Drug & supplement interaction

Caprylic Acid + Tafenoquine

Tafenoquine brand names: Krintafel, Arakoda.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Caprylic Acid and Tafenoquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tafenoquine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Caprylic Acid and Tafenoquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tafenoquine and Caprylic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Caprylic Acid safety at a glance

Caprylic Acid overall Use caution Generally recognized as safe in food, but supplement doses are less well studied.
Pregnancy Use caution Food amounts are likely fine, but supplement doses lack safety data, so avoid unless your doctor approves.
Breastfeeding Use caution Caprylic acid occurs naturally in breast milk, but concentrated supplement safety is unknown, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tafenoquine and Caprylic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tafenoquine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tafenoquine is filed under a single classification — oral drugs. Caprylic Acid has documented interactions with 3 drug classes — the most serious being antihypertensive drugs (moderate), nonsteroidal anti-inflammatory drugs (nsaids) (moderate) and warfarin (coumadin) (moderate) — and none of Tafenoquine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Caprylic Acid Does Interact With Other Medications

Caprylic Acid has 262 moderate known drug interactions in our database — Tafenoquine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 262 No known interaction 2,568 (incl. Tafenoquine)
Taking anything else?

Check Another of Your Medications Against Caprylic Acid

Covers the 2,830 medications we’ve checked against Caprylic Acid. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Caprylic Acid and Tafenoquine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache / Dizziness reported in 15.7% of FDA reports for Tafenoquine Additional detail

    Caprylic Acid

    “Orally, caprylic acid has rarely been reported to cause mild dizziness, headache, and fatigue.”

    Caprylic Acid · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 97662. Voller B, Lines E, McCrossin G, et al. Dose-escalation study of octanoic acid in patients with essential tremor. J Clin Invest. 2016;126(4):1451-7. PubMed

    Tafenoquine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tafenoquine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Caprylic Acid but not commonly for Tafenoquine: stomach upset, a change in taste and tiredness.

Effects for Tafenoquine come from the ADVERSE REACTIONS section of its FDA label; effects for Caprylic Acid come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 70 voluntary FDA FAERS reports for Tafenoquine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Tafenoquine Products Have a Food Rule — Caprylic Acid Should Not Break It

At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Caprylic Acid on an empty stomach out of habit, keep them separate — and take Tafenoquine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tafenoquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Regimen Name Timing Dosage Loading regimen For each of the 3 days before travel to a malarious area 200 mg (2 of the 100 mg tablets) once daily for 3 days Maintenance regimen While in the malarious area 200 mg (2 of the 100 mg tablets) once weekly – start 7 days after the last loading regimen dose Terminal prophylaxis regimen In the week following exit from the malarious area 200 mg (2 of

From the Dosage and Administration section of the FDA label we read for Tafenoquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tafenoquine

This page covers Caprylic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tafenoquine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Tafenoquine page

“Tafenoquine (Krintafel, Arakoda) protects against malaria, including the relapsing kind that hides in the liver, and every supplement known to interact with it threatens the same thing, how much of the pill actually reaches your blood. That deserves genuine care, since a partly absorbed antimalarial can let parasites survive and resurf…”

Reviewed by 2 · Jul 18, 2026

Open the Tafenoquine interaction page

One more smart check

Taking Caprylic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 514 real supplement products containing Caprylic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Caprylic Acid. Even though Caprylic Acid itself has no known interaction with Tafenoquine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Caprylic Acid and Tafenoquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Caprylic Acid
Top 25%

#336 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tafenoquine
Steady interest

#2,651 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Caprylic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Caprylic Acid and Tafenoquine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Caprylic Acid

What is Caprylic Acid?

Caprylic Acid
  • Candida and yeast overgrowth
  • Gut health support
  • Antimicrobial
  • Digestive health
  • Part of ketogenic diets

Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While laboratory studies show it has antimicrobial activity, strong human evidence for most supplement claims is limited. It is generally considered safe in food amounts, but talk with your pharmacist or doctor before using concentrated supplements.

Fatty acid derived from coconut and palm kernel oil; also found in milk fat · Capsules, softgels, liquid oil, part of MCT oil blends

An interaction check asks whether these two react with each other — it does not ask whether Caprylic Acid is a good idea for someone in your situation. Here is what our Caprylic Acid record says about it on its own.

Caprylic Acid: dosing

There is no official, well-established dose for caprylic acid as a supplement. Products vary widely in strength and form, so the right amount depends on the specific product.The safest approach is to follow the directions on the product label and start with a lower amount to see how your body responds.

From our Caprylic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Caprylic Acid monograph & all interactions
Medication

About Tafenoquine

What Is Tafenoquine Used For?

Brand names: Krintafel, Arakoda

Tafenoquine is used for two distinct purposes depending on the product. Arakoda and Kodatef are used for malaria prophylaxis — that is, preventing malaria in adults 18 and older who are traveling to or living in areas where malaria is present.

Krintafel is used for the radical cure of Plasmodium vivax malaria — meaning it prevents the malaria parasite from coming back (relapsing) in patients 16 and older who are already being treated with chloroquine for an active P. vivax infection. Krintafel is not used to treat an active malaria attack on its own, and it should only be used alongside chloroquine, not other antimalarials.

Most-Reported Side Effects for Tafenoquine

From FAERS, the FDA’s public side-effect reporting system (70 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 20 reports
Anxiety 18 reports
Post-traumatic stress disorder 15 reports
Anger 14 reports
Nausea 14 reports
See full Tafenoquine drug information
Keep checking

Other Drugs & Caprylic Acid

Browse every other medication we’ve checked against Caprylic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
262Moderate
0Minor
2,567No known interaction
262 Moderate 2,567 No interaction
Moderate

262 interactions

Showing 60 of 262 moderate interactions — see all 262 on the Caprylic Acid page.

No interaction 2,567 drugs checked — show the list

We also checked Caprylic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,567 medications checked with no known interaction — see the full Caprylic Acid list.

See the full Caprylic Acid interactions page
See every supplement checked against Tafenoquine, ranked by severity
Evidence & sources

Caprylic Acid References

The 5 references that drive our Caprylic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Massolini G, Aubry AF, McGann A, Wainer IW. Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. Biochem Pharmacol 1993 PubMed
  2. Kristev A, Mitkov D, Lukanov Y, Chapkynov P. The effect of octanoic fatty acid on the cardiovascular system of the guinea pig. Cor Vasa 1989;31(4):321-7.
  3. Hayball PF, Holman JW, Nation RL. Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. J Chromatogr B Biomed App PubMed
  4. Noctor TA, Wainer IW, Hage DS. Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. J Chromatogr 1992;5 PubMed
  5. Voller B, Lines E, McCrossin G, et al. Dose-escalation study of octanoic acid in patients with essential tremor. J Clin Invest. 2016;126(4):1451-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Caprylic Acid and Tafenoquine Together: Common Questions

Is it safe to take Caprylic Acid with Tafenoquine?
We do not list a known interaction between Caprylic Acid and Tafenoquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Caprylic Acid and Tafenoquine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Caprylic Acid and Tafenoquine at the same time of day?
At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Caprylic Acid on an empty stomach out of habit, keep them separate and take Tafenoquine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tafenoquine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Caprylic Acid and Tafenoquine combination checked?
Interactions in our licensed database are recorded against drug classes. Tafenoquine is filed under 1 classification, and Caprylic Acid has documented interactions with 3 drug classes — none of Tafenoquine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Caprylic Acid interact with any other medications?
Yes. Caprylic Acid has 262 documented drug interactions in our database — Tafenoquine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tafenoquine interact with any supplements?
Yes. Tafenoquine has documented interactions with 17 supplements in our database — Caprylic Acid is not one of them. The Tafenoquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Caprylic Acid monograph Uses, safety profile, and every drug interaction in one place Tafenoquine drug information The full plain-English guide to this medication Tafenoquine supplement interactions Every supplement checked against Tafenoquine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tafenoquine and Caprylic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.