Drug & supplement interaction

Cordyceps + Bromfenac Sodium

Bromfenac Sodium brand names: Prolensa, Bromsite.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cordyceps has a moderate interaction with Bromfenac Sodium. Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Cordyceps and Bromfenac Sodium

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Bromfenac Sodium

Bromfenac Sodium falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Cordyceps interacts with.

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news first: bromfenac (Prolensa, BromSite) is an eye drop you put right on the surface of the eye after cataract surgery. Very little of it gets into your bloodstream, so a whole-body bleeding interaction with cordyceps is much less of a concern than it would be with a pill.

The theory on file is that cordyceps might make platelets a little 'slipperier,' which could in theory add to the mild blood-thinning effect that NSAIDs like bromfenac can have. But this is based only on lab and animal studies, not on people, so I'd call it more of a 'good to know' than a real worry. If you notice unusual eye redness, bleeding, or slow healing after surgery, mention it to your eye doctor or pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  2. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cordyceps Also Interacts With Other Medications

Cordyceps has 240 moderate, 8 minor known drug interactions in our database — the Bromfenac Sodium one above is one of them. If you take anything else, check it against the full list below.

Moderate 240 Minor 8 No known interaction 2,582 (incl. Bromfenac Sodium)
Taking anything else?

Check Another of Your Medications Against Cordyceps

Covers the 2,830 medications we’ve checked against Cordyceps. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Bromfenac Sodium

This page covers Cordyceps only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bromfenac Sodium page lists 209 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Danshen (major), Piracetam (major), Wine (major) and Aconite (moderate).

By severity: 4 major · 186 moderate · 19 minor.

From our pharmacist’s overview on the Bromfenac Sodium page

“The typical person using bromfenac sodium drops (Prolensa, Bromsite) has just had cataract surgery, often older and often a daily supplement taker, a combination that deserves genuine care. Bromfenac is an NSAID, and 202 of the 209 ingredients here have blood-thinning or antiplatelet activity that can stack with it and make bleeding ea…”

Reviewed by 2 · Jul 18, 2026

Open the Bromfenac Sodium interaction page

One more smart check

Taking Cordyceps as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,140 real supplement products containing Cordyceps, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cordyceps. Your product may carry other ingredients that interact with Bromfenac Sodium too, on top of Cordyceps — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cordyceps and Bromfenac Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cordyceps
Top 10%

#122 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bromfenac Sodium
Steady interest

#1,568 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cordyceps

What is Cordyceps?

Cordyceps
  • Fatigue and low energy
  • Athletic performance and stamina
  • Respiratory and lung support
  • Immune support
  • Kidney health support
  • General wellness/anti-aging

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits are not well proven. It appears generally well tolerated in the short term, but quality varies and it should be avoided in pregnancy and breastfeeding due to lack of safety data.

Read the full Cordyceps monograph & all interactions
Medication

About Bromfenac Ophthalmic

What Is Bromfenac Ophthalmic Used For?

Brand names: Prolensa, Bromsite

Bromfenac ophthalmic solution is used to treat postoperative inflammation (swelling and irritation) and to reduce eye pain in patients who have had cataract surgery. It is applied directly to the eye as drops.

See full Bromfenac Ophthalmic drug information
Keep checking

Other Drugs & Cordyceps

Browse every other medication we’ve checked against Cordyceps — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
240Moderate
8Minor
2,581No known interaction
240 Moderate 8 Minor 2,581 No interaction
Moderate

240 interactions

Showing 60 of 240 moderate interactions — see all 240 on the Cordyceps page.

Minor

8 interactions

No interaction 2,581 drugs checked — show the list

We also checked Cordyceps against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Cordyceps list.

See the full Cordyceps interactions page
See every supplement checked against Bromfenac Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cordyceps monograph › Uses, safety, and every drug interaction in one place Bromfenac Sodium supplement interactions › Every supplement checked against Bromfenac Sodium, ranked by severity Bromfenac Ophthalmic drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cordyceps and Bromfenac Sodium Together: Common Questions

Can you take Cordyceps with Bromfenac Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cordyceps and Bromfenac Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bromfenac Sodium and Cordyceps?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.