Drug & supplement interaction

Bishop's Weed + Diclofenac

Diclofenac brand name: Zorvolex.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Diclofenac falls into 2 drug categories that Bishop's Weed can interact with; the most serious is rated moderate. Bishop's weed constituents seem to cause photosensitivity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Bishop's Weed and Diclofenac

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Bishop's Weed interacts with whole categories of medication. Diclofenac falls into 2 of those categories, so it can interact with Bishop's Weed in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

PHOTOSENSITIZING DRUGS

1 of 2

Why this applies to Diclofenac

Diclofenac falls under PHOTOSENSITIZING DRUGS — the group Bishop's Weed interacts with.

Bishop's weed constituents seem to cause photosensitivity. Theoretically, concomitant use of bishop's weed with photosensitizing drugs might result in increased photosensitivity.
Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the deal with combining Bishop's Weed and diclofenac. Diclofenac is an anti-inflammatory pain reliever, and one of its lesser-known quirks is that it can make your skin more sensitive to sunlight on its own. Bishop's Weed contains psoralens, natural compounds that also ramp up sun sensitivity. So putting the two together could, in theory, stack that effect.

What might that look like? Faster or more intense sunburn, redness, or a rash on skin that gets sun exposure, even after a short time outdoors. I'll be honest, this is based mostly on anecdotal reports, not strong studies, so don't panic. Just be smart about sunscreen and covering up, and check with your pharmacist or doctor before using Bishop's Weed at all, since the plant itself can be risky.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80.
  2. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

2 of 2

Diclofenac also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.

Bergapten, a constituent of bishop's weed, has antiplatelet activity. Theoretically, bishop's weed might have additive effects with anticoagulant or antiplatelet drugs and possibly increase the risk of bleeding.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with pairing Bishop's Weed and diclofenac. One compound in Bishop's Weed (bergapten) appears to have a mild blood-thinning, anti-platelet effect. Diclofenac is an NSAID, and these pain relievers already nudge your bleeding risk up a little on their own. So the worry is that the two together could add up and make you bruise or bleed more easily than expected.

I want to be honest about how solid this is: it's theoretical, based on how these substances work in the lab, not on real patient reports. Still, watch for warning signs like easy bruising, nosebleeds, dark or tarry stools, or stomach upset, since diclofenac can irritate the stomach. Bishop's Weed isn't safe to self-dose anyway, so please loop in your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bishop's Weed Also Interacts With Other Medications

Bishop's Weed has 953 moderate known drug interactions in our database — the Diclofenac one above is among them. If you take anything else, check it against the full list below.

Moderate 953 No known interaction 1,877 (incl. Diclofenac)
Taking anything else?

Check Another of Your Medications Against Bishop's Weed

Covers the 2,830 medications we’ve checked against Bishop's Weed. Pick one to open its full report.

From our Q&A

Questions About Bishop's Weed or Diclofenac

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bishop's Weed or Diclofenac, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac

This page covers Bishop's Weed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac page lists 306 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 265 moderate · 34 minor.

From our pharmacist’s overview on the Diclofenac page

“Diclofenac (Zorvolex) is an NSAID pain reliever that already stresses the stomach lining and kidneys on its own, so treat this list as a real safety issue, not fine print. Two thirds of the 306 supplements on file can thin the blood or slow clotting, and stacked on an NSAID that raises the odds of stomach bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac interaction page

One more smart check

Taking Bishop's Weed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 83 real supplement products containing Bishop's Weed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bishop's Weed. Your product may carry other ingredients that interact with Diclofenac too, on top of Bishop's Weed — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bishop's Weed and Diclofenac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bishop's Weed
Top 25%

#303 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac
Top 25%

#398 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bishop's Weed

What is Bishop's Weed?

Bishop's Weed
  • Vitiligo (loss of skin color)
  • Psoriasis
  • Digestive complaints
  • Asthma and breathing problems
  • Kidney stones
  • Diuretic (increasing urine)

Bishop's Weed (Ammi majus) is a flowering plant whose seeds contain natural light-sensitizing compounds called psoralens, which have been studied mainly for skin conditions like vitiligo and psoriasis when combined with light therapy. The plant is potentially toxic and can cause severe skin and eye reactions when exposed to sunlight, so it is not something to take on your own. If you are interested in psoralen-based treatments, work with a dermatologist rather than self-treating.

Read the full Bishop's Weed monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand name: Zorvolex

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

See full Diclofenac drug information
Keep checking

Other Drugs & Bishop's Weed

Browse every other medication we’ve checked against Bishop's Weed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
953Moderate
0Minor
1,876No known interaction
953 Moderate 1,876 No interaction
Moderate

953 interactions

Showing 60 of 953 moderate interactions — see all 953 on the Bishop's Weed page.

No interaction 1,876 drugs checked — show the list

We also checked Bishop's Weed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,876 medications checked with no known interaction — see the full Bishop's Weed list.

See the full Bishop's Weed interactions page
See every supplement checked against Diclofenac, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bishop's Weed monograph › Uses, safety, and every drug interaction in one place Diclofenac supplement interactions › Every supplement checked against Diclofenac, ranked by severity Diclofenac drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bishop's Weed and Diclofenac Together: Common Questions

Can you take Bishop's Weed with Diclofenac?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Bishop's Weed and Diclofenac?
Diclofenac belongs to more than one drug category, and Bishop's Weed interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Bishop's Weed and Diclofenac interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Diclofenac and Bishop's Weed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.