Drug & supplement interaction

Chive + Methazolamide

Methazolamide brand name: Neptazane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chive and Methazolamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chive and Methazolamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methazolamide and Chive in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chive at all — not against Methazolamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chive safety at a glance

Chive overall Generally safe Chive is generally safe when eaten in normal food amounts.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplement doses since they are not well studied.
Breastfeeding Use caution Normal culinary amounts are likely fine; concentrated supplements lack safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methazolamide and Chive? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chive and Methazolamide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Chive

    “Orally, chive is generally well tolerated. Consuming large quantities of chive can lead to dyspepsia (18).

    Topically, chive has been rarely reported to cause contact dermatitis.”

    Chive · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 4912. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 41757. Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375.

    “Orally, large, unspecified quantities of chive can cause dyspepsia (18).”

    Chive · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Methazolamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Methazolamide. Read the label on DailyMed ›

Reported for Chive but not commonly for Methazolamide: a skin rash.

Effects for Methazolamide come from the ADVERSE REACTIONS section of its FDA label; effects for Chive come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 339 voluntary FDA FAERS reports for Methazolamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Methazolamide

This page covers Chive only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methazolamide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Methazolamide page

“Methazolamide (Neptazane) treats glaucoma by lowering pressure inside the eye, and because it also has mild water-pill effects it can nudge blood pressure and potassium on its own. That is exactly where most of the 218 supplements on this page press, and the list earns real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Methazolamide interaction page

One more smart check

Taking Chive as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing Chive, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chive. Even though Chive itself has no known interaction with Methazolamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chive and Methazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chive
Steady interest

#951 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methazolamide
Steady interest

#1,739 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chive reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chive and Methazolamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chive

What is Chive?

  • Culinary flavoring
  • Digestive support
  • General immune support
  • Antimicrobial
  • Source of vitamins and antioxidants

Chive is a common kitchen herb in the onion and garlic family that is safe and nutritious when eaten as food. There is little human research supporting it as a medicine, so any health benefits beyond basic nutrition are not well proven. Enjoy it in cooking, and talk to your pharmacist or doctor before using concentrated chive supplements.

Allium schoenoprasum · Amaryllidaceae · Leaves (and sometimes flowers and bulbs) · Fresh or dried herb, culinary seasoning, powder, occasional supplement extracts

An interaction check asks whether these two react with each other — it does not ask whether Chive is a good idea for someone in your situation. Here is what our Chive record says about it on its own.

Chive: dosing

There is no established medicinal dose for chive. It is normally used in whatever amount tastes good in food.

From our Chive monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chive monograph & all interactions
Medication

About Methazolamide

What Is Methazolamide Used For?

Brand name: Neptazane

Methazolamide tablets are used to treat eye conditions where lowering intraocular pressure (pressure inside the eye) is expected to help. These include chronic open-angle glaucoma and secondary glaucoma.

Methazolamide tablets are also used before surgery in acute angle-closure glaucoma, when reducing eye pressure ahead of the procedure is needed. Note that long-term use in angle-closure glaucoma is not appropriate.

Most-Reported Side Effects for Methazolamide

From FAERS, the FDA’s public side-effect reporting system (339 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 41 reports
Dizziness 29 reports
Dyspnea 28 reports
Headache 28 reports
Blood pressure increased 22 reports
See full Methazolamide drug information
Keep checking

Other Drugs & Chive

Browse every other medication we’ve checked against Chive — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chive against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chive list.

See the full Chive interactions page
See every supplement checked against Methazolamide, ranked by severity
Evidence & sources

Chive References

The 3 references that drive our Chive monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chive and Methazolamide Together: Common Questions

Is it safe to take Chive with Methazolamide?
We do not list a known interaction between Chive and Methazolamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chive and Methazolamide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Methazolamide interact with any supplements?
Yes. Methazolamide has documented interactions with 218 supplements in our database — Chive is not one of them. The Methazolamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chive monograph Uses, safety profile, and every drug interaction in one place Methazolamide drug information The full plain-English guide to this medication Methazolamide supplement interactions Every supplement checked against Methazolamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methazolamide and Chive?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.