Drug & supplement interaction

Cordyceps + Trilaciclib Dihydrochloride

Trilaciclib Dihydrochloride brand name: Cosela.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 27, 2026

The bottom line No known interaction

We found no known interaction between Cordyceps and Trilaciclib Dihydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cordyceps and Trilaciclib Dihydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trilaciclib Dihydrochloride and Cordyceps in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cordyceps safety at a glance

Cordyceps overall Use caution Generally well tolerated short-term, but evidence is limited and product quality varies widely.

Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.

Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trilaciclib Dihydrochloride and Cordyceps? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Trilaciclib Dihydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trilaciclib Dihydrochloride is filed under a single classification — qt interval-prolonging drugs. Cordyceps has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), immunosuppressants (moderate) and testosterone (minor) — and none of Trilaciclib Dihydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cordyceps Does Interact With Other Medications

Cordyceps has 241 moderate, 8 minor known drug interactions in our database — Trilaciclib Dihydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 241 Minor 8 No known interaction 2,581 (incl. Trilaciclib Dihydrochloride)

Taking anything else?

Check Another of Your Medications Against Cordyceps

Covers the 2,830 medications we’ve checked against Cordyceps. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cordyceps and Trilaciclib Dihydrochloride May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Liver problems Worth acting on Additional detail
Cordyceps
“There is a case report of acute cholestatic hepatitis probably associated with the use of a product containing cordyceps. The 64-year-old male was asymptomatic except for jaundice and laboratory markers and recovered once the supplement was stopped. However, it is unclear whether the hepatitis is associated with the cordyceps or with an unknown contaminant.”

Cordyceps · Natural Medicines adverse-effect record, reported in hepatitis.
1 source cited

109704. Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
Trilaciclib Dihydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Trilaciclib Dihydrochloride. Read the label on DailyMed ›

Reported for Cordyceps but not commonly for Trilaciclib Dihydrochloride: stomach upset, reduced appetite, constipation and dry mouth.

Effects for Trilaciclib Dihydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Cordyceps come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Trilaciclib Dihydrochloride Is Prescribed For, and What Cordyceps Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Trilaciclib Dihydrochloride is a prescription medicine with approved uses on its FDA label. Cordyceps is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Trilaciclib Dihydrochloride is prescribed for: Cosela (trilaciclib) is given to adults with extensive-stage small cell lung cancer (ES-SCLC) to decrease chemotherapy-induced myelosuppression — meaning it helps protect the bone marrow from the blood-cell-lowering effects of certain chemotherapy regimens. Cosela is approved for use before platinum/etoposide-containing chemotherapy regimens or topotecan-containing regimens in ES-SCLC. It is given as an intravenous infusion before chemotherapy on each day that chemotherapy is administered.

Cordyceps has been studied for:

Lung cancer studied, not established Cordyceps has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Cordyceps for lung cancer

It is unclear if oral cordyceps is beneficial in patients with lung cancer on chemotherapy or radiotherapy.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Trilaciclib Dihydrochloride on your own; if you are taking Cordyceps for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Trilaciclib Dihydrochloride

This page covers Cordyceps only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trilaciclib Dihydrochloride page lists 13 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 6 major · 7 moderate.

From our pharmacist’s overview on the Trilaciclib Dihydrochloride page

“Trilaciclib (Cosela) is an infusion given before chemotherapy to shield bone marrow in people with small cell lung cancer, and its supplement list deserves genuine attention because all 13 flagged ingredients press on the same weak point, the heart's electrical rhythm. Each can lengthen the QT interval, the pause between beats on an EC…”

Reviewed by 2 · Jul 18, 2026

Open the Trilaciclib Dihydrochloride interaction page

One more smart check

Taking Cordyceps as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,140 real supplement products containing Cordyceps, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cordyceps. Even though Cordyceps itself has no known interaction with Trilaciclib Dihydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cordyceps and Trilaciclib Dihydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cordyceps

Top 10%

#121 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Trilaciclib Dihydrochloride

Steady interest

#2,439 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cordyceps reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Cordyceps and Trilaciclib Dihydrochloride records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cordyceps

What is Cordyceps?

Fatigue and low energy
Athletic performance and stamina
Respiratory and lung support
Immune support
Kidney health support
General wellness/anti-aging

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits are not well proven. It appears generally well tolerated in the short term, but quality varies and it should be avoided in pregnancy and breastfeeding due to lack of safety data.

Ophiocordyceps sinensis · Ophiocordycipitaceae · Whole fungus (fruiting body and mycelium), often grown in culture as the Cs-4 strain · Capsules, tablets, powders, extracts, teas, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Cordyceps is a good idea for someone in your situation. Here is what our Cordyceps record says about it on its own.

Cordyceps: dosing

There is no official or standardized dose for cordyceps. Doses used in studies have varied widely depending on the product, species, and extract type.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Cordyceps monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cordyceps monograph & all interactions

Medication

About Trilaciclib Injection

What Is Trilaciclib Injection Used For?

Brand name: Cosela

Cosela (trilaciclib) is given to adults with extensive-stage small cell lung cancer (ES-SCLC) to decrease chemotherapy-induced myelosuppression — meaning it helps protect the bone marrow from the blood-cell-lowering effects of certain chemotherapy regimens.

Cosela is approved for use before platinum/etoposide-containing chemotherapy regimens or topotecan-containing regimens in ES-SCLC. It is given as an intravenous infusion before chemotherapy on each day that chemotherapy is administered.

See full Trilaciclib Injection drug information

Keep checking

Other Drugs & Cordyceps

Browse every other medication we’ve checked against Cordyceps — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

241Moderate

8Minor

2,580No known interaction

241 Moderate 8 Minor 2,580 No interaction

Moderate

241 interactions

Showing 60 of 241 moderate interactions — see all 241 on the Cordyceps page.

Minor

8 interactions

No interaction 2,580 drugs checked — show the list

We also checked Cordyceps against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,580 medications checked with no known interaction — see the full Cordyceps list.

See the full Cordyceps interactions page

See every supplement checked against Trilaciclib Dihydrochloride, ranked by severity

Evidence & sources

Cordyceps References

The 14 references that drive our Cordyceps monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cordyceps and Trilaciclib Dihydrochloride Together: Common Questions

Is it safe to take Cordyceps with Trilaciclib Dihydrochloride?

We do not list a known interaction between Cordyceps and Trilaciclib Dihydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Cordyceps and Trilaciclib Dihydrochloride have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Cordyceps and Trilaciclib Dihydrochloride used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Cordyceps in each. That is a conversation for your prescriber, especially if Trilaciclib Dihydrochloride is being adjusted to a target.

How was the Cordyceps and Trilaciclib Dihydrochloride combination checked?

Interactions in our licensed database are recorded against drug classes. Trilaciclib Dihydrochloride is filed under 1 classification, and Cordyceps has documented interactions with 3 drug classes — none of Trilaciclib Dihydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cordyceps interact with any other medications?

Yes. Cordyceps has 249 documented drug interactions in our database — Trilaciclib Dihydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Trilaciclib Dihydrochloride interact with any supplements?

Yes. Trilaciclib Dihydrochloride has documented interactions with 13 supplements in our database — Cordyceps is not one of them. The Trilaciclib Dihydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cordyceps monograph Uses, safety profile, and every drug interaction in one place Trilaciclib Injection drug information The full plain-English guide to this medication Trilaciclib Dihydrochloride supplement interactions Every supplement checked against Trilaciclib Dihydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trilaciclib Dihydrochloride and Cordyceps?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.