Drug & supplement interaction

Black Mulberry + Benztropine

Benztropine brand names: Cogentin, Cogentin Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Black Mulberry and Benztropine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Black Mulberry and Benztropine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Benztropine and Black Mulberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Mulberry safety at a glance

Black Mulberry overall Use caution The fruit is safe as food, but concentrated supplement doses are less studied.
Pregnancy Use caution Eating the fruit as food is likely fine, but avoid concentrated extracts unless your doctor approves.
Breastfeeding Use caution Fruit as food is likely fine, but there is little safety data on supplement doses.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Benztropine and Black Mulberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Benztropine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Benztropine is filed under 2 classifications — anticholinergic drugs, oral drugs. Black Mulberry has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and midazolam (versed) (moderate) — and none of Benztropine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Mulberry Does Interact With Other Medications

Black Mulberry has 87 moderate known drug interactions in our database — Benztropine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Benztropine)
Taking anything else?

Check Another of Your Medications Against Black Mulberry

Covers the 2,830 medications we’ve checked against Black Mulberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Black Mulberry and Benztropine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Black Mulberry

    “Topically, black mulberry leaf may cause contact dermatitis. A case of lichenoid contact dermatitis was reported in a 68-year-old male who came into contact with black mulberry leaves while picking black mulberries.”

    Black Mulberry · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 105799. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

    Benztropine

    Listed in the ADVERSE REACTIONS section of the FDA label for Benztropine. Read the label on DailyMed ›

Effects for Benztropine come from the ADVERSE REACTIONS section of its FDA label; effects for Black Mulberry come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Benztropine

This page covers Black Mulberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Benztropine page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Benztropine page

“People usually take benztropine (Cogentin) for Parkinson's tremor or for the stiffness and restlessness antipsychotic drugs can cause, and this is a supplement list to approach with genuine care. Three of its 46 interactions rate major: activated charcoal, which can soak the drug up in the gut before it works, and two alkaloid herbs, h…”

Reviewed by 2 · Jul 18, 2026

Open the Benztropine interaction page

How much people look this up

Where Black Mulberry and Benztropine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Mulberry
Top half

#717 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Benztropine
Top half

#1,296 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Mulberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Mulberry and Benztropine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Mulberry

What is Black Mulberry?

Black Mulberry
  • General antioxidant support
  • Blood sugar support
  • Cholesterol and heart health
  • Digestive health
  • Cold and sore throat remedies (traditional)

Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for blood sugar and cholesterol, but the evidence is still limited. Talk with your pharmacist or doctor before using concentrated extracts, especially if you have a health condition.

Morus nigra · Moraceae · Fruit (berries), leaves, and sometimes root bark · Fresh or dried fruit, juice, jam, tea, powder, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Black Mulberry is a good idea for someone in your situation. Here is what our Black Mulberry record says about it on its own.

Black Mulberry: dosing

There is no official standardized dose for black mulberry supplements. The amount in products varies widely depending on whether the fruit, leaf, or an extract is used.If you use a commercial product, follow the directions on the label and do not take more than recommended. Eating the fresh or dried fruit as part of a normal diet does not require special dosing.

From our Black Mulberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Mulberry monograph & all interactions
Medication

About Benztropine

What Is Benztropine Used For?

Brand names: Cogentin, Cogentin Injection

Benztropine mesylate is used as part of the treatment for all forms of parkinsonism — a group of conditions that cause tremors, stiffness, and slowness of movement. It is not a cure, but it helps ease symptoms when used alongside other therapies.

It is also used to control extrapyramidal disorders (abnormal, involuntary muscle movements and stiffness) that can be caused by antipsychotic drugs such as phenothiazines. It is not used for tardive dyskinesia (uncontrolled muscle movements that develop after long-term use of certain psychiatric drugs).

See full Benztropine drug information
Keep checking

Other Drugs & Black Mulberry

Browse every other medication we’ve checked against Black Mulberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Black Mulberry page.

No interaction 2,742 drugs checked — show the list

We also checked Black Mulberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Black Mulberry list.

See the full Black Mulberry interactions page
See every supplement checked against Benztropine, ranked by severity
Evidence & sources

Black Mulberry References

The 5 references that drive our Black Mulberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. PubMed
  3. Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. PubMed
  4. Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silic
  5. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Mulberry and Benztropine Together: Common Questions

Is it safe to take Black Mulberry with Benztropine?
We do not list a known interaction between Black Mulberry and Benztropine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Black Mulberry and Benztropine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Black Mulberry and Benztropine combination checked?
Interactions in our licensed database are recorded against drug classes. Benztropine is filed under 2 classifications, and Black Mulberry has documented interactions with 2 drug classes — none of Benztropine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Black Mulberry interact with any other medications?
Yes. Black Mulberry has 87 documented drug interactions in our database — Benztropine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Benztropine interact with any supplements?
Yes. Benztropine has documented interactions with 46 supplements in our database — Black Mulberry is not one of them. The Benztropine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Mulberry monograph Uses, safety profile, and every drug interaction in one place Benztropine drug information The full plain-English guide to this medication Benztropine supplement interactions Every supplement checked against Benztropine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Benztropine and Black Mulberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.