Drug & supplement interaction

Ceylon Cinnamon + Doxazosin Mesylate

Doxazosin Mesylate brand name: Cardura.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ceylon Cinnamon has a moderate interaction with Doxazosin Mesylate. Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Ceylon Cinnamon and Doxazosin Mesylate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Doxazosin Mesylate

Doxazosin Mesylate falls under ANTIHYPERTENSIVE DRUGS — the group Ceylon Cinnamon interacts with.

Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: doxazosin already lowers your blood pressure by relaxing blood vessels. Ceylon cinnamon, in concentrated supplement form, may have a mild blood-pressure-lowering effect of its own. Put the two together and they could add up, nudging your pressure a little lower than expected. In real life that might show up as dizziness, lightheadedness when you stand up, or feeling tired or faint, which is something doxazosin can already cause (especially with the first dose or after a dose increase).

How worried should you be? Not very. This concern comes only from lab and animal studies, so it's theoretical. The cinnamon you sprinkle on food is unlikely to matter. If you want to take cinnamon capsules regularly, check with your pharmacist or doctor first, and tell them if you notice new dizziness.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
  2. Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ceylon Cinnamon Also Interacts With Other Medications

Ceylon Cinnamon has 257 moderate known drug interactions in our database — the Doxazosin Mesylate one above is one of them. If you take anything else, check it against the full list below.

Moderate 257 No known interaction 2,573 (incl. Doxazosin Mesylate)
Taking anything else?

Check Another of Your Medications Against Ceylon Cinnamon

Covers the 2,830 medications we’ve checked against Ceylon Cinnamon. Pick one to open its full report.

From our Q&A

Questions About Ceylon Cinnamon or Doxazosin Mesylate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ceylon Cinnamon or Doxazosin Mesylate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Doxazosin Mesylate

This page covers Ceylon Cinnamon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxazosin Mesylate page lists 137 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 112 moderate · 21 minor.

From our pharmacist’s overview on the Doxazosin Mesylate page

“Doxazosin (Cardura) relaxes blood vessels to lower blood pressure and ease enlarged-prostate symptoms, and it already has a reputation for dizziness and first-dose fainting. That is why its list of 137 interacting supplements deserves genuine respect.”

Reviewed by 2 · Jul 18, 2026

Open the Doxazosin Mesylate interaction page

One more smart check

Taking Ceylon Cinnamon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 362 real supplement products containing Ceylon Cinnamon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Cinnamon. Your product may carry other ingredients that interact with Doxazosin Mesylate too, on top of Ceylon Cinnamon — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ceylon Cinnamon and Doxazosin Mesylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ceylon Cinnamon
Top 25%

#338 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxazosin Mesylate
Top half

#931 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ceylon Cinnamon

What is Ceylon Cinnamon?

Ceylon Cinnamon
  • Blood sugar support
  • High cholesterol
  • Indigestion and gas
  • Antimicrobial
  • General flavoring and culinary use

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited and mixed, but as a food it is generally safe and contains far less coumarin than common cassia cinnamon. Talk with your pharmacist or doctor before taking concentrated supplements, especially if you have a health condition or take medications.

Read the full Ceylon Cinnamon monograph & all interactions
Medication

About Doxazosin

What Is Doxazosin Used For?

Brand name: Cardura

Doxazosin tablets — sold as Cardura, Doxazosin, and Doxazosin mesylate — treat two conditions: the urinary symptoms of benign prostatic hyperplasia (BPH, an enlarged prostate) and high blood pressure (hypertension). For hypertension, lowering blood pressure reduces the risk of serious events like stroke and heart attack.

Cardura XL (extended-release tablet) is approved only for BPH symptoms. It is not approved for the treatment of hypertension.

See full Doxazosin drug information
Keep checking

Other Drugs & Ceylon Cinnamon

Browse every other medication we’ve checked against Ceylon Cinnamon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
257Moderate
0Minor
2,572No known interaction
257 Moderate 2,572 No interaction
Moderate

257 interactions

Showing 60 of 257 moderate interactions — see all 257 on the Ceylon Cinnamon page.

No interaction 2,572 drugs checked — show the list

We also checked Ceylon Cinnamon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,572 medications checked with no known interaction — see the full Ceylon Cinnamon list.

See the full Ceylon Cinnamon interactions page
See every supplement checked against Doxazosin Mesylate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ceylon Cinnamon monograph › Uses, safety, and every drug interaction in one place Doxazosin Mesylate supplement interactions › Every supplement checked against Doxazosin Mesylate, ranked by severity Doxazosin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ceylon Cinnamon and Doxazosin Mesylate Together: Common Questions

Can you take Ceylon Cinnamon with Doxazosin Mesylate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ceylon Cinnamon and Doxazosin Mesylate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Doxazosin Mesylate and Ceylon Cinnamon?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.