Drug & supplement interaction

Celery + Aspirin, Diphenhydramine, Phenylpropanolamine

Aspirin, Diphenhydramine, Phenylpropanolamine brand name: Alka Seltzer Plus Night Time Effervescent.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aspirin, Diphenhydramine, Phenylpropanolamine falls into 2 drug categories that Celery can interact with; the most serious is rated moderate. Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Celery and Aspirin, Diphenhydramine, Phenylpropanolamine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Celery interacts with whole categories of medication. Aspirin, Diphenhydramine, Phenylpropanolamine falls into 2 of those categories, so it can interact with Celery in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Aspirin, Diphenhydramine, Phenylpropanolamine

Aspirin, Diphenhydramine, Phenylpropanolamine falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Celery interacts with.

Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Celery root contains the constituents falcarinol and falcarindiol. Laboratory research suggests that these constituents can inhibit platelet aggregation. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product contains aspirin, which already thins the blood a bit by keeping platelets from clumping together. Celery seed or root supplements contain plant compounds (falcarinol and falcarindiol) that, in lab studies, seem to do something similar. Stack those two together and, in theory, you could nudge your bleeding risk a little higher. That might show up as easier bruising, nosebleeds, or bleeding that takes longer to stop.

Here's the honest part: this is based only on test-tube research, and it hasn't actually been seen in people. Eating celery as a normal food is very unlikely to matter. Concentrated celery supplements are where I'd be a bit more cautious. If you take those regularly, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  2. Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. J Pharm.Biomed.Anal. 6-7-2006;41(3):683-693. PubMed
Minor

PHOTOSENSITIZING DRUGS

2 of 2

Aspirin, Diphenhydramine, Phenylpropanolamine also falls under PHOTOSENSITIZING DRUGS.

Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Laboratory research shows that celery contains photosensitizing agents such as phenols and psoralens.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with this combo product (which mixes aspirin, the antihistamine diphenhydramine, and the decongestant phenylpropanolamine) and celery. Concentrated celery supplements contain natural compounds called psoralens that can make your skin more sensitive to sunlight. The thought is that pairing them might add to any sun sensitivity, leaving you a bit more prone to sunburn or a rash on exposed skin.

I'll be honest, this one is very theoretical and based on weak, anecdotal evidence. Eating celery as food is unlikely to cause any trouble. With celery supplements, just be a little extra mindful of sunscreen and covering up outdoors. If you have questions, your pharmacist is happy to help.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  2. Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
  3. Lombaert, G. A., Siemens, K. H., Pellaers, P., Mankotia, M., and Ng, W. Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. J AOAC Int 2001;84(4):1135-1143. DOI
  4. Gorgus, E., Lohr, C., Raquet, N., Guth, S., and Schrenk, D. Limettin and furocoumarins in beverages containing citrus juices or extracts. Food Chem.Toxicol. 2010;48(1):93-98. PubMed
  5. Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Food Chem.Toxicol. 1983;21(2):163-165. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Celery Also Interacts With Other Medications

Celery has 448 moderate, 202 minor known drug interactions in our database — the Aspirin, Diphenhydramine, Phenylpropanolamine one above is among them. If you take anything else, check it against the full list below.

Moderate 448 Minor 202 No known interaction 2,180 (incl. Aspirin, Diphenhydramine, Phenylpropanolamine)
Taking anything else?

Check Another of Your Medications Against Celery

Covers the 2,830 medications we’ve checked against Celery. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Diphenhydramine, Phenylpropanolamine

This page covers Celery only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Diphenhydramine, Phenylpropanolamine page lists 361 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 17 major · 308 moderate · 36 minor.

From our pharmacist’s overview on the Aspirin, Diphenhydramine, Phenylpropanolamine page

“A cold remedy used for a few nights can still collide with supplements taken daily, and Alka Seltzer Plus Night Time (aspirin, diphenhydramine, phenylpropanolamine) is one to treat with genuine care. Its three ingredients thin the blood, sedate, and stimulate all at once, which is why 361 supplements and herbs are on file here.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Diphenhydramine, Phenylpropanolamine interaction page

One more smart check

Taking Celery as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,687 real supplement products containing Celery, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Celery. Your product may carry other ingredients that interact with Aspirin, Diphenhydramine, Phenylpropanolamine too, on top of Celery — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Celery and Aspirin, Diphenhydramine, Phenylpropanolamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Celery
Top 25%

#161 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Diphenhydramine, Phenylpropanolamine
Steady interest

#1,536 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Celery

What is Celery?

Celery
  • High blood pressure
  • Fluid retention (diuretic)
  • Joint pain and inflammation
  • Anxiety and sleep
  • Digestive support

Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort. Human evidence for these supplement uses is limited and mostly preliminary, so it should not replace proven treatments. Celery is generally safe as food, but concentrated supplements and possible allergic reactions warrant caution.

Read the full Celery monograph & all interactions
Keep checking

Other Drugs & Celery

Browse every other medication we’ve checked against Celery — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
448Moderate
202Minor
2,179No known interaction
448 Moderate 202 Minor 2,179 No interaction
Moderate

448 interactions

Showing 60 of 448 moderate interactions — see all 448 on the Celery page.

Minor

202 interactions

Showing 60 of 202 minor interactions — see all 202 on the Celery page.

No interaction 2,179 drugs checked — show the list

We also checked Celery against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,179 medications checked with no known interaction — see the full Celery list.

See the full Celery interactions page
See every supplement checked against Aspirin, Diphenhydramine, Phenylpropanolamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Celery monograph › Uses, safety, and every drug interaction in one place Aspirin, Diphenhydramine, Phenylpropanolamine supplement interactions › Every supplement checked against Aspirin, Diphenhydramine, Phenylpropanolamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Celery and Aspirin, Diphenhydramine, Phenylpropanolamine Together: Common Questions

Can you take Celery with Aspirin, Diphenhydramine, Phenylpropanolamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Celery and Aspirin, Diphenhydramine, Phenylpropanolamine?
Aspirin, Diphenhydramine, Phenylpropanolamine belongs to more than one drug category, and Celery interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Celery and Aspirin, Diphenhydramine, Phenylpropanolamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Diphenhydramine, Phenylpropanolamine and Celery?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.