Drug & supplement interaction

Canadian Hemp + Conjugated Estrogens, Meprobamate

Conjugated Estrogens, Meprobamate brand names: PMB 200, PMB 400.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Canadian Hemp and Conjugated Estrogens, Meprobamate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Canadian Hemp and Conjugated Estrogens, Meprobamate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Conjugated Estrogens, Meprobamate and Canadian Hemp in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Canadian Hemp safety at a glance

Canadian Hemp overall Avoid It contains toxic cardiac glycosides and is considered a poisonous plant, not a safe supplement.
Pregnancy Likely Unsafe When used orally due to the toxic potential of its cardiac glycoside constituents; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally due to the toxic potential of its cardiac glycoside constituents; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Conjugated Estrogens, Meprobamate and Canadian Hemp? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Conjugated Estrogens, Meprobamate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Conjugated Estrogens, Meprobamate is filed under 6 classifications — including ethinyl estradiol, estrogens, glucuronidated drugs. Canadian Hemp has documented interactions with 2 drug classes — the most serious being digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Conjugated Estrogens, Meprobamate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Canadian Hemp Does Interact With Other Medications

Canadian Hemp has 76 moderate known drug interactions in our database — Conjugated Estrogens, Meprobamate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 76 No known interaction 2,754 (incl. Conjugated Estrogens, Meprobamate)
Taking anything else?

Check Another of Your Medications Against Canadian Hemp

Covers the 2,830 medications we’ve checked against Canadian Hemp. Pick one to open its full report.

What to actually watch for

What Canadian Hemp Itself Has Been Linked To

This is not an interaction — nothing below involves Conjugated Estrogens, Meprobamate. It is the side-effect record for Canadian Hemp on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Canadian Hemp, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A slow heartbeat / Raised blood pressure Worth acting on Additional detail

    “Orally, Canadian hemp can cause digitalis-like toxicity due to its cardiac glycoside constituents. Symptoms of toxicity can include bradycardia with hypotension, increased heart contractions, and reflex hypertension. Canadian hemp can also cause topical irritation of the gastrointestinal mucous membranes.”

    Canadian Hemp · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, Canadian hemp might cause bradycardia with low blood pressure, increased heart contractions, and reflex hypertension (18).”

    Canadian Hemp · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Low blood pressure Additional detail

    Recorded for Canadian Hemp in the same Natural Medicines adverse-effect record shown under A slow heartbeat / Raised blood pressure above.

  • Vomiting / Nausea Additional detail

    “Orally, Canadian hemp can cause topical irritation of the gastrointestinal mucous membranes. This irritation can result in a higher incidence of nausea and vomiting than with other cardiac glycoside-containing plants (such as digitalis) (18).”

    Canadian Hemp · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Canadian Hemp — expand a row for the licensed statement it rests on. We haven’t matched Conjugated Estrogens, Meprobamate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Conjugated Estrogens, Meprobamate.

Special populations

Canadian Hemp in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally due to the toxic potential of its cardiac glycoside constituents; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Conjugated Estrogens, Meprobamate

This page covers Canadian Hemp only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Conjugated Estrogens, Meprobamate page lists 187 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 152 moderate · 32 minor.

From our pharmacist’s overview on the Conjugated Estrogens, Meprobamate page

“If you take conjugated estrogens with meprobamate (PMB), a combination that pairs hormone replacement with a sedative, treat this list as a real safety check, not background noise. Three of the 187 entries on file rate major, and they pull in different directions.”

Reviewed by 2 · Jul 18, 2026

Open the Conjugated Estrogens, Meprobamate interaction page

How much people look this up

Where Canadian Hemp and Conjugated Estrogens, Meprobamate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Canadian Hemp
Top half

#389 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Conjugated Estrogens, Meprobamate
Top half

#1,248 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Canadian Hemp reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Canadian Hemp and Conjugated Estrogens, Meprobamate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Canadian Hemp

What is Canadian Hemp?

  • Heart-related swelling (dropsy/edema)
  • Fluid retention
  • Constipation
  • Urinary problems
  • Traditional folk remedy uses

Canadian Hemp (Apocynum cannabinum) is a toxic North American plant historically used as a heart stimulant and diuretic, but it contains potent cardiac glycosides that can cause dangerous heart and poisoning effects. It is not a safe or recommended dietary supplement, and there is no reliable modern evidence supporting its use. Avoid using it and talk to a pharmacist or doctor about safer, proven options.

Apocynum cannabinum · Apocynaceae · Dried roots and rhizomes · Tincture, dried root, traditional decoction (rarely sold as a modern supplement)

An interaction check asks whether these two react with each other — it does not ask whether Canadian Hemp is a good idea for someone in your situation. Here is what our Canadian Hemp record says about it on its own.

Canadian Hemp: dosing

There is no established safe dose for Canadian Hemp, and we do not provide one. Because it contains potent and potentially deadly heart-acting compounds with a very narrow safety margin, no general dosing guidance can be given.If you come across a product containing Apocynum cannabinum, do not take it without speaking to a pharmacist or doctor first. In nearly all cases, safer and better-studied options are available.

From our Canadian Hemp monograph — the full record covers uses, side effects and every documented interaction.

Read the full Canadian Hemp monograph & all interactions
Keep checking

Other Drugs & Canadian Hemp

Browse every other medication we’ve checked against Canadian Hemp — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
76Moderate
0Minor
2,753No known interaction
76 Moderate 2,753 No interaction
Moderate

76 interactions

Showing 60 of 76 moderate interactions — see all 76 on the Canadian Hemp page.

No interaction 2,753 drugs checked — show the list

We also checked Canadian Hemp against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,753 medications checked with no known interaction — see the full Canadian Hemp list.

See the full Canadian Hemp interactions page
See every supplement checked against Conjugated Estrogens, Meprobamate, ranked by severity
Evidence & sources

Canadian Hemp References

The 2 references that drive our Canadian Hemp monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Canadian Hemp and Conjugated Estrogens, Meprobamate Together: Common Questions

Is it safe to take Canadian Hemp with Conjugated Estrogens, Meprobamate?
We do not list a known interaction between Canadian Hemp and Conjugated Estrogens, Meprobamate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Canadian Hemp and Conjugated Estrogens, Meprobamate combination checked?
Interactions in our licensed database are recorded against drug classes. Conjugated Estrogens, Meprobamate is filed under 6 classifications, and Canadian Hemp has documented interactions with 2 drug classes — none of Conjugated Estrogens, Meprobamate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Canadian Hemp interact with any other medications?
Yes. Canadian Hemp has 76 documented drug interactions in our database — Conjugated Estrogens, Meprobamate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Conjugated Estrogens, Meprobamate interact with any supplements?
Yes. Conjugated Estrogens, Meprobamate has documented interactions with 187 supplements in our database — Canadian Hemp is not one of them. The Conjugated Estrogens, Meprobamate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Canadian Hemp monograph Uses, safety profile, and every drug interaction in one place Conjugated Estrogens, Meprobamate supplement interactions Every supplement checked against Conjugated Estrogens, Meprobamate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Conjugated Estrogens, Meprobamate and Canadian Hemp?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.