Drug & supplement interaction

Coconut + Mifepristone

Mifepristone brand names: Mifeprex, Korlym.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Coconut and Mifepristone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Coconut and Mifepristone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mifepristone and Coconut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coconut safety at a glance

Coconut overall Generally safe Coconut is generally safe when eaten in normal food amounts.
Pregnancy Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnan... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnan... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mifepristone and Coconut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mifepristone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mifepristone is filed under 4 classifications — including qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates. Coconut has documented interactions with 1 drug class — the most serious being antidiabetes drugs (minor) — and none of Mifepristone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coconut Does Interact With Other Medications

Coconut has 86 minor known drug interactions in our database — Mifepristone isn’t one of them. If you take anything else, check it against the full list below.

Minor 86 No known interaction 2,744 (incl. Mifepristone)
Taking anything else?

Check Another of Your Medications Against Coconut

Covers the 2,830 medications we’ve checked against Coconut. Pick one to open its full report.

What to actually watch for

What Coconut Itself Has Been Linked To

This is not an interaction — nothing below involves Mifepristone. It is the side-effect record for Coconut on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Coconut, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Wheezing / Shortness of breath Worth acting on Additional detail

    “Although coconut is a stone fruit, in the US, coconut is grouped with tree nuts for allergen declaration purposes. Orally or topically, coconut can cause allergic reactions ranging from hives to anaphylaxis in those with hypersensitivity to coconut or its pollen.”

    Coconut · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 107673. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
    2. 12359. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
    3. 26561. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
    4. 95806. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
    5. 95807. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
    6. 95808. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  • A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Orally, coconut is generally well tolerated.

    Most Common Adverse Effects:

    Orally and topically: Allergic reactions, including anaphylaxis and hives.”

    Coconut · Natural Medicines adverse-effect record, reported in urticaria.

  • A stuffy or runny nose / Swelling / Vomiting Additional detail

    Recorded for Coconut in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath above.

Everything above comes from the Natural Medicines adverse-effect record for Coconut — expand a row for the licensed statement it rests on. We haven’t matched Mifepristone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Mifepristone.

Special populations

Coconut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnancy and lactation; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Mifepristone Is Prescribed For, and What Coconut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mifepristone is a prescription medicine with approved uses on its FDA label. Coconut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Mifepristone is prescribed for: Korlym is prescribed for adults with endogenous Cushing's syndrome — a condition where the body produces too much cortisol — who also have type 2 diabetes or trouble controlling blood sugar. It works to bring those blood sugar levels under control. It is only for blood sugar problems that are directly caused by Cushing's syndrome. It should not be used to treat ordinary type 2 diabetes unrelated to this condition.

Coconut has been studied for:

  • Diabetes studied, not established Coconut has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Coconut for diabetes

    Although there is interest in using oral coconut for diabetes, there is insufficient reliable information about the clinical effects of coconut for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mifepristone on your own; if you are taking Coconut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Coconut or Mifepristone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coconut or Mifepristone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mifepristone

This page covers Coconut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mifepristone page lists 151 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 104 moderate · 39 minor.

From our pharmacist’s overview on the Mifepristone page

“Mifepristone is a drug where a failed dose has real consequences, whether it is Mifeprex used to end an early pregnancy or Korlym taken daily for Cushing's syndrome, so its interaction list deserves genuine respect. Most of the 151 ingredients on file act on the CYP3A4 enzyme that clears the drug, pushing its blood level up or dragging…”

Reviewed by 2 · Jul 18, 2026

Open the Mifepristone interaction page

One more smart check

Taking Coconut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 806 real supplement products containing Coconut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut. Even though Coconut itself has no known interaction with Mifepristone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut and Mifepristone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut
Top 25%

#180 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mifepristone
Top 25%

#684 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coconut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Coconut and Mifepristone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coconut

What is Coconut?

  • Skin and hair care
  • Source of dietary fats (MCTs)
  • Hydration with coconut water
  • Cooking and weight management
  • Antimicrobial (traditional use)

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) have reasonable support, many health claims for coconut oil are weak or unproven, and coconut oil is high in saturated fat. Talk with your pharmacist or doctor before using coconut products in large or medicinal amounts.

Cocos nucifera · Arecaceae · Fruit (flesh and water), oil, and milk · Coconut oil, coconut water, coconut milk, dried/shredded flesh, capsules (MCT oil)

An interaction check asks whether these two react with each other — it does not ask whether Coconut is a good idea for someone in your situation. Here is what our Coconut record says about it on its own.

Coconut: dosing

There is no standardized medicinal dose for coconut products. As a food, coconut oil, water, milk, and flesh are used in everyday cooking and drinking amounts.If you use a coconut or MCT oil supplement, follow the directions on the product label.

From our Coconut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coconut monograph & all interactions
Medication

About Mifepristone (Korlym)

What Is Mifepristone (Korlym) Used For?

Brand names: Mifeprex, Korlym

Korlym is prescribed for adults with endogenous Cushing's syndrome — a condition where the body produces too much cortisol — who also have type 2 diabetes or trouble controlling blood sugar. It works to bring those blood sugar levels under control.

It is only for blood sugar problems that are directly caused by Cushing's syndrome. It should not be used to treat ordinary type 2 diabetes unrelated to this condition.

Most-Reported Side Effects for Mifepristone

From FAERS, the FDA’s public side-effect reporting system (4,696 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 794 reports
Fatigue 695 reports
Blood potassium decreased 453 reports
Vomiting 435 reports
Dizziness 401 reports
See full Mifepristone (Korlym) drug information
Keep checking

Other Drugs & Coconut

Browse every other medication we’ve checked against Coconut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
86Minor
2,743No known interaction
86 Minor 2,743 No interaction
Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Coconut page.

No interaction 2,743 drugs checked — show the list

We also checked Coconut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Coconut list.

See the full Coconut interactions page
See every supplement checked against Mifepristone, ranked by severity
Evidence & sources

Coconut References

The 10 references that drive our Coconut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coconut and Mifepristone Together: Common Questions

Is it safe to take Coconut with Mifepristone?
We do not list a known interaction between Coconut and Mifepristone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Coconut and Mifepristone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coconut in each. That is a conversation for your prescriber, especially if Mifepristone is being adjusted to a target.
How was the Coconut and Mifepristone combination checked?
Interactions in our licensed database are recorded against drug classes. Mifepristone is filed under 4 classifications, and Coconut has documented interactions with 1 drug class — none of Mifepristone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coconut interact with any other medications?
Yes. Coconut has 86 documented drug interactions in our database — Mifepristone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mifepristone interact with any supplements?
Yes. Mifepristone has documented interactions with 151 supplements in our database — Coconut is not one of them. The Mifepristone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coconut monograph Uses, safety profile, and every drug interaction in one place Mifepristone (Korlym) drug information The full plain-English guide to this medication Mifepristone supplement interactions Every supplement checked against Mifepristone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mifepristone and Coconut?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.