Black Currant - Isopropamide, Trifluoperazine Interaction
Herbal: Black Currant
Also Known As: Ribes nigrum, Black Currant Seed Oil, Cassis, European Black Currant, Groseille Noir, Grosella Negra, Kurokarin, Nabar, Paper, Ribes Nigri Folium (black currant leaf), Ribes Nero
Drug: Isopropamide, Trifluoperazine
Brand names:
Stelabid No 1, Stelabid No 2, Stelabid Forte
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Isopropamide, Trifluoperazine is classified as belonging to the following category: Phenothiazines
Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
- Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379.
- Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3.
Black Currant Overview
Black currant (Ribes nigrum) is a shrub native to Europe and parts of Asia. It produces small, edible berries known for their sweet-tart flavor and deep purple color. They are often used in a variety of culinary applications and are a popular flavoring agent.
Black currants are a good source of vitamin C, dietary fiber, and several other nutrients. They are also believed to have various health benefits, including boosting the immune system, improving cardiovascular health, and reducing inflammation.
In addition to the whole fruit, black currant seeds are often utilized for dietary supplements and are sometimes marketed as 'black currant seed oil', which contain a high amount of GLA (Gamma-linolenic acid), an omega-6 fatty acid.
Black Currant - More Interactions
Black Currant interacts with 139 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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