Boswellia Serrata + Diazepam
Diazepam brand names: Valium, Valium injection, Diastat AcuDial, Valtoco.
Diazepam falls into 4 drug categories that Boswellia Serrata can interact with; the most serious is rated moderate. Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
Read the full interaction reportBoswellia Serrata and Diazepam
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Boswellia Serrata interacts with whole categories of medication. Diazepam falls into 4 of those categories, so it can interact with Boswellia Serrata in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
1 of 4Why this applies to Diazepam
Diazepam falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group Boswellia Serrata interacts with.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the quick picture with Valium (diazepam) and boswellia. Your liver uses an enzyme called CYP2C19 to help break diazepam down. Lab studies hint that boswellic acids (the active part of boswellia) may slow that enzyme a bit. If that happens in real life, diazepam could clear more slowly and build up, nudging up its calming effects.
For diazepam that would mean more drowsiness, dizziness, grogginess, or feeling unsteady. I want to be honest though: this is theoretical, based only on test-tube work, not on people taking them together, so the real-world risk is likely small. Still, if you notice extra sleepiness or feel off, mention it to your pharmacist or doctor before changing anything.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
2 of 4Diazepam also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for Valium (diazepam). Lab studies hint that boswellic acids may slow down a liver enzyme called CYP1A2, which is one of the pathways that helps clear diazepam from your body. If that pathway is partly blocked, diazepam could linger a bit longer, and theoretically you might feel its calming effects more strongly. With diazepam that could mean extra drowsiness, dizziness, foggy thinking, or feeling unsteady on your feet.
I want to be honest about how soft this evidence is. It comes only from test-tube research, not real people, so it's a 'could happen' situation rather than a proven one. Many folks take both with no trouble. Still, if you notice you feel groggier than usual, mention it to your pharmacist or doctor before changing anything.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 4Diazepam also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. Your body uses a liver enzyme called CYP2C9 to help clear diazepam (Valium). Lab studies suggest boswellic acids from Boswellia serrata may slow that enzyme down a bit. If that happens in real life, diazepam could build up a little more than usual, which might mean stronger sedation, drowsiness, dizziness, or feeling foggy or unsteady on your feet.
I want to be honest with you though: this is only a theoretical concern based on test-tube research, not on actual patient cases, so the real-world effect may be small or none. Still, since both can be calming, it's worth a quick chat with your pharmacist or doctor before combining them, especially if you already feel groggy on your dose. Don't change anything on your own.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
4 of 4Diazepam also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the situation with Valium (diazepam) and boswellia. Your liver uses an enzyme called CYP3A4 to help break down diazepam. In lab dish studies, boswellic acids appear to slow that same enzyme down (and at low amounts may slightly speed it up). If boswellia blocks CYP3A4 in your body, diazepam could clear a bit more slowly and build up, which might mean more drowsiness, dizziness, grogginess, or feeling unsteady on your feet.
I want to be honest with you: this is theoretical, based only on test-tube research, not real people. Diazepam isn't a prodrug, so it doesn't flip the other way. For most folks this likely won't cause trouble, but if you notice extra sleepiness, check in with your pharmacist or doctor before changing anything.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Boswellia Serrata Also Interacts With Other Medications
Boswellia Serrata has 951 moderate known drug interactions in our database — the Diazepam one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Boswellia Serrata
We haven’t checked that one against Boswellia Serrata yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Boswellia Serrata. Pick one to open its full report.
Questions About Boswellia Serrata or Diazepam
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Boswellia Serrata or Diazepam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Inquiring About Extended-Release Diazepam ›
- Is Brand Name Valium Still Available? ›
- Can Klonopin (Clonazepam) Cause Erectile Dysfunction? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Diazepam
This page covers Boswellia Serrata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diazepam page lists 244 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).
By severity: 9 major · 191 moderate · 44 minor.
Taking Boswellia Serrata as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,914 real supplement products containing Boswellia Serrata, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Boswellia Serrata. Your product may carry other ingredients that interact with Diazepam too, on top of Boswellia Serrata — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Boswellia Serrata and Diazepam Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#92 of 1,452 supplements looked up here in the last 7 days
#100 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Boswellia Serrata
What is Boswellia Serrata?
- Osteoarthritis joint pain
- Rheumatoid arthritis
- Inflammation
- Asthma
- Inflammatory bowel conditions
Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidence is limited and more research is needed. It is generally well tolerated, but you should check with your pharmacist or doctor before using it, especially during pregnancy or breastfeeding.
About Diazepam
What Is Diazepam Used For?
Brand names: Valium, Valium injection, Diastat AcuDial, Valtoco
-
Diazepam is used to relieve anxiety and to control agitation caused by alcohol withdrawal. It is also used along with other medications to control muscle spasms and spasticity caused by certain neurological disorders such as cerebral palsy (condition that causes difficulty with movement and balance), paraplegia (inability to move parts of the body), athetosis (abnormal muscle contractions), and stiff-man syndrome (a rare disorder with muscle rigidity and stiffness). Diazepam is also used along with other medications to control seizures. Diazepam is in a class of medications called benzodiazepines. It works by calming abnormal overactivity in the brain.
Other Drugs & Boswellia Serrata
Browse every other medication we’ve checked against Boswellia Serrata — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
951 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Meloxicam ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Bendamustine ›
Showing 60 of 951 moderate interactions — see all 951 on the Boswellia Serrata page.
No interaction 1,878 drugs checked — show the list
We also checked Boswellia Serrata against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Aspirin ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Levetiracetam ›
- Spironolactone ›
- Factor 7a ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Minoxidil ›
- Mitomycin ›
- Levodopa ›
- Ezetimibe ›
- Phentermine, Topiramate ›
- Cefaclor ›
- Lenvatinib ›
- Phenylephrine ›
- Vancomycin ›
- Hethylphenidate Hcl ›
- Dirithromycin ›
- Bentoquatam ›
- Pentobarbitone ›
- Amoxicillin, Clavulanate Potassium ›
- Procainamide ›
- Hydroxychloroquine ›
- Tenecteplase ›
Showing the 60 most looked-up of 1,878 medications checked with no known interaction — see the full Boswellia Serrata list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diazepam Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diazepam as a medicine that can lower these. This is not an interaction with Boswellia Serrata — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diazepam nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Boswellia Serrata and Diazepam Together: Common Questions
Can you take Boswellia Serrata with Diazepam?
Why are there 4 interactions listed for Boswellia Serrata and Diazepam?
How serious is the Boswellia Serrata and Diazepam interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Diazepam and Boswellia Serrata?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.