Medication interaction hub

What Supplements Interact with Aspirin, Diphenhydramine, Phenylpropanolamine?

Aspirin, Diphenhydramine, Phenylpropanolamine brand name: Alka Seltzer Plus Night Time Effervescent. Every interaction below applies to the brands too.

361 Interactions 17 Major 308 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Diphenhydramine, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Diphenhydramine, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A cold remedy used for a few nights can still collide with supplements taken daily, and Alka Seltzer Plus Night Time (aspirin, diphenhydramine, phenylpropanolamine) is one to treat with genuine care. Its three ingredients thin the blood, sedate, and stimulate all at once, which is why 361 supplements and herbs are on file here. The largest share, 202 of them, can add to aspirin's bleeding risk, while dozens more deepen the antihistamine's drowsiness or push the decongestant's effect on blood pressure higher.

Seventeen entries are rated major, and those deserve first attention. Ordinary alcohol is among them; beer or wine on top of diphenhydramine is a well-documented route to dangerous sedation, and kava deepens it the same way. Ephedra stacks a second stimulant onto phenylpropanolamine. The other 308 moderate and 36 minor entries mostly echo these themes at lower intensity, worth a look once the majors are handled.

— , Clinical Pharmacist · July 18, 2026

Major 17 Moderate 308 Minor 36 No known interaction 1,091

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Diphenhydramine, Phenylpropanolamine: Top Interactions at a Glance

The Aspirin, Diphenhydramine, Phenylpropanolamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 361 interacting ingredients — plus 1,091 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Diphenhydramine, Phenylpropanolamine Combinations Today

The Aspirin, Diphenhydramine, Phenylpropanolamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Aspirin, Diphenhydramine, Phenylpropanolaminei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Moderate Likelihood Possible Black Pepper + Aspirin, Diphenhydramine, Phenylpropanolaminei

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.

Read the full interaction Moderate Likelihood Possible Carrageenan + Aspirin, Diphenhydramine, Phenylpropanolaminei

Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Borage + Aspirin, Diphenhydramine, Phenylpropanolaminei

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Wasabi + Aspirin, Diphenhydramine, Phenylpropanolaminei

Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Likely Beer + Aspirin, Diphenhydramine, Phenylpropanolaminei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Diphenhydramine, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 361 with a Aspirin, Diphenhydramine, Phenylpropanolamine interaction on file and 1,091 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Diphenhydramine, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Gamma-hydroxybutyrate (ghb) with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Black Pepper with Aspirin, Diphenhydramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.

Full Black Pepper + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Carrageenan with Aspirin, Diphenhydramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Full Carrageenan + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Borage with Aspirin, Diphenhydramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Wasabi with Aspirin, Diphenhydramine, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Wasabi + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Umckaloabo with Aspirin, Diphenhydramine, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Pelargonium sidoides might increase the risk of bleeding when taken with anticoagulant and antiplatelet drugs.

Full Umckaloabo + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Beer with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Siberian Cocklebur with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Wine with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take 1,4-butanediol with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Activated Charcoal with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Danshen with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Ephedra with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Ephedra + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Henbane with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Kava with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take L-tryptophan with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Peyote with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Piracetam with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Piracetam + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Rauvolfia Vomitoria with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Aspirin, Diphenhydramine, Phenylpropanolamine answer

Can you take Scopolia with Aspirin, Diphenhydramine, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of...

Full Scopolia + Aspirin, Diphenhydramine, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Diphenhydramine, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Diphenhydramine, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Diphenhydramine, Phenylpropanolamine sits in 15 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Aspirin, Diphenhydramine, Phenylpropanolamine through this category.

Related: does Aspirin, Diphenhydramine, Phenylpropanolamine deplete any nutrients?

Aspirin, Diphenhydramine, Phenylpropanolamine has 4 reported nutrient associations in the research literature — see the Aspirin, Diphenhydramine, Phenylpropanolamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Diphenhydramine, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Diphenhydramine, Phenylpropanolamine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Aspirin, Diphenhydramine, Phenylpropanolamine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Aspirin, Diphenhydramine, Phenylpropanolamine.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Aspirin, Diphenhydramine, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Aspirin, Diphenhydramine, Phenylpropanolamine?
Our database currently documents 361 ingredients with a known Aspirin, Diphenhydramine, Phenylpropanolamine interaction (17 major, 308 moderate, 36 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 361. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Aspirin, Diphenhydramine, Phenylpropanolamine supplement interactions are the most serious?
The 17 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Diphenhydramine, Phenylpropanolamine?
Plenty of supplements coexist fine with Aspirin, Diphenhydramine, Phenylpropanolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Alka Seltzer Plus Night Time Effervescent have the same supplement interactions as Aspirin, Diphenhydramine, Phenylpropanolamine?
Yes — Alka Seltzer Plus Night Time Effervescent all contain Aspirin, Diphenhydramine, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Diphenhydramine, Phenylpropanolamine deplete any vitamins or nutrients?
It might — Aspirin, Diphenhydramine, Phenylpropanolamine has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Diphenhydramine, Phenylpropanolamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Diphenhydramine, Phenylpropanolamine and my other medications?
This page covers Aspirin, Diphenhydramine, Phenylpropanolamine against supplements and herbal ingredients. Checking Aspirin, Diphenhydramine, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.