bifidobacterium Bifidum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bifidobacterium Bifidum. Your product may carry other ingredients that interact with Pyrazinamide too, on top of Bifidobacterium Bifidum — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bifidobacterium Bifidum and Pyrazinamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bifidobacterium Bifidum
Top 10%

#104 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pyrazinamide
Top half

#1,111 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bifidobacterium Bifidum

What is Bifidobacterium Bifidum?

  • Digestive health and regularity
  • Diarrhea (including antibiotic-related)
  • Irritable bowel syndrome (IBS) symptoms
  • Supporting gut and immune balance
  • Infant gut health

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may help with certain types of diarrhea and digestive discomfort, but results vary by strain and condition. It is generally well tolerated in healthy people, but anyone who is seriously ill or has a weakened immune system should check with a doctor first.

Read the full Bifidobacterium Bifidum monograph & all interactions
Medication

About Pyrazinamide

What Is Pyrazinamide Used For?

Brand name: Tebrazid

Pyrazinamide tablets are used to treat active tuberculosis (TB) in adults and children. It is always used in combination with other anti-TB medicines — never alone. The standard CDC-recommended approach uses pyrazinamide as part of a 6-month regimen, typically for the first 2 months.

It is also used when initial TB treatment with other drugs has failed. People with drug-resistant TB or with HIV infection may need a treatment plan specifically tailored to their situation, which can include pyrazinamide as a key part of the regimen.

See full Pyrazinamide drug information
Keep checking

Other Drugs & Bifidobacterium Bifidum

Browse every other medication we’ve checked against Bifidobacterium Bifidum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Bifidobacterium Bifidum page.

No interaction 2,648 drugs checked — show the list

We also checked Bifidobacterium Bifidum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Bifidobacterium Bifidum list.

See the full Bifidobacterium Bifidum interactions page
See every supplement checked against Pyrazinamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bifidobacterium Bifidum monograph › Uses, safety, and every drug interaction in one place Pyrazinamide supplement interactions › Every supplement checked against Pyrazinamide, ranked by severity Pyrazinamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bifidobacterium Bifidum and Pyrazinamide Together: Common Questions

Can you take Bifidobacterium Bifidum with Pyrazinamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bifidobacterium Bifidum and Pyrazinamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pyrazinamide and Bifidobacterium Bifidum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.